Abstract：
:Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Fan L,Hu C,Chen J,Cen P,Wang J,Li Ldoi
10.3390/ijms17050650subject
Has Abstractpub_date
2016-05-05 00:00:00issue
5issn
1422-0067pii
ijms17050650journal_volume
17pub_type
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