The role of atrial natriuretic peptide in modulating cardiac electrophysiology.

Abstract:

:Since the discovery of atrial natriuretic peptide (ANP) in 1981, significant progress has been made in understanding the mechanism of its release and its role in salt and water balance in the body. It has also become clear that ANP plays a key role in cardiac electrophysiology, modulating the autonomic nervous system and regulating the function of cardiac ion channels. The clinical importance of this role was established when mutations in NPPA, the gene encoding ANP, were identified as a cause of familial atrial fibrillation. This review examines our current understanding of the electrophysiological effects of ANP, and their physiological relationship to clinical studies linking ANP and atrial fibrillation.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Perrin MJ,Gollob MH

doi

10.1016/j.hrthm.2011.11.019

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

610-5

issue

4

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(11)01338-5

journal_volume

9

pub_type

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