Abstract:
:Since the discovery of atrial natriuretic peptide (ANP) in 1981, significant progress has been made in understanding the mechanism of its release and its role in salt and water balance in the body. It has also become clear that ANP plays a key role in cardiac electrophysiology, modulating the autonomic nervous system and regulating the function of cardiac ion channels. The clinical importance of this role was established when mutations in NPPA, the gene encoding ANP, were identified as a cause of familial atrial fibrillation. This review examines our current understanding of the electrophysiological effects of ANP, and their physiological relationship to clinical studies linking ANP and atrial fibrillation.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Perrin MJ,Gollob MHdoi
10.1016/j.hrthm.2011.11.019subject
Has Abstractpub_date
2012-04-01 00:00:00pages
610-5issue
4eissn
1547-5271issn
1556-3871pii
S1547-5271(11)01338-5journal_volume
9pub_type
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