当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > pH-Responsive Hyaluronic Acid-Based Mixed Micelles for the Hepatoma-Targeting Delivery of Doxorubicin.

pH-Responsive Hyaluronic Acid-Based Mixed Micelles for the Hepatoma-Targeting Delivery of Doxorubicin.

Abstract：

:The tumor targetability and stimulus responsivity of drug delivery systems are crucial in cancer diagnosis and treatment. In this study, hepatoma-targeting mixed micelles composed of a hyaluronic acid-glycyrrhetinic acid conjugate and a hyaluronic acid-l-histidine conjugate (HA-GA/HA-His) were prepared through ultrasonic dispersion. The formation and characterization of the mixed micelles were confirmed via ¹H-NMR, particle size, and ζ potential measurements. The in vitro cellular uptake of the micelles was evaluated using human liver carcinoma (HepG2) cells. The antitumor effect of doxorubicin (DOX)-loaded micelles was investigated in vitro and in vivo. Results indicated that the DOX-loaded HA-GA/HA-His micelles showed a pH-dependent controlled release and were remarkably absorbed by HepG2 cells. Compared with free DOX, the DOX-loaded HA-GA/HA-His micelles showed a higher cytotoxicity to HepG2 cells. Moreover, the micelles effectively inhibited tumor growth in H22 cell-bearing mice. These results suggest that the HA-GA/HA-His mixed micelles are a good candidate for drug delivery in the prevention and treatment of hepatocarcinoma.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Wu JL,Tian GX,Yu WJ,Jia GT,Sun TY,Gao ZQ

doi

10.3390/ijms17040364

subject

Has Abstract

pub_date

2016-03-30 00:00:00

pages

364

issue

4

issn

1422-0067

pii

ijms17040364

journal_volume

17

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Investigation on the Interactions between Self-Assembled β-Sheet Peptide Nanofibers and Model Cell Membranes.

    abstract：:Self-assembled peptide nanofibers (NFs) obtained from β-sheet peptides conjugated with drugs, including antigenic peptides, have recently attracted significant attention. However, extensive studies on the interactions of β-sheet peptide NFs with model cell membranes have not been reported. In this study, we investigat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249518

    authors： Waku T,Kasai A,Kobori A,Tanaka N

    更新日期：2020-12-14 00:00:00

  • Chromosome Missegregation in Single Human Oocytes Is Related to the Age and Gene Expression Profile.

    abstract：:The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of aneuploid pregnancies. Despite the importance to human reproductive health, the events precipitating female age-related meiotic errors are poorly understood. To gain new insight into the molecular basis of age-...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21061934

    authors： Barone S,Sarogni P,Valli R,Pallotta MM,Silvia G,Frattini A,Khan AW,Rapalini E,Parri C,Musio A

    更新日期：2020-03-12 00:00:00

  • Roles of rho GTPases in intracellular transport and cellular transformation.

    abstract：:Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms14047089

    authors： Chi X,Wang S,Huang Y,Stamnes M,Chen JL

    更新日期：2013-03-28 00:00:00

  • The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis.

    abstract：:The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155209

    authors： Jasinski-Bergner S,Steven A,Seliger B

    更新日期：2020-07-23 00:00:00

  • The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester.

    abstract：:Creatine is a metabolite important for cellular energy homeostasis as it provides spatio-temporal adenosine triphosphate (ATP) buffering for cells with fluctuating energy demands. Here, we examined whether placental creatine metabolism was altered in cases of early-onset pre-eclampsia (PE), a condition known to cause ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21030806

    authors： Ellery SJ,Murthi P,Gatta PAD,May AK,Davies-Tuck ML,Kowalski GM,Callahan DL,Bruce CR,Wallace EM,Walker DW,Dickinson H,Snow RJ

    更新日期：2020-01-26 00:00:00

  • The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer.

    abstract：:Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory enzymes involved in cell proliferation through regulating cell-cycle checkpoints and transcriptional events in response to extracellular ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21061960

    authors： Ding L,Cao J,Lin W,Chen H,Xiong X,Ao H,Yu M,Lin J,Cui Q

    更新日期：2020-03-13 00:00:00

  • Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis.

    abstract：:Chorea acanthocytosis (ChAc), an ultra-rare devastating neurodegenerative disease, is caused by mutations in the VPS13A gene, which encodes for the protein chorein. Affected patients suffer from chorea, orofacial dyskinesia, epilepsy, parkinsonism as well as peripheral neuropathy. Although medium spinal neurons of the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051797

    authors： Glaß H,Neumann P,Pal A,Reinhardt P,Storch A,Sterneckert J,Hermann A

    更新日期：2020-03-05 00:00:00

  • Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy.

    abstract：:Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report con...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms131114385

    authors： Hum JM,Siegel AP,Pavalko FM,Day RN

    更新日期：2012-11-07 00:00:00

  • Immune-Specific Expression and Estrogenic Regulation of the Four Estrogen Receptor Isoforms in Female Rainbow Trout (Oncorhynchus mykiss).

    abstract：:Genomic actions of estrogens in vertebrates are exerted via two intracellular estrogen receptor (ER) subtypes, ERα and ERβ, which show cell- and tissue-specific expression profiles. Mammalian immune cells express ERs and are responsive to estrogens. More recently, evidence became available that ERs are also present in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19040932

    authors： Casanova-Nakayama A,Wernicke von Siebenthal E,Kropf C,Oldenberg E,Segner H

    更新日期：2018-03-21 00:00:00

  • Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms.

    abstract：:Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatri...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17040461

    authors： Hernández AF,Menéndez P

    更新日期：2016-03-29 00:00:00

  • Expression of Sox2 and Oct4 and their clinical significance in human non-small-cell lung cancer.

    abstract：:Sox2 and Oct4 are transcription factors with the characteristics of regulating self-renewal and differentiation of embryonic stem cell. The aim of this study was to detect the expression of Sox2 and Oct4 and analyze their clinical significance in human non-small-cell lung cancer (NSCLC). Expression of Sox2 and Oct4 we...

    journal_title：International journal of molecular sciences

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.3390/ijms13067663

    authors： Li X,Wang J,Xu Z,Ahmad A,Li E,Wang Y,Qin S,Wang Q

    更新日期：2012-01-01 00:00:00

  • The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis.

    abstract：:Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets share clinical phenot...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21176401

    authors： Tsukazaki H,Kaito T

    更新日期：2020-09-03 00:00:00

  • Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects.

    abstract：:Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced to control toxicity caused by its rapid natural corrosion. In the process of developing new Mg alloys with various surface modifications, an efficient assessment of ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020971

    authors： Hartjen P,Wegner N,Ahmadi P,Matthies L,Nada O,Fuest S,Yan M,Knipfer C,Gosau M,Walther F,Smeets R

    更新日期：2021-01-19 00:00:00

  • Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer's Disease (AD): A Systematic Review and Meta-Analysis.

    abstract：:Findings from previous studies reporting the levels of serum brain-derived neurotrophic factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI) have been conflicting. Hence, we performed a meta-analysis to examine the aggregate levels of serum BDNF in patients with ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,meta分析

    doi：10.3390/ijms20020257

    authors： Ng TKS,Ho CSH,Tam WWS,Kua EH,Ho RC

    更新日期：2019-01-10 00:00:00

  • Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies.

    abstract：:Alzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020493

    authors： Zhang XW,Chen JY,Ouyang D,Lu JH

    更新日期：2020-01-13 00:00:00

  • Mechanisms of PKA-Dependent Potentiation of Kv7.5 Channel Activity in Human Airway Smooth Muscle Cells.

    abstract：:β-adrenergic receptor (βAR) activation promotes relaxation of both vascular and airway smooth muscle cells (VSMCs and ASMCs, respectively), though the signaling mechanisms have not been fully elucidated. We previously found that the activity of Kv7.5 voltage-activated potassium channels in VSMCs is robustly enhanced b...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19082223

    authors： Brueggemann LI,Cribbs LL,Schwartz J,Wang M,Kouta A,Byron KL

    更新日期：2018-07-30 00:00:00

  • Chromatin dynamics during nucleotide excision repair: histones on the move.

    abstract：:It has been a long-standing question how DNA damage repair proceeds in a nuclear environment where DNA is packaged into chromatin. Several decades of analysis combining in vitro and in vivo studies in various model organisms ranging from yeast to human have markedly increased our understanding of the mechanisms underl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms130911895

    authors： Adam S,Polo SE

    更新日期：2012-01-01 00:00:00

  • Current Insights in Elucidation of Possible Molecular Mechanisms of the Juvenile Form of Batten Disease.

    abstract：:The neuronal ceroid lipofuscinoses (NCLs) collectively constitute one of the most common forms of inherited childhood-onset neurodegenerative disorders. They form a heterogeneous group of incurable lysosomal storage diseases that lead to blindness, motor deterioration, epilepsy, and dementia. Traditionally the NCL dis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21218055

    authors： Shematorova EK,Shpakovski GV

    更新日期：2020-10-29 00:00:00

  • Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma.

    abstract：:Hypoxia inducible factor 1 (HIF-1) is a transcription factor composed of two subunits, namely, HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several hypoxia-responsive proteins, including angiogenesis factors, glycolysis solution enzymes, and cell survival proteins. HIF-1 is also as...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17060799

    authors： Li N,Li Y,Li Z,Huang C,Yang Y,Lang M,Cao J,Jiang W,Xu Y,Dong J,Ren H

    更新日期：2016-06-03 00:00:00

  • Profile of Polyphenol Compounds of Five Muscadine Grapes Cultivated in the United States and in Newly Adapted Locations in China.

    abstract：:Polyphenol compositions and concentrations in skins and seeds of five muscadine grapes (cv. "Noble", "Alachua", "Carlos", "Fry", and "Granny Val") cultivated in the United States (Tallahassee-Florida, TA-FL) and South China (Nanning-Guangxi, NN-GX and Pu'er-Yunnan, PE-YN) were investigated, using ultra performance liq...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18030631

    authors： Wei Z,Luo J,Huang Y,Guo W,Zhang Y,Guan H,Xu C,Lu J

    更新日期：2017-03-14 00:00:00

  • RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis.

    abstract：:According to recent estimates, 2%-15% of couples are sterile, and approximately half of the infertility cases are attributed to male reproductive factors. However, the reasons remain undefined in approximately 25% of male infertility cases, and most infertility cases exhibit spermatogenic defects. Numerous genes invol...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18010097

    authors： Lin YH,Ke CC,Wang YY,Chen MF,Chen TM,Ku WC,Chiang HS,Yeh CH

    更新日期：2017-01-05 00:00:00

  • Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.

    abstract：:The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18122687

    authors： Melo S,Figueiredo J,Fernandes MS,Gonçalves M,Morais-de-Sá E,Sanches JM,Seruca R

    更新日期：2017-12-12 00:00:00

  • Confocal Spectroscopy to Study Dimerization, Oligomerization and Aggregation of Proteins: A Practical Guide.

    abstract：:Protein self-association is a key feature that can modulate the physiological role of proteins or lead to deleterious effects when uncontrolled. Protein oligomerization is a simple way to modify the activity of a protein, as the modulation of binding interfaces allows for self-activation or inhibition, or variation in...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17050655

    authors： Gambin Y,Polinkovsky M,Francois B,Giles N,Bhumkar A,Sierecki E

    更新日期：2016-04-30 00:00:00

  • Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.

    abstract：:Accumulating evidence indicates that oxidative stress plays a critical role in initiating the progression of inflammatory and fibrotic liver diseases, including cholestatic hepatitis. Peroxiredoxin 4 (PRDX4) is a secretory antioxidase that protects against oxidative damage by scavenging reactive oxygen species (ROS) i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19092509

    authors： Zhang J,Guo X,Hamada T,Yokoyama S,Nakamura Y,Zheng J,Kurose N,Ishigaki Y,Uramoto H,Tanimoto A,Yamada S

    更新日期：2018-08-24 00:00:00

  • Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia.

    abstract：:Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer's disease and their gene expression (amylo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21134599

    authors： Pluta R,Ułamek-Kozioł M,Januszewski S,Czuczwar SJ

    更新日期：2020-06-28 00:00:00

  • Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry.

    abstract：:Evidence suggests that high-density lipoprotein (HDL) components distinct from cholesterol, such as sphingosine-1-phosphate (S1P), may account for the anti-atherothrombotic effects attributed to this lipoprotein. The current method for the determination of plasma levels of S1P as well as levels associated with HDL par...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18081800

    authors： Egom EE,Fitzgerald R,Canning R,Pharithi RB,Murphy C,Maher V

    更新日期：2017-08-18 00:00:00

  • Effect of Water Chemistry on Antimony Removal by Chemical Coagulation: Implications of ζ-Potential and Size of Precipitates.

    abstract：:The process of coagulation and precipitation affect the fate and mobility of antimony (Sb) species in drinking water. Moreover, the solubility and physico-chemical properties of the precipitates may be affected by the media chemistry. Accordingly, the present study aimed to investigate the removal of Sb(III, V) specie...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20122945

    authors： Inam MA,Khan R,Akram M,Khan S,Yeom IT

    更新日期：2019-06-17 00:00:00

  • The Role of the Microbiome in Oral Squamous Cell Carcinoma with Insight into the Microbiome-Treatment Axis.

    abstract：:Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21218061

    authors： Sami A,Elimairi I,Stanton C,Ross RP,Ryan CA

    更新日期：2020-10-29 00:00:00

  • Molecular Effects of Irradiation (Cobalt-60) on the Control of Panonychus citri (Acari: Tetranychidae).

    abstract：:The effective dose of irradiation to control pest mites in quarantine has been studied extensively, but the molecular mechanisms underlying the effects of the irradiation on mites are largely unknown. In this study, exposure to 400 Gy of γ rays had significant (p < 0.05) effects on the adult survival, fecundity and eg...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161126004

    authors： Zhang K,Luo L,Chen X,Hu M,Hu Q,Gong L,Weng Q

    更新日期：2015-11-11 00:00:00

  • Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers.

    abstract：:Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins co...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093096

    authors： Buttacavoli M,Albanese NN,Roz E,Pucci-Minafra I,Feo S,Cancemi P

    更新日期：2020-04-28 00:00:00