Heart positive: design of a randomized controlled clinical trial of intensive lifestyle intervention, niacin and fenofibrate for HIV lipodystrophy/dyslipidemia.

abstract：:The Ready Steady 3.0 trial is designed to test the main and interactive effects of two behavior change intervention components, within an 8-week physical activity intervention, on older adults' physical activity (PA). Each component is comprised of behavior change strategies that emphasize two different evidence-based...

journal_title：Contemporary clinical trials

authors： McMahon SK,Lewis BA,Guan W,Wyman JF,Rothman AJ

更新日期：2020-12-05 00:00:00

abstract：UNLABELLED:Latinos bear a disproportionate burden of the dual pandemic of obesity and diabetes. However, successful interventions addressing this disparity through primary care are lacking. To address this gap, the 5-year Vida Sana (Healthy Life) study tests a culturally adapted and technology-enhanced group-based Diab...

journal_title：Contemporary clinical trials

authors： Rosas LG,Lv N,Xiao L,Lewis MA,Zavella P,Kramer MK,Luna V,Ma J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Obesity, a disorder associated with a myriad of comorbidities, is increasing at an alarming rate around the world. Given that pharmacotherapy has limited available options and that bariatric surgery is reserved for those who are morbidly obese or who have significant comorbidities, the most common approach t...

journal_title：Contemporary clinical trials

authors： Burke LE,Choo J,Music E,Warziski M,Styn MA,Kim Y,Sevick MA

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:African American (AA) women perform low levels of physical activity (PA) and are disproportionally burdened by cardiometabolic disease conditions when compared to White women and the U.S. population as a whole. These disparities emphasize the need for innovative and effective interventions to increase PA and...

journal_title：Contemporary clinical trials

authors： Joseph RP,Ainsworth BE,Vega-López S,Adams MA,Hollingshead K,Hooker SP,Todd M,Gaesser GA,Keller C

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Basic research suggests that rapid increases in circulating inflammatory and hemostatic blood markers may trigger or indicate impending plaque rupture and coronary thrombosis, resulting in acute ischemic heart disease (IHD) events. However, these associations are not established in humans. METHODS AND RESUL...

journal_title：Contemporary clinical trials

authors： McDermott MM,Greenland P,Liu K,Tian L,Green D,Shah SJ,Huffman M,Wilkins J,Kibbe M,Liao Y,Huang CC,Skelly C,Jacobs C,McCarthy W,Auerbach A,Lloyd-Jones D

更新日期：2014-05-01 00:00:00

abstract：:Whole exome and whole genome sequencing are applications of next generation sequencing transforming clinical care, but there is little evidence whether these tests improve patient outcomes or if they are cost effective compared to current standard of care. These gaps in knowledge can be addressed by comparative effect...

journal_title：Contemporary clinical trials

authors： Gallego CJ,Bennette CS,Heagerty P,Comstock B,Horike-Pyne M,Hisama F,Amendola LM,Bennett RL,Dorschner MO,Tarczy-Hornoch P,Grady WM,Fullerton SM,Trinidad SB,Regier DA,Nickerson DA,Burke W,Patrick DL,Jarvik GP,Veenstra D

更新日期：2014-09-01 00:00:00

abstract：:Although progress has been made to elucidate the effects of exercise as a strategy for reducing obesity and related cardiometabolic risk factors, the specific exercise exposures required to achieve optimal benefit continue to be the source of considerable uncertainty and debate. Despite the inference of a dose-depende...

journal_title：Contemporary clinical trials

authors： Ross R,Hudson R,Day AG,Lam M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend behavioral intervention to achieve a modest weight loss (e.g., 3-5%) as a first-line obesity treatment. Online behavioral obesity treatment, delivered via the Rx Weight Loss (RxWL) program, produces clinically significant initial weight losses. However, the program's pragmatic ut...

journal_title：Contemporary clinical trials

authors： Espel-Huynh HM,Wing RR,Goldstein CM,Thomas JG

更新日期：2019-07-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a highly prevalent condition in aging men, which can be progressive and lead to acute urinary retention (AUR) and the need for surgery. It is commonly treated with alpha-blockers and 5alpha-reductase inhibitors (5ARIs), both of which improve the symptoms of BPH. Long-term treatmen...

journal_title：Contemporary clinical trials

authors： Siami P,Roehrborn CG,Barkin J,Damiao R,Wyczolkowski M,Duggan A,Major-Walker K,Morrill BB,CombAT study group.

更新日期：2007-11-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization ...

journal_title：Contemporary clinical trials

authors： Chevret S,Verlhac S,Ducros-Miralles E,Dalle JH,de Latour RP,de Montalembert M,Benkerrou M,Pondarré C,Thuret I,Guitton C,Lesprit E,Etienne-Julan M,Elana G,Vannier JP,Lutz P,Neven B,Galambrun C,Paillard C,Runel C,Jube

更新日期：2017-11-01 00:00:00

abstract：:This randomized, controlled trial tested the effectiveness of a nurse-run, telephone-based intervention to improve lipid control in patients with diabetes. Our patient population is predominantly low-income and Latino. Using our diabetes registry, we randomly assigned 381 patients to continue with their usual care and...

journal_title：Contemporary clinical trials

authors： Fischer H,Mackenzie T,McCullen K,Everhart R,Estacio RO

更新日期：2008-09-01 00:00:00

abstract：:Identifying effective strategies for treating obesity is a clinical challenge and a public health priority. The present study is an innovative test of the relative effectiveness of lottery-based financial incentives and environmental strategies on weight loss and maintenance. The Healthy Weigh study is evaluating the ...

journal_title：Contemporary clinical trials

authors： Glanz K,Shaw PA,Hoffer K,Chung A,Zhu J,Wu R,Huang QE,Choi JR,Volpp KG

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Unlike conventional time-to-event analysis of composite endpoints in clinical trials, the "win ratio" method allows for flexibility in prioritizing their components. Here, we compare the EVOLVE trial findings using the win ratio with those from time-to-event analysis. METHODS: EXPOSURE:Randomization to cin...

journal_title：Contemporary clinical trials

authors： Abdalla S,Montez-Rath ME,Parfrey PS,Chertow GM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:In the past 20-30 years, the prevalence of atopic diseases, particularly among children in the Western world, has increased. It has been suggested that Western lifestyle may have reduced the overall exposure to microbial stimulation early in life. The role of the gut flora in this connection has been studied...

journal_title：Contemporary clinical trials

authors： Øien T,Storrø O,Johnsen R

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims to provide high-level evidence on the comparative effectiveness and cost-effectiveness of repeat rubber band ligation (RBL) versus sutured muc...

journal_title：Contemporary clinical trials

authors： Kuiper SZ,Dirksen CD,Kimman ML,Van Kuijk SMJ,Van Tol RR,Muris JWM,Watson AJM,Maessen JMC,Melenhorst J,Breukink SO,Napoleon Trial Study Group.

更新日期：2020-12-01 00:00:00

abstract：:Thirty percent of all military personnel smoke cigarettes. Because of the negative health consequences and their impact on physical fitness, overall health, and military readiness, the Department of Defense has identified the reduction of tobacco use as a priority of US military forces. This study aims to evaluate the...

journal_title：Contemporary clinical trials

authors： Richey PA,Klesges RC,Talcott GW,Debon M,Womack C,Thomas F,Hryshko-Mullen A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Many studies on the health effects of the glycemic index (GI) are confounded by differences in the intakes of other macronutrients and fibre. Little data exist about the within- and between-subject variability of the GI. OBJECTIVE:Our objectives were therefore (i) to calculate the GI of eight commonly used ...

journal_title：Contemporary clinical trials

authors： Vrolix R,Mensink RP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic stea...

journal_title：Contemporary clinical trials

authors： Kessoku T,Imajo K,Kobayashi T,Honda Y,Kato T,Ogawa Y,Tomeno W,Kato S,Higurashi T,Yoneda M,Kirikoshi H,Kubota K,Taguri M,Yamanaka T,Usuda H,Wada K,Saito S,Nakajima A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:In 2007, we commenced the Healthy Beginnings Trial (HBT) Phase 1 study, which is the first randomised controlled trial (RCT) to test the effectiveness of an early childhood obesity intervention in children aged up to 2 years. The results were promising with significant improvements in infant feeding practice...

journal_title：Contemporary clinical trials

authors： Wen LM,Baur LA,Rissel C,Flood V,Simpson JM,Hayes A,Hardy LL,Wardle K

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Although people who inject drugs (PWID) having the highest incidence and prevalence of hepatitis C virus (HCV) in the US, HCV treatment is rarely provided to PWID due to assumptions about poor adherence and reinfection risk. As direct-acting antiviral agents (DAAs) have achieved sustained virologic response ...

journal_title：Contemporary clinical trials

authors： Litwin AH,Jost J,Wagner K,Heo M,Karasz A,Feinberg J,Kim AY,Lum PJ,Mehta SH,Taylor LE,Tsui JI,Pericot-Valverde I,Page K,HERO Study Group.

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Formation of diet and physical activity habits begins during early childhood. However, many preschool-aged children in the United States do not achieve recommendations for a nutritious diet or active lifestyle. Two important spheres of influence, home and child care, could ensure that children receive consis...

journal_title：Contemporary clinical trials

authors： Hennink-Kaminski H,Vaughn AE,Hales D,Moore RH,Luecking CT,Ward DS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) increases the risk of thromboembolic stroke. An oral anticoagulant should be administrated to prevent stroke in patients with moderate stroke risk (ie, CHA2DS2-VASc score>2). If the stroke risk is low (i.e. the score=1), however, antiplatelet agent such as aspirin is widely used. Asp...

journal_title：Contemporary clinical trials

authors： Park SM,Jeong H,Jung MH,Hong KS,Hong MK,Bang CS,Kim CY

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:In a recent publication, the International Guidelines for Groin Hernia Management by the European Hernia Society (EHS) recognized the need to individualize and tailor the surgical approach for hernia repair. There may be different opportunities for optimization of the surgical technique for surgeons performi...

journal_title：Contemporary clinical trials

authors： LeBlanc KA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Extant obesity efforts have had a limited impact among low-income underserved children, in part because existing programs are limited in terms of their short duration and low dosage, limited accessibility and sustainability; and failure to address barriers faced by diverse low-income families. METHODS:This ...

journal_title：Contemporary clinical trials

authors： de la Haye K,Fluke M,Laney PC,Goran M,Galama T,Chou CP,Salvy SJ

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Bipolar Disorder (BD) is a common and severe form of mental illness. Pharmacotherapy is the main treatment offered, but has limited effectiveness, and there is increasing evidence that people with BD respond well to psychological interventions. Inequalities in access to face-to-face psychological interventio...

journal_title：Contemporary clinical trials

authors： Todd NJ,Solis-Trapala I,Jones SH,Lobban FA

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:New approaches are needed to better monitor blood pressure (BP) between physician visits, especially for patients in rural areas or for those who lack transportation. We have developed a custom-built bi-directional texting platform for home BP measurements that can then be managed by clinical pharmacists loc...

journal_title：Contemporary clinical trials

authors： Polgreen LA,Carter BL,Polgreen PM,Snyder PM,Sewell DK,Bayman EO,Francis SL,Simmering JE,Parker C,Finkelstein R

更新日期：2020-11-01 00:00:00

abstract：:Lumbar spinal stenosis is a common degenerative disorder of the spine in elderly patients that can be effectively treated with decompression surgery in some patients. Radiological findings in the diagnostic work-up of the patients do not always correlate well with clinical symptoms, and guidance about when to proceed ...

journal_title：Contemporary clinical trials

authors： Staub LP,Barz T,Melloh M,Lord SJ,Chatfield M,Bossuyt PM

更新日期：2011-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a leading cause of chronic liver disease. The natural history of HCV infection is heterogeneous, and a person infected with HCV can clear the virus or progress to a chronic infection. The chronic infection can remain asymptomatic for decades before the development of liver cirrhosis and/or c...

journal_title：Contemporary clinical trials

authors： Kang M,Nicolay U

更新日期：2008-09-01 00:00:00