当前位置： SCI文献检索 > HEART RHYTHM期刊下所有文献 > Optical capture and defibrillation in rats with monocrotaline-induced myocardial fibrosis 1 year after a single intravenous injection of adeno-associated virus channelrhodopsin-2.

Optical capture and defibrillation in rats with monocrotaline-induced myocardial fibrosis 1 year after a single intravenous injection of adeno-associated virus channelrhodopsin-2.

Abstract：

BACKGROUND:Optogenetics uses light to regulate cardiac rhythms and terminate malignant arrhythmias. OBJECTIVE:The purpose of this study was to investigate the long-term validity of optical capture properties based on virus-transfected channelrhodopsin-2 (ChR2) and evaluate the effects of optogenetic-based defibrillation in an in vivo rat model of myocardial fibrosis enhanced by monocrotaline (MCT). METHODS:Fifteen infant rats received jugular vein injection of adeno-associated virus (AAV). After 8 weeks, 5 rats were randomly selected to verify the effectiveness ChR2 transfection. The remaining rats were administered MCT at 11 months. Four weeks after MCT, the availability of 473-nm blue light to capture heart rhythm in these rats was verified again. Ventricular tachycardia (VT) and ventricular fibrillation (VF) were induced by burst stimulation on the basis of enhanced myocardial fibrosis, and the termination effects of the optical manipulation were tested. RESULTS:Eight weeks after AAV injection, there was ChR2 expression throughout the ventricular myocardium as reflected by both fluorescence imaging and optical pacing. Four weeks after MCT, significant myocardial fibrosis was achieved. Light could still trigger the corresponding ectopic heart rhythm, and the pulse width and illumination area could affect the light capture rate. VT/VF was induced successfully in 1-year-observation rats, and the rate of termination of VT/VF under light was much higher than that of spontaneous termination. CONCLUSION:Viral ChR2 transfection can play a long-term role in the rat heart, and light can successfully regulate heart rhythm and defibrillate after cardiac fibrosis.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Li J,Wang L,Luo J,Li H,Rao P,Cheng Y,Wang X,Huang C

doi

10.1016/j.hrthm.2020.08.002

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

109-117

issue

1

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(20)30755-4

journal_volume

18

pub_type

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