Aortic Stenosis, a Left Ventricular Disease: Insights from Advanced Imaging.

Abstract:

:Aortic stenosis (AS) is the most common primary valve disorder in the elderly with an increasing prevalence. It is increasingly clear that it is also a disease of the left ventricle (LV) rather than purely the aortic valve. The transition from left ventricular hypertrophy to fibrosis results in the eventual adverse effects on systolic and diastolic function. Appropriate selection of patients for aortic valve intervention is crucial, and current guidelines recommend aortic valve replacement in severe AS with symptoms or in asymptomatic patients with left ventricular ejection fraction (LVEF) <50 %. LVEF is not a sensitive marker and there are other parameters used in multimodality imaging techniques, including longitudinal strain, exercise stress echo and cardiac MRI that may assist in detecting subclinical and subtle LV dysfunction. These findings offer potentially better ways to evaluate patients, time surgery, predict recovery and potentially offer targets for specific therapies. This article outlines the pathophysiology behind the LV response to aortic stenosis and the role of advanced multimodality imaging in describing it.

journal_name

Curr Cardiol Rep

authors

Badiani S,van Zalen J,Treibel TA,Bhattacharyya S,Moon JC,Lloyd G

doi

10.1007/s11886-016-0753-6

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

80

issue

8

eissn

1523-3782

issn

1534-3170

pii

10.1007/s11886-016-0753-6

journal_volume

18

pub_type

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