Abstract:
AIMS:Few studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts. METHODS:The Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other psychoses (ICD 8-10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years. RESULTS:An increase in the cumulative incidence of all psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other psychoses. Earlier onset of cases and relatively more psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86-4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors. CONCLUSIONS:Surprisingly, increase in the cumulative incidence of psychosis and also changes in the types of psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
journal_name
Epidemiol Psychiatr Scijournal_title
Epidemiology and psychiatric sciencesauthors
Filatova S,Marttila R,Koivumaa-Honkanen H,Nordström T,Veijola J,Mäki P,Khandaker GM,Isohanni M,Jääskeläinen E,Moilanen K,Miettunen Jdoi
10.1017/S2045796016000123subject
Has Abstractpub_date
2017-06-01 00:00:00pages
314-324issue
3eissn
2045-7960issn
2045-7979pii
S2045796016000123journal_volume
26pub_type
杂志文章abstract:AIMS:Young adults with early psychosis want to pursue normal roles - education and employment. This paper summarises the empirical literature on the effectiveness of early intervention programmes for employment and education outcomes. METHODS:We conducted a systematic review of employment/education outcomes for early ...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000419
更新日期:2015-10-01 00:00:00
abstract::Increasing numbers of young adults need continued support for their attention deficit hyperactivity disorder (ADHD) beyond the age-boundary for children's services. The sparse literature on transition in general suggests patchy provision and huge gaps in transitional care, but also that young people with ADHD and othe...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796019000817
更新日期:2020-01-09 00:00:00
abstract::Aims. Prevalence and covariates of subclinical psychosis have gained increased interest in the context of early identification and treatment of persons at risk for psychosis. Methods. We analysed 9829 adults representative of the general population within the canton of Zurich, Switzerland. Two psychosis syndromes, der...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000681
更新日期:2015-02-01 00:00:00
abstract::The principle of pragmatism in clinical trials has been broadly recognised as a way to close the gap between research and practice. In this contribution, we argue that the conduct of pragmatic clinical trials in Europe may be hampered by poor implementation of current European Union's Clinical Trial Regulation No. 536...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020000396
更新日期:2020-05-06 00:00:00
abstract::This editorial discusses the application of a novel brain imaging analysis technique in the assessment of neuroanatomical dysconnectivity in psychotic illnesses. There has long been a clinical interest in psychosis as a disconnection syndrome. In recent years graph theory metrics have been applied to functional and st...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796015000074
更新日期:2015-08-01 00:00:00
abstract:AIMS:Establishing the minimum clinically important difference (MCID) in functioning and cognition is essential to the interpretation of the research and clinical work conducted in bipolar disorders (BD). The present study aimed to estimate the MCID for the Functioning Assessment Short Test (FAST) and a battery of neuro...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020000566
更新日期:2020-07-20 00:00:00
abstract:AIMS:To examine the impact of multiple psychiatric disorders over the lifetime on risk of mortality in the general population. METHODS:Data came from a random community-based sample of 1397 adults in Atlantic Canada, recruited in 1992. Major depression, dysthymia, panic disorder, generalised anxiety disorder and alcoh...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796018000859
更新日期:2019-02-04 00:00:00
abstract:BACKGROUND:Aims of this study are to explore the associations of readmission to psychiatric hospital over time, to develop a statistical model for early readmission to psychiatric hospital and to assess the feasibility of predicting early readmission. METHOD:The sample comprised 7891 general psychiatric discharges in ...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796015000128
更新日期:2016-04-01 00:00:00
abstract::Randomized controlled trials (RCTs), typically, randomize participants to one of two intervention groups. It has been shown, however, that about 25% of RCTs published in the scientific literature randomize participants to three or more treatment groups. These studies are called 'multi-arm' trials: there may be, for in...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000231
更新日期:2013-09-01 00:00:00
abstract::A recent meta-analysis of antidepressant trials is the largest conducted to date. Although it claims to prove antidepressant effectiveness beyond dispute, the main outcome is response rates, which are derived from continuous data in a process that can inflate differences between groups. The standardised mean differenc...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796018000240
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Studies in urban areas identified environmental risk factors for mental illness, but little research on this topic has been performed in rural areas. METHODS:Hospital admission rates were computed for 174 rural municipalities in the catchment area of the state psychiatric hospital in Günzburg in years 2006 ...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796012000157
更新日期:2012-12-01 00:00:00
abstract:AIMS:The association between Kawasaki disease (KD) and Attention deficit hyperactivity disorder (ADHD) has rarely been studied. In this study, we investigated the hypothesis that KD may increase the risk of ADHD using a nationwide Taiwanese population-based claims database. METHODS:Our study cohort consisted of patien...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796015000840
更新日期:2016-12-01 00:00:00
abstract::When developing accessible, affordable and effective mental health systems, exchange of data between countries is an important moving force towards better mental health care. Unfortunately, health information systems in most countries are weak in the field of mental health, and comparability of data is low. Special in...
journal_title:Epidemiology and psychiatric sciences
pub_type: 社论
doi:10.1017/s2045796011000060
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The primary goal was to identify risk factors for post-surgical depression in subjects operated on for drug-resistant epilepsy. Secondary goals were to confirm the high rate of depression in subjects suffering from epilepsy (prior to surgery) and to look for first post-surgical depressive episode. METHODS:Ca...
journal_title:Epidemiology and psychiatric sciences
pub_type: 信件
doi:10.1017/s2045796011000175
更新日期:2011-03-01 00:00:00
abstract:AIMS:The purpose of this review is to examine the replication attempts of psychotherapy clinical trials for depression and anxiety. We focus specifically on replications of trials that exhibit large differences between psychotherapies. The replicability of these trials is especially important for meta-analysis, where t...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S2045796020000402
更新日期:2020-05-15 00:00:00
abstract:AIMS:To explore the role of psychiatric admission, diagnosis and reported unfair treatment in the relationship between ethnicity and mistrust of mental health services. METHODS:The Mental Illness-Related Investigations on Discrimination (MIRIAD) study was a cross-sectional study of 202 individuals using secondary ment...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000158
更新日期:2015-06-01 00:00:00
abstract::The use of psychoactive, potentially dependence-producing substances is highly prevalent around the world, and contributes substantially to global disease burden. There is a major gap between the need for treatment for substance use disorders. Changes proposed for the classification of substance use disorders in the E...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796017000622
更新日期:2018-06-01 00:00:00
abstract:AIMS:Incorporating consumer perspectives into mental health services design is important in working to deliver recovery-oriented care. One of the challenges faced in mental health rehabilitation services is limited consumer engagement with the available support. Listening to consumers' expectations of mental health ser...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796017000749
更新日期:2019-08-01 00:00:00
abstract::With cancer incidence increasing over time worldwide, attention to the burden of psychiatric and psychosocial consequences of the disease is now mandatory for both cancer and mental health care professionals. Psychiatric disorders have been shown to affect at least 30-35% of cancer patients during all phases of the di...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796019000866
更新日期:2020-01-09 00:00:00
abstract:AIMS:To study the potential use of child behaviour checklist (CBCL) 1.5-5 scales for the early identification of preschoolers at risk of autism. METHODS:CBCL scores of three groups of preschoolers were compared: (1) an experimental group of 101 preschoolers with autism spectrum disorder (ASD); (2) a control group of 9...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/s204579601100045x
更新日期:2011-12-01 00:00:00
abstract::Aims. High numbers of psychiatric service users experience domestic violence, yet limited interventions exist for these victims. We piloted a domestic violence intervention for community mental health services to explore the feasibility of a future cluster randomized controlled trial. Methods. Quasi-experimental contr...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000206
更新日期:2014-03-01 00:00:00
abstract:AIMS:Decades of research show that people with schizophrenia have an increased risk of death from cancer; however, the relationship between schizophrenia and cancer incidence remains less clear. This population-based study investigates the incidence of seven common types of cancer among people with a hospital diagnosis...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579602000044X
更新日期:2020-05-28 00:00:00
abstract:AIM:Eating disorders have increasingly become a public health concern globally. This study aimed to reveal the burden of eating disorders at the global, regional and national levels using the Global Burden of Disease (GBD) Study 2017 data. METHODS:We extracted the age-standardised rates (ASRs) of prevalence and disabi...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020001055
更新日期:2020-12-07 00:00:00
abstract::Mental health care in the second half of the 20th century in much of the developed world has been dominated by the move out from large asylums. Both in response to this move and to make it possible, a pattern of care has evolved which is most commonly referred to as 'Community Psychiatry'. This narrative review descri...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000560
更新日期:2014-12-01 00:00:00
abstract:AIMS:This systematic review compiled evidence on interventions to reduce mental health-related stigma among medical and nursing students in low- and middle-income countries (LMICs). Primary outcomes were stigmatising attitudes and discriminatory behaviours. METHODS:Data collection included two strategies. First, previ...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796019000167
更新日期:2019-04-01 00:00:00
abstract::Background. Interest in features of our local environments that may promote better mental health and wellbeing continues to rise among decision makers. Our purpose was to highlight a selection of these challenges and some promising avenues for enhancing the quality of evidence. Method. An analysis of approximately 267...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579601400050X
更新日期:2015-02-01 00:00:00
abstract::Psychiatry is having a great time. Over the last few years, we have seen an exceptional explosion in neuroscience knowledge, and especially in our understanding of the molecular mechanisms through which environmental and genetic factors affect the brain and regulate behaviour, while at the same interacting with periph...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579601500089X
更新日期:2016-04-01 00:00:00
abstract::Within mental health care, 'person-centredness' has been generally interpreted to convey a holistic approach with an attitude of respect for the individual and his/her unique experience and needs. Although it has been possible to demonstrate that professionals can acquire such skills through training, the impact on cl...
journal_title:Epidemiology and psychiatric sciences
pub_type: 社论
doi:10.1017/S2045796012000078
更新日期:2012-06-01 00:00:00
abstract:AIMS:The use of Alzheimer disease medication for the treatment of dementia symptoms has shown significant benefits with regards to functional and cognitive outcomes as well as nursing home placement (NHP) and mortality. Hospitalisations in these patient groups are characterised by extended length of stays (LOS), freque...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796019000702
更新日期:2019-11-14 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterised by deficits in social communication as well as by narrow patterns of behaviour and interests (American Psychiatric Association, 2013), often accompanied by language, intellectual and sensory impairments. The severity of these impairme...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796017000610
更新日期:2018-04-01 00:00:00