Abstract:
:Suicide remains the 10th leading cause of death among adults in the United States (U.S.). Annually, approximately 30 per 100,000 U.S. military Veterans commit suicide, compared to 14 per 100,000 U.S. civilians. Symptoms associated with suicidality can be treatment resistant and proven-effective pharmaceuticals may have adverse side-effects. Thus, a critical need remains to identify effective approaches for building psychological resiliency in at-risk individuals. Omega-3 highly unsaturated fatty acids (n-3 HUFAs) are essential nutrients, which must be consumed in the diet. N-3 HUFAs have been demonstrated to reduce symptoms of depression, anxiety, and impulsivity - which are associated with suicide risk. Here we present the design and methods for the Better Resiliency Among Veterans and non-Veterans with Omega-3's (BRAVO) study, which is a double blind, randomized, controlled trial among individuals at risk of suicide of an n-3 HUFA versus placebo supplementation in the form of all natural fruit juice beverages. The BRAVO study seeks to determine if dietary supplementation with n-3 HUFAs reduces the risk for serious suicidal behaviors, suicidal thinking, negative emotions, and symptoms associated with suicide risk. Sub-analyses will evaluate efficacy in reducing depressive symptoms, alcohol, and nicotine use. A sub-study utilizes functional magnetic resonance imaging (fMRI) to evaluate the neuropsychological and neurophysiological effects of n-3 HUFAs. We also outline selection of appropriate proxy outcome measures for detecting response to treatment and collection of ancillary data, such as diet and substance use, that are critical for interpretation of results.
journal_name
Contemp Clin Trialsjournal_title
Contemporary clinical trialsauthors
Marriott BP,Hibbeln JR,Killeen TK,Magruder KM,Holes-Lewis K,Tolliver BK,Turner TH,BRAVO Group.doi
10.1016/j.cct.2016.02.002subject
Has Abstractpub_date
2016-03-01 00:00:00pages
325-33eissn
1551-7144issn
1559-2030pii
S1551-7144(16)30016-7journal_volume
47pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The FEVER (Frail Elderly Vibration Exercise Response) study aims to address a paucity of research focusing on the use of Whole Body Vibration (WBV) by frail elderly who, with the highest levels of dependence and fall-related hospitalisation/mortality, potentially stand to benefit most from such accessible ex...
journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,评审
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Contemporary clinical trials
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cct.2016.04.009
更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cct.2017.04.003
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cct.2013.11.013
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
doi:10.1016/j.cct.2012.08.008
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
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journal_title:Contemporary clinical trials
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pub_type: 杂志文章
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
doi:10.1016/j.cct.2007.05.002
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
doi:10.1016/j.cct.2014.11.006
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,随机对照试验
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journal_title:Contemporary clinical trials
pub_type: 杂志文章,meta分析
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
doi:10.1016/j.cct.2006.05.002
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journal_title:Contemporary clinical trials
pub_type: 杂志文章
doi:10.1016/j.cct.2012.07.006
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