Anthropogenic effects are associated with a lower persistence of marine food webs.

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the ...

journal_title：Nature communications

authors： Elias S,Morgan MA,Bikoff EK,Robertson EJ

更新日期：2017-11-20 00:00:00

abstract：:Shifting between goal-directed and habitual actions allows for efficient and flexible decision making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm, in which mice shift between goal-directed and habitual actions. We identify a role for orbitofrontal cortex (OFC) in actions following...

journal_title：Nature communications

authors： Gremel CM,Costa RM

更新日期：2013-01-01 00:00:00

abstract：:Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here,...

journal_title：Nature communications

authors： Mondo SJ,Lastovetsky OA,Gaspar ML,Schwardt NH,Barber CC,Riley R,Sun H,Grigoriev IV,Pawlowska TE

更新日期：2017-11-29 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result of non-radiative relaxation pathways, the plasmons in...

journal_title：Nature communications

authors： de Nijs B,Benz F,Barrow SJ,Sigle DO,Chikkaraddy R,Palma A,Carnegie C,Kamp M,Sundararaman R,Narang P,Scherman OA,Baumberg JJ

更新日期：2017-10-20 00:00:00

abstract：:The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocardium, independently...

journal_title：Nature communications

authors： Signore S,Sorrentino A,Borghetti G,Cannata A,Meo M,Zhou Y,Kannappan R,Pasqualini F,O'Malley H,Sundman M,Tsigkas N,Zhang E,Arranto C,Mangiaracina C,Isobe K,Sena BF,Kim J,Goichberg P,Nahrendorf M,Isom LL,Leri A,An

更新日期：2015-11-06 00:00:00

abstract：:Phosphorylation is a major post-translational mechanism of regulation that frequently targets disordered protein domains, but it remains unclear how phosphorylation modulates disordered states of proteins. Here we determine the kinetics and energetics of a disordered protein domain the kinase-inducible domain (KID) of...

journal_title：Nature communications

authors： Stanley N,Esteban-Martín S,De Fabritiis G

更新日期：2014-10-28 00:00:00

abstract：:Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. CCN1 ops...

journal_title：Nature communications

authors： Jun JI,Lau LF

更新日期：2020-03-06 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...

journal_title：Nature communications

authors： Gilfillan SMV,Györe D,Flude S,Johnson G,Bond CE,Hicks N,Lister R,Jones DG,Kremer Y,Haszeldine RS,Stuart FM

更新日期：2019-11-05 00:00:00

abstract：:Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and...

journal_title：Nature communications

authors： Chen XJ,Sun YG

更新日期：2020-06-16 00:00:00

abstract：:The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this...

journal_title：Nature communications

authors： Went M,Sud A,Försti A,Halvarsson BM,Weinhold N,Kimber S,van Duin M,Thorleifsson G,Holroyd A,Johnson DC,Li N,Orlando G,Law PJ,Ali M,Chen B,Mitchell JS,Gudbjartsson DF,Kuiper R,Stephens OW,Bertsch U,Broderick P,Ca

更新日期：2019-01-10 00:00:00

abstract：:Merons are nontrivial topological spin textures highly relevant for many phenomena in solid state physics. Despite their importance, direct observation of such vortex quasiparticles is scarce and has been limited to a few complex materials. Here, we show the emergence of merons and antimerons in recently discovered tw...

journal_title：Nature communications

authors： Augustin M,Jenkins S,Evans RFL,Novoselov KS,Santos EJG

更新日期：2021-01-08 00:00:00

abstract：:SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here,...

journal_title：Nature communications

authors： Han C,Gu Y,Shan H,Mi W,Sun J,Shi M,Zhang X,Lu X,Han F,Gong Q,Yu W

更新日期：2017-11-14 00:00:00

abstract：:Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in th...

journal_title：Nature communications

authors： Ryu JK,Petersen MA,Murray SG,Baeten KM,Meyer-Franke A,Chan JP,Vagena E,Bedard C,Machado MR,Rios Coronado PE,Prod'homme T,Charo IF,Lassmann H,Degen JL,Zamvil SS,Akassoglou K

更新日期：2015-09-10 00:00:00

abstract：:Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...

journal_title：Nature communications

authors： Apaolaza I,San José-Eneriz E,Tobalina L,Miranda E,Garate L,Agirre X,Prósper F,Planes FJ

更新日期：2017-09-06 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membrane and that subcel...

journal_title：Nature communications

authors： Shanmugasundaram K,Nayak BK,Friedrichs WE,Kaushik D,Rodriguez R,Block K

更新日期：2017-10-19 00:00:00

abstract：:BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...

journal_title：Nature communications

authors： Biswas K,Philip S,Yadav A,Martin BK,Burkett S,Singh V,Babbar A,North SL,Chang S,Sharan SK

更新日期：2018-02-07 00:00:00

abstract：:Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensi...

journal_title：Nature communications

authors： Alcântara CCJ,Landers FC,Kim S,De Marco C,Ahmed D,Nelson BJ,Pané S

更新日期：2020-11-24 00:00:00

abstract：:Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscop...

journal_title：Nature communications

authors： Atkin-Smith GK,Tixeira R,Paone S,Mathivanan S,Collins C,Liem M,Goodall KJ,Ravichandran KS,Hulett MD,Poon IK

更新日期：2015-06-15 00:00:00

abstract：:Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine cell numbers prevents invasion of endothelial cells into the dee...

journal_title：Nature communications

authors： Weiner GA,Shah SH,Angelopoulos CM,Bartakova AB,Pulido RS,Murphy A,Nudleman E,Daneman R,Goldberg JL

更新日期：2019-06-06 00:00:00

abstract：:Diatoms contribute roughly 20% of global primary production, but the factors determining their ability to adapt to global warming are unknown. Here we quantify the capacity for adaptation to warming in the marine diatom Thalassiosira pseudonana. We find that evolutionary rescue under severe (32 °C) warming is slow, bu...

journal_title：Nature communications

authors： Schaum CE,Buckling A,Smirnoff N,Studholme DJ,Yvon-Durocher G

更新日期：2018-04-30 00:00:00

abstract：:Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...

journal_title：Nature communications

authors： Li W,Kong L,Feng B,Fu H,Li H,Zeng XC,Wu K,Chen L

更新日期：2018-01-15 00:00:00

abstract：:Recent studies suggest a role for T lymphocytes in hypertension. However, whether T cells contribute to renal sodium retention and salt-sensitive hypertension is unknown. Here we demonstrate that T cells infiltrate into the kidney of salt-sensitive hypertensive animals. In particular, CD8+ T cells directly contact the...

journal_title：Nature communications

authors： Liu Y,Rafferty TM,Rhee SW,Webber JS,Song L,Ko B,Hoover RS,He B,Mu S

更新日期：2017-01-09 00:00:00

abstract：:Streptomycetes are notable for their complex life cycle and production of most clinically important antibiotics. A key factor that controls entry into development and the onset of antibiotic production is the 68-residue protein, BldC. BldC is a putative DNA-binding protein related to MerR regulators, but lacks coiled-...

journal_title：Nature communications

authors： Schumacher MA,den Hengst CD,Bush MJ,Le TBK,Tran NT,Chandra G,Zeng W,Travis B,Brennan RG,Buttner MJ

更新日期：2018-03-19 00:00:00

abstract：:Dynamic processes have many implications in functional molecules, including catalysts, enzymes, host-guest complexes, and molecular machines. Here, we demonstrate via deuterium NMR relaxation experiments how halogen bonding directly impacts the dynamics in solid 2,3,5,6-tetramethylpyrazine cocrystals, catalyzing the m...

journal_title：Nature communications

authors： Szell PMJ,Zablotny S,Bryce DL

更新日期：2019-02-22 00:00:00

abstract：:Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by constitutive deficiency of global genome nucleotide excision repair (GG-NER). The genetic mechanisms of non-skin cancers in XP-C patients remain unexplo...

journal_title：Nature communications

authors： Yurchenko AA,Padioleau I,Matkarimov BT,Soulier J,Sarasin A,Nikolaev S

更新日期：2020-11-17 00:00:00