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Risk of atrial fibrillation as a function of the electrocardiographic PR interval: results from the Copenhagen ECG Study.

Abstract：

BACKGROUND:Prolongation of the PR interval has been associated with an increased risk of incident atrial fibrillation (AF). OBJECTIVE:To determine if there was a nonlinear relation between PR interval duration and the risk of AF. METHODS:We included 288,181 individuals, corresponding to one third of the population in the greater region of Copenhagen. These individuals had a digital electrocardiogram (ECG) recorded in a general practitioner's core facility from 2001 to 2010. Data on drug use, comorbidity, and outcomes were collected from Danish registries. RESULTS:During a median follow-up period of 5.7 years, 11,087 developed AF. Having a PR interval ≥95th percentile (≥196 ms for women, ≥204 ms for men) was associated with an increased risk of AF as evidenced by a multivariable-adjusted hazard ratio (HR) of 1.18 (95% confidence interval [CI] 1.06-1.30, P = .001) for women and 1.30 (1.17-1.44, P < .001) for men compared with the respective reference groups (PR interval between 40th and 60th percentile). Having a short PR interval <5th percentile (≤121 ms for women, ≤129 ms for men) was also associated with an increased risk of AF for women (HR 1.32, 95% CI 1.12-1.56, P = .001), but this was not significant for men (HR 1.09, 95% CI 0.92-1.29, P = .33). CONCLUSION:In this large ECG study, we found an increased risk of AF for longer PR intervals for both women and men. With respect to short PR intervals, we also observed an increased risk of AF for women.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Nielsen JB,Pietersen A,Graff C,Lind B,Struijk JJ,Olesen MS,Haunsø S,Gerds TA,Ellinor PT,Køber L,Svendsen JH,Holst AG

doi

10.1016/j.hrthm.2013.04.012

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1249-56

issue

9

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(13)00434-7

journal_volume

10

pub_type

杂志文章

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