Abstract:
:Aortic stenosis (AS) is the most common primary valve disorder in the elderly with an increasing prevalence. It is increasingly clear that it is also a disease of the left ventricle (LV) rather than purely the aortic valve. The transition from left ventricular hypertrophy to fibrosis results in the eventual adverse effects on systolic and diastolic function. Appropriate selection of patients for aortic valve intervention is crucial, and current guidelines recommend aortic valve replacement in severe AS with symptoms or in asymptomatic patients with left ventricular ejection fraction (LVEF) <50 %. LVEF is not a sensitive marker and there are other parameters used in multimodality imaging techniques, including longitudinal strain, exercise stress echo and cardiac MRI that may assist in detecting subclinical and subtle LV dysfunction. These findings offer potentially better ways to evaluate patients, time surgery, predict recovery and potentially offer targets for specific therapies. This article outlines the pathophysiology behind the LV response to aortic stenosis and the role of advanced multimodality imaging in describing it.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Badiani S,van Zalen J,Treibel TA,Bhattacharyya S,Moon JC,Lloyd Gdoi
10.1007/s11886-016-0753-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
80issue
8eissn
1523-3782issn
1534-3170pii
10.1007/s11886-016-0753-6journal_volume
18pub_type
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