Abstract:
BACKGROUND:Ventricular arrhythmias (VAs) in cardiac sarcoidosis (CS) are frequently refractory to both antiarrhythmic drug (AAD) therapy and catheter ablation (CA). Cardiac sympathetic denervation (CSD) has been shown to reduce VA burden and implantable cardioverter-defibrillator (ICD) shocks in patients with nonischemic cardiomyopathy. OBJECTIVE:We aimed to report our center's preliminary experience with CSD in patients with known or presumed CS and refractory VAs. METHODS:Patients with CS and refractory VAs who underwent CSD at our institution were included. Patient characteristics, procedural outcomes, and number of arrhythmic events including ICD shocks pre- and post-CSD are reported. RESULTS:Five patients with CS (mean age 53 ± 11 years; 2 men [40%]; mean left ventricular ejection fraction 38% ± 11%) underwent CSD for VA refractory to AAD therapy and CA. Four of 5 patients underwent bilateral CSD; 1 patient underwent right-sided sympathectomy only because of poor intraoperative visualization on the left. Procedural complications included hemothorax in 1 patient and azygous vein injury in 1 patient. The median number of ICD shocks in the 6 months pre-CSD was 5. During a median follow-up of 26 months (range 5-29 months), the median number of ICD shocks post-CSD was 0; 1 patient had sustained VA that was below the threshold for device therapy, and 1 patient had symptomatic premature ventricular contractions; both underwent repeat CA. In addition, 1 patient required cardiac transplantation for progressive heart failure. CONCLUSION:CSD may be a feasible therapeutic adjunct for patients with CS and VA refractory to AAD therapy and CA.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Okada DR,Assis FR,Gilotra NA,Ha JS,Berger RD,Calkins H,Chrispin J,Mandal K,Tandri Hdoi
10.1016/j.hrthm.2019.02.025subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1408-1413issue
9eissn
1547-5271issn
1556-3871pii
S1547-5271(19)30147-Xjournal_volume
16pub_type
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