当前位置： SCI文献检索 > HEART RHYTHM期刊下所有文献 > Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: Basis for atrial-selective block by ranolazine.

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: Basis for atrial-selective block by ranolazine.

Abstract：

BACKGROUND:Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The antianginal agent ranolazine is a prototypic atrial-selective voltage-gated Na+ channel blocker but the mechanisms underlying its atrial-selective action remain unclear. OBJECTIVE:The present study examined the mechanisms underlying the atrial-selective action of ranolazine. METHODS:Whole-cell voltage-gated Na+ currents (INa) were recorded at room temperature (∼22°C) from rabbit isolated left atrial and right ventricular myocytes. RESULTS:INa conductance density was ∼1.8-fold greater in atrial than in ventricular cells. Atrial INa was activated at command potentials ∼7 mV more negative and inactivated at conditioning potentials ∼11 mV more negative than ventricular INa. The onset of inactivation of INa was faster in atrial cells than in ventricular myocytes. Ranolazine (30 μM) inhibited INa in atrial and ventricular myocytes in a use-dependent manner consistent with preferential activated/inactivated state block. Ranolazine caused a significantly greater negative shift in voltage of half-maximal inactivation in atrial cells than in ventricular cells, the recovery from inactivation of INa was slowed by ranolazine to a greater extent in atrial myocytes than in ventricular cells, and ranolazine produced an instantaneous block that showed marked voltage dependence in atrial cells. CONCLUSION:Differences exist between rabbit atrial and ventricular myocytes in the biophysical properties of INa. The more negative voltage dependence of INa activation and inactivation, together with trapping of the drug in the inactivated channel, underlies an atrial-selective action of ranolazine.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Caves RE,Cheng H,Choisy SC,Gadeberg HC,Bryant SM,Hancox JC,James AF

doi

10.1016/j.hrthm.2017.06.012

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1657-1664

issue

11

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(17)30729-4

journal_volume

14

pub_type

杂志文章

相关文献

HEART RHYTHM文献大全
  • A clinical feasibility study of atrial and ventricular electromechanical wave imaging.

    abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) and atrial ablation procedures currently lack a noninvasive imaging modality for reliable treatment planning and monitoring. Electromechanical wave imaging (EWI) is an ultrasound-based method that has previously been shown to be capable of noninvasively and transmurall...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2013.02.028

    authors： Provost J,Gambhir A,Vest J,Garan H,Konofagou EE

    更新日期：2013-06-01 00:00:00

  • Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction.

    abstract：BACKGROUND:We previously showed that the cardioversion threshold (CVT) for ventricular tachycardia (VT) is phase dependent when a single monophasic shock (1MP) is used. OBJECTIVE:The purpose of this study was to extend these findings to a biphasic shock (1BP) and to compare the efficacy of phase-independent multiple m...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2009.03.015

    authors： Li W,Ripplinger CM,Lou Q,Efimov IR

    更新日期：2009-07-01 00:00:00

  • Differential diagnosis of regular, narrow-QRS tachycardias.

    abstract：:We present an update on clinical and electrophysiological criteria used for the differential diagnosis of regular supraventricular tachycardias. Although several electrocardiographic clues may assist in the differential diagnosis, this is usually accomplished at electrophysiology study, and most often, the differentia...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2015.03.046

    authors： Katritsis DG,Josephson ME

    更新日期：2015-07-01 00:00:00

  • Epicardial organization of human ventricular fibrillation.

    abstract：OBJECTIVE:The objective of this study was to test the hypothesis that on the epicardium of the in vivo human heart, ventricular fibrillation (VF) consists of chaotic small wavefronts that constantly change paths. BACKGROUND:Despite the significance of VF to cardiovascular mortality, little is known about the wavefront...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2004.01.007

    authors： Nanthakumar K,Walcott GP,Melnick S,Rogers JM,Kay MW,Smith WM,Ideker RE,Holman W

    更新日期：2004-05-01 00:00:00

  • Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal.

    abstract：BACKGROUND:The R582C mutation is one of many Long-QT Syndrome type 2 (LQT2)-causing mutations localized to the human ether-a-go-go related gene (hERG) channel's S5-P linker subdomain, yet its specific mechanism of dysfunction has not been examined. OBJECTIVE:This study sought to characterize the biophysical properties...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.02.035

    authors： Fougere RR,Es-Salah-Lamoureux Z,Rezazadeh S,Eldstrom J,Fedida D

    更新日期：2011-08-01 00:00:00

  • Effects of atrial fibrillation substrate and spatiotemporal organization on atrial defibrillation thresholds.

    abstract：BACKGROUND:We previously showed that canine models of atrial fibrillation (AF) have different substrates (either structural or electrical) that lead to differences in AF characteristics. OBJECTIVE:The purpose of this study was to determine whether the differences in AF characteristics also would lead to differences in...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2007.03.032

    authors： Everett TH 4th,Wilson EE,Olgin JE

    更新日期：2007-08-01 00:00:00

  • Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: a 2-center study.

    abstract：BACKGROUND:For late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) assessment of atrial scar to guide management and targeting of ablation in atrial fibrillation (AF), an objective, reproducible method of identifying atrial scar is required. OBJECTIVE:To describe an automated method for operator-...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2013.04.030

    authors： Malcolme-Lawes LC,Juli C,Karim R,Bai W,Quest R,Lim PB,Jamil-Copley S,Kojodjojo P,Ariff B,Davies DW,Rueckert D,Francis DP,Hunter R,Jones D,Boubertakh R,Petersen SE,Schilling R,Kanagaratnam P,Peters NS

    更新日期：2013-08-01 00:00:00

  • High-density epicardial mapping of the pulmonary vein-left atrial junction in humans: insights into mechanisms of pulmonary vein arrhythmogenesis.

    abstract：BACKGROUND:The pulmonary veins (PVs) and the PV-LA (left atrium) junction are established sources of triggers initiating atrial fibrillation. In addition, they have been implicated in the maintenance of arrhythmia. OBJECTIVE:To undertake high-density electrophysiological characterization of the right superior PV-LA ju...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.09.010

    authors： Lee G,Spence S,Teh A,Goldblatt J,Larobina M,Atkinson V,Brown R,Morton JB,Sanders P,Kistler PM,Kalman JM

    更新日期：2012-02-01 00:00:00

  • A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death.

    abstract：BACKGROUND:Both schizophrenia and epilepsy have been linked to increased risk of sudden cardiac death (SCD). We hypothesized that DNA variants within genes previously associated with schizophrenia and epilepsy may contribute to an increased risk of SCD. OBJECTIVE:To investigate the contribution to SCD susceptibility o...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2013.03.020

    authors： Huertas-Vazquez A,Teodorescu C,Reinier K,Uy-Evanado A,Chugh H,Jerger K,Ayala J,Gunson K,Jui J,Newton-Cheh C,Albert CM,Chugh SS

    更新日期：2013-07-01 00:00:00

  • Follow-up imaging after left atrial appendage closure.

    abstract：BACKGROUND:Because device-related thrombus (DRT) portends a poor prognosis after left atrial appendage closure with the Watchman device, surveillance transesophageal echocardiography (TEE) is recommended at 45 days and 1 year. However, oral anticoagulants are just discontinued at 45 days, rendering this early TEE unlik...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.06.024

    authors： Kuroki K,Doshi SK,Whang W,Vanderzee S,Ducharme CB,Enomoto Y,Hanon S,Koruth JS,Miller MA,Choudry S,Sofi A,Langan N,Ellsworth B,Dukkipati SR,Reddy VY

    更新日期：2020-11-01 00:00:00

  • Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice.

    abstract：BACKGROUND:Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy. OBJECTIVE:The purpose of this study was to (1) determine the value of ECG criteria to predict an epicardial SoO of clinical...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2014.03.001

    authors： Piers SR,Silva Mde R,Kapel GF,Trines SA,Schalij MJ,Zeppenfeld K

    更新日期：2014-06-01 00:00:00

  • Characteristics of ectopic triggers associated with paroxysmal and persistent atrial fibrillation: evidence for a changing role.

    abstract：BACKGROUND:Atrial premature contractions (APCs) are well described to precede the initiation of paroxysmal atrial fibrillation (pAF). However, whether APC characteristics alter with progression of the arrhythmia is unknown. OBJECTIVE:To determine the APC characteristics in terms of burden and relative coupling interva...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2012.03.062

    authors： Brooks AG,Rangnekar G,Ganesan AN,Salna I,Middeldorp ME,Kuklik P,Baumert M,Roberts-Thomson KC,Sanders P

    更新日期：2012-09-01 00:00:00

  • Transthoracic percutaneous access for electroanatomic mapping and catheter ablation of atrial tachycardia in patients with a lateral tunnel Fontan.

    abstract：BACKGROUND:The incidence of atrial tachycardia following Fontan surgery is high, but access to the pulmonary venous atrium, a frequent site of arrhythmia origin, is limited. OBJECTIVES:The purpose of this study is to report our results with a novel transthoracic percutaneous technique that provides direct access to th...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2005.09.027

    authors： Nehgme RA,Carboni MP,Care J,Murphy JD

    更新日期：2006-01-01 00:00:00

  • Implantable cardioverter-defibrillators in lamin A/C mutation carriers with cardiac conduction disorders.

    abstract：BACKGROUND:Sudden cardiac death is frequent in patients with lamin A/C gene (LMNA) mutations and may be related to ventricular arrhythmias (VA). OBJECTIVE:To evaluate a strategy of prophylactic implantable cardioverter-defibrillator (ICD) implantation in LMNA mutation carriers with significant cardiac conduction disor...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2013.06.020

    authors： Anselme F,Moubarak G,Savouré A,Godin B,Borz B,Drouin-Garraud V,Gay A

    更新日期：2013-10-01 00:00:00

  • Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study.

    abstract：BACKGROUND:Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. OBJECTIVES:We investigated whether atrial effective refractory pe...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2016.03.037

    authors： Lee JM,Lee H,Janardhan AH,Park J,Joung B,Pak HN,Lee MH,Kim SS,Hwang HJ

    更新日期：2016-08-01 00:00:00

  • Cardiac fibrillation: from ion channels to rotors in the human heart.

    abstract：:Recent new information on the dynamics and molecular mechanisms of electrical rotors and spiral waves has increased our understanding of both atrial fibrillation and ventricular fibrillation. In this brief review, we evaluate the available evidence for the separate roles played by individual sarcolemmal ion channels i...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2008.02.034

    authors： Vaquero M,Calvo D,Jalife J

    更新日期：2008-06-01 00:00:00

  • Mortality after cardioverter-defibrillator replacement: Results of the DECODE survival score index.

    abstract：BACKGROUND:Device replacement is the ideal time to reassess health care goals regarding continuing implantable cardioverter-defibrillator (ICD) therapy. Only few data are available on the decision making at this time. OBJECTIVES:The goals of this study were to identify factors associated with poor prognosis at the tim...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.11.024

    authors： Zoni-Berisso M,Martignani C,Ammendola E,Narducci ML,Caruso D,Miracapillo G,Notarstefano P,Carinci V,Pierantozzi A,Ciaramitaro G,Calò L,Zennaro M,Infusino T,Ferretti C,Sassone B,Licciardello G,Setti S,Terzaghi C,Malacr

    更新日期：2020-11-27 00:00:00

  • Minimally invasive surgical atrial fibrillation ablation: patient selection and results.

    abstract：:Minimally invasive surgical atrial fibrillation ablation (MISAA) is an emerging alternative to catheter ablation and the full surgical maze procedure for nonpharmacologic treatment of atrial fibrillation. MISAA offers the potential to provide highly effective pulmonary vein isolation, exclusion of the left atrial appe...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2009.07.027

    authors： Han FT,Kasirajan V,Wood MA,Ellenbogen KA

    更新日期：2009-12-01 00:00:00

  • Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome.

    abstract：BACKGROUND:There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). OBJECTIVE:The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS an...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2019.07.003

    authors： Milman A,Andorin A,Postema PG,Gourraud JB,Sacher F,Mabo P,Kim SH,Maeda S,Takahashi Y,Kamakura T,Aiba T,Conte G,Juang JJM,Leshem E,Michowitz Y,Fogelman R,Hochstadt A,Mizusawa Y,Giustetto C,Arbelo E,Huang Z,Corrad

    更新日期：2019-10-01 00:00:00

  • Discriminating atrial flutter from atrial fibrillation using a multilevel model of atrioventricular conduction.

    abstract：BACKGROUND:The discrimination between atrial flutter (AFlu) and atrial fibrillation (AFib) can be made difficult by an irregular ventricular response owing to complex conduction phenomena within the atrioventricular (AV) node, known as multilevel AV block. We tested the hypothesis that a mathematical algorithm might be...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2014.02.013

    authors： Scholz EP,Kehrle F,Vossel S,Hess A,Zitron E,Katus HA,Sager S

    更新日期：2014-05-01 00:00:00

  • Safety and efficacy of epicardial cryoablation in a canine model.

    abstract：OBJECTIVES:The purpose of this study was to evaluate the safety and efficacy of cryoablation in a closed chest canine epicardial ablation model. BACKGROUND:Limitations of radiofrequency energy in the epicardial space warrants investigation of alternative energy sources. METHODS:A linear-tip catheter with a 3-cm freez...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2004.09.022

    authors： Lustgarten DL,Bell S,Hardin N,Calame J,Spector PS

    更新日期：2005-01-01 00:00:00

  • High-intensity ultrasound catheter ablation achieves deep mid-myocardial lesions in vivo.

    abstract：BACKGROUND:Radiofrequency ablation of epicardial and mid-myocardial ventricular arrhythmias is limited by lesion depth. OBJECTIVE:The purpose of this study was to generate deep mid-interventricular septal (IVS) lesions using high-intensity ultrasound (US) from an endocardial catheter-based approach. METHODS:Irrigated...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.12.027

    authors： Nazer B,Giraud D,Zhao Y,Hodovan J,Elman MR,Masri A,Gerstenfeld EP,Lindner JR

    更新日期：2020-12-29 00:00:00

  • Cardiac magnetic resonance imaging using wideband sequences in patients with nonconditional cardiac implanted electronic devices.

    abstract：BACKGROUND:Magnetic resonance imaging (MRI) has been performed safely in patients without MRI-conditional cardiac implantable electronic devices (CIEDs), but experience specifically with cardiac magnetic resonance imaging (CMR) is limited in this patient population. OBJECTIVE:Evaluate the safety of CMR in non-MRI-cond...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2017.10.003

    authors： Do DH,Eyvazian V,Bayoneta AJ,Hu P,Finn JP,Bradfield JS,Shivkumar K,Boyle NG

    更新日期：2018-02-01 00:00:00

  • Interatrial conduction can be accurately determined using standard 12-lead electrocardiography: validation of P-wave morphology using electroanatomic mapping in man.

    abstract：BACKGROUND:Different P-wave morphologies during sinus rhythm as displayed on standard ECGs have been postulated to correspond to differences in interatrial conduction. OBJECTIVE:The purpose of this study was to evaluate the hypothesis by comparing P-wave morphologies using left atrial activation maps. METHODS:Twenty-...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2007.12.017

    authors： Holmqvist F,Husser D,Tapanainen JM,Carlson J,Jurkko R,Xia Y,Havmöller R,Kongstad O,Toivonen L,Olsson SB,Platonov PG

    更新日期：2008-03-01 00:00:00

  • Intracardiac QT integral on far-field ICD electrogram predicts sustained ventricular tachyarrhythmias in ICD patients.

    abstract：BACKGROUND:Prediction of sustained ventricular tachycardia (VT)/ventricular fibrillation (VF) could help to guide preventive interventions in at-risk patients. The QRST integral (∫QT) reflects intrinsic repolarization properties. OBJECTIVE:The objective of this study was to determine whether intracardiac ∫QT predicts ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.07.029

    authors： Tereshchenko LG,Ghanem RN,Abeyratne A,Swerdlow CD

    更新日期：2011-12-01 00:00:00

  • Sudden cardiac arrest in intercollegiate athletes: detailed analysis and outcomes of resuscitation in nine cases.

    abstract：BACKGROUND:Public access defibrillation programs have demonstrated a survival benefit in persons with out-of-hospital cardiac arrest. However, little is known about the effectiveness of early defibrillation in young competitive athletes with sudden cardiac arrest (SCA). OBJECTIVES:The purpose of this study was to inve...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2006.03.023

    authors： Drezner JA,Rogers KJ

    更新日期：2006-07-01 00:00:00

  • Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current.

    abstract：BACKGROUND:Membrane-associated guanylate kinase (MAGUK) proteins are important determinants of ion channel organization in the plasma membrane. In the heart, the MAGUK protein SAP97, encoded by the DLG1 gene, interacts with several ion channels via their PDZ domain-binding motif and regulates their function and localiz...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2014.09.057

    authors： Gillet L,Rougier JS,Shy D,Sonntag S,Mougenot N,Essers M,Shmerling D,Balse E,Hatem SN,Abriel H

    更新日期：2015-01-01 00:00:00

  • Ventricular tachycardia in cardiolaminopathy: Characteristics and considerations for device programming.

    abstract：BACKGROUND:Mutations in LMNA cause an arrhythmogenic cardiomyopathy (cardiolaminopathy) with high risk of ventricular tachycardia (VT). The natural history of VT among patients with cardiolaminopathy is incompletely understood. OBJECTIVE:The purpose of this study was to determine the longitudinal burden and progressio...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.05.023

    authors： Sidhu K,Han L,Picard KCI,Tedrow UB,Lakdawala NK

    更新日期：2020-10-01 00:00:00

  • Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing.

    abstract：BACKGROUND:Mutations in the RyR2-encoded cardiac ryanodine receptor/calcium release channel and in CASQ2-encoded calsequestrin cause catecholaminergic polymorphic ventricular tachycardia (CPVT1 and CPVT2, respectively). OBJECTIVES:The purpose of this study was to evaluate the extent of genotypic and phenotypic heterog...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2006.03.025

    authors： Tester DJ,Arya P,Will M,Haglund CM,Farley AL,Makielski JC,Ackerman MJ

    更新日期：2006-07-01 00:00:00

  • Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias.

    abstract：BACKGROUND:In normal atrial and ventricular tissue, the electrical wavefronts are mediated by the fast sodium current (I(Na)), whereas in sinoatrial and atrioventricular nodal tissue, conduction is mediated by the slow L-type calcium current (I(Ca,L)). However, it has not been shown whether the same tissue can exhibit ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.08.014

    authors： Chang MG,Sato D,de Lange E,Lee JH,Karagueuzian HS,Garfinkel A,Weiss JN,Qu Z

    更新日期：2012-01-01 00:00:00