Abstract:
PURPOSE:To compare multiparametric magnetic resonance imaging (mpMRI) with transrectal ultrasound-guided prostate biopsy (TRUS-bx) for the diagnosis and monitoring of small-volume prostate cancer (PCa) in patients on active surveillance (AS). METHODS:In a retrospective cross-sectional validation study, 100 patients on AS for PCa underwent a systematic 12-core TRUS-bx (the gold standard) as well as mpMRI, on either a 1.5 or 3 Tesla scanner (32 and 68 patients, respectively). Three pathologists reported biopsy histology separately. A single, experienced radiologist scored mpMRI scans using the PI-RADS system. We compared left- and right-sided PI-RADS scores of the peripheral zone with TRUS-bx results of the relevant prostate lobe. We then estimated the specificity and sensitivity of mpMRI in diagnosing low-grade low-risk PCa in our AS cohort. RESULTS:The sensitivity of mpMRI was 37% (95% CI 28-47%) and specificity was 85% (CI 76-92%) for cancer. The negative predictive value was 51% (CI 44-60%), and the positive predictive value was 76% (CI 62-87%). The positive and negative likelihood ratios were 2.5 and 0.7, respectively. CONCLUSION:Because of its low specificity and low negative predictive value, mpMRI is not suitable for diagnosing low-grade small-volume PCa. However, because of a specificity of 85% and a negative likelihood ratio of 0.7, mpMRI may be useful for follow-up of previously TRUS-bx diagnosed patients who are on AS.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Sahibzada I,Batura D,Hellawell Gdoi
10.1007/s11255-016-1212-4subject
Has Abstractpub_date
2016-04-01 00:00:00pages
529-33issue
4eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1212-4journal_volume
48pub_type
杂志文章abstract:OBJECTIVES:To prospectively compare biopsy outcomes between free-hand transperineal mpMRI/TRUS fusion targeted biopsy (TB) and transperineal systematic biopsy (SB) in patients with first prostate biopsy. PATIENTS AND METHODS:In all, 224 consecutive patients with the suspicion of PCa were investigated. All patients wer...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1484-8
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Bladder neck contracture (BNC) following prostatectomy has been reported in 0.5-32% of cases. While the etiology of a BNC is unclear, several factors have been associated with this complication, including blood loss, devascularization of bladder neck tissue, poor mucosal apposition and urinary extravasation....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9239-1
更新日期:2008-01-01 00:00:00
abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081940
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS:Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1857-2
更新日期:2018-07-01 00:00:00
abstract::In this study, we evaluated low dose intravesical bacillus Calmette-Guerin (BCG) therapy following transurethral resection (TUR) in 80 patients with superficial bladder cancer. The patients were divided into two groups. Of the Connaught BCG strain 81 mg was given to 40 patients in Group 1 and 54 mg to the remainder of...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02550276
更新日期:1998-01-01 00:00:00
abstract::Penile cancer is an uncommon disease in the industrialized world that most frequently presents at low stage and is cured with treatment of local and regional surgery. In cases of advanced cancer, the use of more aggressive surgical techniques and the addition of adjuvant therapy may be warranted. So far, few agents ha...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-011-0011-1
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:We compared the accuracy of magnetic resonance (MR) urethrography and X-ray urethrography with operative findings for urethral strictures and observed their effects on treatment. MATERIALS AND METHODS:A total of 87 male patients (10-85 years of age) treated from January 2015 to December 2016 were included in t...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02162-w
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearanc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9496-7
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Vesicoureteral reflux (VUR) is the most common congenital urinary tract abnormality in children. The objective of this study was to evaluate the diagnostic value of urine neutrophil gelatinase-associated lipocalin (NGAL) in children with primary vesicoureteral reflux (VUR). MATERIALS AND METHODS:A total of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02355-3
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The age-related decline of the testosterone-to-estrogen (T-to-E2) ratio in serum is associated with the increased prevalence of prostatic inflammation. The goal of the study was to induce prostatic inflammation with E2 and androgen treatment and to explore the inflammatory markers and apoptosis on prostatitis. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0845-4
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The reported association between individual indicators of socioeconomic status (SES) and mortality in dialysis patients was inconsistent in previous studies. We performed a meta-analysis to identify the association between SES and mortality of dialysis population. METHODS:The meta-analysis was conducted in ...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02078-5
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To analyze indications, surgical technique, complications and long-term outcomes of kidney autotransplantation (KAT) after 26-year experience at a single institution. MATERIALS AND METHODS:A retrospective observational study of patients who underwent KAT at our institution (January 1990-December 2016) was ca...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-017-1680-1
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:We aimed to evaluate the efficacy of Lachance formula and more readily available clinical or laboratory factors (other than serum methanol level) in prediction of the needed time for hemodialysis in methanol-poisoned patients. METHODS:In a retrospective study, all methanol-poisoned patients referred to us betw...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1521-2
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:The 276G>T polymorphism of the adiponectin (ADIPOQ) gene has been correlated with plasma adiponectin, type 2 diabetes (T2D) and its complications. Studies of the role of 276G>T polymorphism in the prevalence of T2D kidney disease are few and contradictory; ethnic differences might play a role. We aimed to asses...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0118-4
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. METHODS:Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention g...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02423-z
更新日期:2020-07-01 00:00:00
abstract:UNLABELLED:We examined renal function and urinary drainage of children with primary megaureter (PMU) in dependence on conservative or operative treatment. MATERIAL AND METHODS:The retrospective analysis covering the years 1994 to 2000 comprised children at an age of 0-7 years with 35 PMU. Sonography, dynamic MAG3 reno...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3615-5
更新日期:2006-01-01 00:00:00
abstract::Serum concentrations of luteinizing hormone (LH), testosterone, prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) were measured in 16 patients with advanced prostatic cancer before and after treatment with luteinizing hormone-releasing hormone (LHRH) analogue. An initial rise of serum LH and testos...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564863
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To evaluate the possible association between metabolic syndrome (MetS) and infectious complications after prostate biopsy. METHODS:A total of 480 men underwent prostatic biopsy due to elevated prostate-specific antigen levels and/or abnormal digital rectal examination. Patients were divided into two subgroups ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0904-x
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:We aimed to describe our experience in administering an innovative surgical technique to treat pediatric cases of exstrophy-epispadias complex. MATERIAL AND METHODS:Between 1995 and 2004, seven consecutive patients (six males) with exstrophy-epispadias complex were treated using ileocecal segment for bladder...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9143-0
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The numbers of older people on haemodialysis is rising. As aging and renal failure are risk factors for autonomic failure and haemodialysis involves significant fluid shifts we hypothesized that older patients would be susceptible to hypotensive events between dialysis sessions. Postural hypotension is a ris...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000022866.07751.4a
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:We sought to evaluate the effects of oral testosterone undecanoate treatment based on the temporary growth of penis and the complications of surgery in children with microphallic hypospadias. MATERIALS AND METHODS:A total of 72 randomized consecutive children with microphallic hypospadias were included in the ...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-015-0972-6
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Peritoneal dialysis (PD) related infections are associated with technique failure and mortality. The aim of this multicentre study was to examine epidemiology, treatment and outcomes of PD-related infections in Poland as well as practice patterns for prevention of these complications in the context of curren...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-2057-9
更新日期:2019-02-01 00:00:00
abstract::We report a boy with urachal cyst managed laparoscopically. A 9-year-old boy was referred from another hospital with a history of low abdominal pain. We laparoscopically excised the urachal cyst, removing all structures within the umbilicovesical fascia, including the urachus and each medial umbilical ligament, as wel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9132-3
更新日期:2007-01-01 00:00:00
abstract::Evaluation of potential candidates for testosterone replacement therapy (TRT) includes a complete medical history, physical examination, and hormonal screening. The choice of testosterone assay is important in clinical decision making. TRT should, in theory, approximate natural endogenous production of the hormone. Th...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-010-9879-4
更新日期:2012-02-01 00:00:00
abstract::Deoxyribonuclease (DNase) activity and metal ion concentrations in lymphocytes of patients with chronic renal failure and in healthy controls were studied. The data suggest that T and B lymphocyte nuclei of patients with renal failure show increased DNase activity when compared to their healthy counterparts. It is sug...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552124
更新日期:1992-01-01 00:00:00
abstract::Among 104 patients with urethral strictures treated over a period of 3 years, sixty-five (63%) had complications such as inflammatory periurethral mass, watering-can perineum with discharging sinuses and fistulas, associated urethral calculi, periurethral abscesses and urethral diverticula. Seventy-four per cent of th...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549587
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:The present study aimed to evaluate the impact of a filmed research-based drama-Fit for Dialysis-and an exercise program on patients' physical activity and fitness outcomes. METHODS:Nineteen (10 at the intervention site, 9 at the control site) older patients with a medical diagnosis of hemodialysis-dependent e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02745-y
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. METHODS:SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-rea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0233-x
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC ass...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1821-1
更新日期:2018-05-01 00:00:00
abstract::We report a case of renal cell carcinoma with solitary metastasis to the bladder which occurred and was treated synchronously. The mode of spread and possible treatment modalities are discussed with relevant information from the literature. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02767654
更新日期:1994-01-01 00:00:00