Abstract：
:Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Tegeder Idoi
10.3390/ijms17020230subject
Has Abstractpub_date
2016-02-10 00:00:00pages
230issue
2issn
1422-0067pii
ijms17020230journal_volume
17pub_type
杂志文章,评审abstract：:This study evaluates the pre-treatment of cellulose from kenaf plant to yield sugar precursors for the production of ethanol or butanol for use as biofuel additives. In order to convert the crystalline cellulosic form to the amorphous form that can undergo enzymatic hydrolysis of the glycosidic bond to yield sugars, k...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12031451
更新日期：2011-01-01 00:00:00
abstract：:Heat stress (HS) is an important factor for the survival of the marine organism Apostichopus japonicus. Lysine acetylation is a pivotal post-translational modification that modulates diverse physiological processes including heat shock response (HSR). In this study, 4028 lysine acetylation sites in 1439 proteins were ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184423
更新日期：2019-09-09 00:00:00
abstract：:(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53 family member, p73, which has not been well studied in myeloma. (2) M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010040
更新日期：2017-12-23 00:00:00
abstract：:Systemic sclerosis is an auto-immune disease characterized by skin involvement that often affects multiple organ systems. Pulmonary hypertension is a common finding that can significantly impact prognosis. Molecular pathophysiological mechanisms underlying pulmonary hypertension in systemic sclerosis can be extremely ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124430
更新日期：2020-06-22 00:00:00
abstract：:The adverse prognosis of most patients with ovarian cancer is related to recurrent disease caused by resistance to chemotherapeutic and targeted therapeutics. Besides their direct activity against tumor cells, monoclonal antibodies and tyrosine kinase inhibitors (TKIs) also influence the antitumoral activity of immune...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194693
更新日期：2019-09-22 00:00:00
abstract：:Diabetic cardiomyopathy (DCM) has emerged as a relevant cause of heart failure among the diabetic population. Defined as a cardiac dysfunction that develops in diabetic patients independently of other major cardiovascular risks factors, such as high blood pressure and coronary artery disease, the underlying cause of D...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112833
更新日期：2019-06-11 00:00:00
abstract：:Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176392
更新日期：2020-09-02 00:00:00
abstract：:Maresin-1 (MaR1) is a specialized pro-resolving mediator, derived from omega-3 fatty acids, whose functions are to decrease the pro-inflammatory and oxidative mediators, and also to stimulate cell division. We investigated the hepatoprotective actions of MaR1 in a rat model of liver ischemia-reperfusion (IR) injury. M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020540
更新日期：2020-01-15 00:00:00
abstract：:Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds. The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Six groups of r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056370
更新日期：2012-01-01 00:00:00
abstract：:Filamentous fungi possess the extraordinary ability to digest complex biomasses and mineralize numerous xenobiotics, as consequence of their aptitude to sensing the environment and regulating their intra and extra cellular proteins, producing drastic changes in proteome and secretome composition. Recent advancement in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16035803
更新日期：2015-03-12 00:00:00
abstract：:The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence. C57/BL6 female mice that were 14 ± 3 months old were infused with either Angiotensin II (AngII) or saline subcutaneously for two weeks. These mice were administered CGA of 2...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124527
更新日期：2020-06-25 00:00:00
abstract：:Induced resistance by elicitors is considered to be an eco-friendly strategy to stimulate plant defense against pathogen attack. In this study, we elucidated the effect of salicylic acid (SA) on induced resistance in rubber tree against Phytophthora palmivora and evaluated the possible defense mechanisms that were inv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071883
更新日期：2018-06-26 00:00:00
abstract：:We would like to submit the following correction to the published paper [1], the reason for this action is that the data in Table 3 were reanalyzed by one more accurate statistic method: On page 12, the sentence of paragraph three "OR and 95% CI were calculated by limited backward-LR (likelihood ratio) logistic regres...
journal_title：International journal of molecular sciences
pub_type： 已发布勘误
doi：10.3390/ijms18091899
更新日期：2017-09-04 00:00:00
abstract：:Microbes have co-evolved with human beings for millions of years. They play a very important role in maintaining the health of the host. With the advancement in next generation sequencing technology, the microbiome profiling in the host can be obtained under different circumstances. This review focuses on the current ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms161125957
更新日期：2015-11-03 00:00:00
abstract：:Ventricular arrhythmia (VA) is a major component of sudden cardiac death (SCD). To investigate the expression of brain natriuretic peptide (BNP), endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-β1) during VA, we established a rat model of VA induced by BaCl2 solution through a microinjector pump. PD142...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235845
更新日期：2019-11-21 00:00:00
abstract：:Relaxin is known to play an important role in animal pregnancies, including those of humans. It is suggested that relaxin induces aggressive cell growth and invasiveness in several types of cancer, including endometrial cancer. However, the mechanisms of relaxin remain largely unclear. In this study, we examined the e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082438
更新日期：2018-08-18 00:00:00
abstract：:S-equol is a major bacterial metabolite of the soy isoflavone daidzein. It is known to be a phytoestrogen that acts by binding to the nuclear estrogen receptors (ERs) that are expressed in various brain regions, including the cerebellum. However, the effects of S-equol on cerebellar development and function have not y...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205178
更新日期：2019-10-18 00:00:00
abstract：:Microwave-assisted depolymerization of black-liquor lignin in formic acid was studied, concentrating on the yield of liquid fractions as bio-oil 1 (mainly aromatic monomers) and bio-oil 2 (mainly aromatic oligomers) and the distribution of the specific compositions. Bio-oil 1 (9.69%) and bio-oil 2 (54.39%) achieved th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102082
更新日期：2017-10-01 00:00:00
abstract：:Metal tolerance proteins (MTPs) are plant divalent cation transporters that play important roles in plant metal tolerance and homeostasis. Poplar is an ideal candidate for the phytoremediation of heavy metals because of its numerous beneficial attributes. However, the definitive phylogeny and heavy metal transport mec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051680
更新日期：2020-02-29 00:00:00
abstract：:We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140816656
更新日期：2013-08-13 00:00:00
abstract：:Increasing evidence has shown that many chronic diseases originate from early life, even before birth, through what are termed as fetal programming effects. Glucocorticoids are frequently used prenatally to accelerate the maturation of the lungs of premature infants. High-fat diets are associated with insulin resistan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17040533
更新日期：2016-04-08 00:00:00
abstract：:Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden), known to consecutively activate PKA/PKC signaling, is cardioprotective against ischemia and reperfusion (I/R). Whether this is cardioprotective in an immature heart is unknown. Langendorff-perfused hearts from adult and immature (60 ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020494
更新日期：2018-02-07 00:00:00
abstract：:Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we searched for putative...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145028
更新日期：2020-07-16 00:00:00
abstract：:Hyperpolarization-activated calcium channels (HACCs) are found in the plasma membrane and tonoplast of many plant cell types, where they have an important role in Ca2+-dependent signalling. The unusual gating properties of HACCs in plants, i.e., activation by membrane hyperpolarization rather than depolarization, dict...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113771
更新日期：2020-05-27 00:00:00
abstract：:Sarcomere and cytoskeleton genes, or actomyosin genes, regulate cell biology including mechanical stress, cell motility, and cell division. While actomyosin genes are recurrently dysregulated in cancers, their oncogenic roles have not been examined in a lineage-specific fashion. In this report, we investigated dysregu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228690
更新日期：2020-11-18 00:00:00
abstract：:Despite recent clinical trial advances and improvements in clinical care, kidney disease due to diabetes remains the most common cause of chronic kidney failure worldwide. In the search for new treatments, recent attentions have turned to drug repurposing opportunities, including study of the histone deacetylase (HDAC...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092630
更新日期：2018-09-05 00:00:00
abstract：:Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observation...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072466
更新日期：2020-04-02 00:00:00
abstract：:While two mouse NANOS paralogues, NANOS2 and NANOS3, are crucial for maintenance of germ cells by suppression of apoptosis, the mouse NANOS1 paralogue does not seem to regulate these processes. Previously, we described a human NANOS1 p.[(Pro34Thr);(Ser83del)] mutation associated with the absence of germ cells in semin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21083009
更新日期：2020-04-24 00:00:00
abstract：:Many nutrients are absorbed via Na+ cotransport systems, and therefore it is predicted that nutrient absorption mechanisms require a large amount of luminal Na+. It is thought that Na+ diffuses back into the lumen via paracellular pathways to support Na+ cotransport absorption. However, direct experimental evidence in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020376
更新日期：2020-01-07 00:00:00
abstract：:Podocytes are visceral epithelial cells covering the outer surface of glomerular capillaries in the kidney. Blood is filtered through the slit diaphragm of podocytes to form urine. The functional and structural integrity of podocytes is essential for the normal function of the kidney. As a membrane-bound organelle, ly...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21051559
更新日期：2020-02-25 00:00:00
