What does the latest meta-analysis really tell us about antidepressants?

Abstract:

:A recent meta-analysis of antidepressant trials is the largest conducted to date. Although it claims to prove antidepressant effectiveness beyond dispute, the main outcome is response rates, which are derived from continuous data in a process that can inflate differences between groups. The standardised mean difference of 0.3 is in line with other meta-analyses that show small differences between antidepressants and placebo that are unlikely to be clinically significant. Other factors likely to exaggerate the effects are discussed, and evidence on associations between antidepressant effects and severity and outcomes of long-term treatment is considered. Clinicians need to have open discussions with patients about the limitations of antidepressant research, the lack of evidence that antidepressants correct a chemical imbalance or other brain abnormality, and the range of adverse effects and mental and physical alterations they can produce.

authors

Moncrieff J

doi

10.1017/S2045796018000240

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

430-432

issue

5

eissn

2045-7960

issn

2045-7979

pii

S2045796018000240

journal_volume

27

pub_type

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