Abstract：
:Biological hydrogels, e.g. bacterial cellulose (BC) hydrogel, attracted increasing interest in recent decades since they show a good potential for biomedical engineering as replacements of real tissues thanks mainly to their good biocompatibility and fibrous structure. To select potential candidates for such applications, a comprehensive understanding of their performance under application-relevant conditions is needed. Most hydrogels demonstrate time-dependent behaviour due to the contribution of their liquid phase and reorientation of fibres in a process of their deformation. To quantify such time-dependent behaviour is crucial due to their exposure to complicated loading conditions in body environment. Some hydrogel-based biomaterials with a multi-layered fibrous structure demonstrate a promise as artificial skin and blood vessels. To characterise and model time-dependent behaviour of these multi-layered hydrogels along their through-thickness direction is thereby of vital importance. Hence, a holistic study combining mechanical testing and micro-morphological observations of BC hydrogel with analytical modelling of its relaxation behaviour based on fraction-exponential operators was performed. The results show a good potential to use a fraction-exponential model to describe such behaviour of multi-layered hydrogels, especially at stages of stress decay at low forces and of stress equilibrium at high forces.
journal_name
J Mech Behav Biomed Materauthors
Gao X,Kuśmierczyk P,Shi Z,Liu C,Yang G,Sevostianov I,Silberschmidt VVdoi
10.1016/j.jmbbm.2015.12.021subject
Has Abstractpub_date
2016-06-01 00:00:00pages
90-98eissn
1751-6161issn
1878-0180pii
S1751-6161(15)00495-6journal_volume
59pub_type
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