Some mammalian retinae lack FMRF-amide-like immunoreactive efferents.

abstract：:The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Müller cells, offering conclusive evidence that in the mammalian retina, the protein is confine...

journal_title：Investigative ophthalmology & visual science

authors： Cocchia D,Polak JM,Terenghi G,Battaglia F,Stolfi V,Gangitano C,Michetti F

更新日期：1983-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether clinical signs of infectious keratitis can be used to identify the causative organism. METHODS:Eighty photographs of eyes with culture-proven bacterial keratitis or smear-proven fungal keratitis were randomly selected from 2 clinical trials. Fifteen cornea spe...

journal_title：Investigative ophthalmology & visual science

authors： Dalmon C,Porco TC,Lietman TM,Prajna NV,Prajna L,Das MR,Kumar JA,Mascarenhas J,Margolis TP,Whitcher JP,Jeng BH,Keenan JD,Chan MF,McLeod SD,Acharya NR

更新日期：2012-04-02 00:00:00

abstract：PURPOSE:Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of neovascular AMD; however, risk attributable to genetic variation within pathway genes is unclear. We s...

journal_title：Investigative ophthalmology & visual science

authors： Owen LA,Morrison MA,Ahn J,Woo SJ,Sato H,Robinson R,Morgan DJ,Zacharaki F,Simeonova M,Uehara H,Chakravarthy U,Hogg RE,Ambati BK,Kotoula M,Baehr W,Haider NB,Silvestri G,Miller JW,Tsironi EE,Farrer LA,Kim IK,Park K

更新日期：2014-05-08 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:One of the critical difficulties in design of a high-resolution retinal implant is the proximity of stimulating electrodes to the target cells. This is a report of a phenomenon of retinal cellular migration into a perforated membrane that may help to address this problem. METHODS:Mylar membranes with an array ...

journal_title：Investigative ophthalmology & visual science

authors： Palanker D,Huie P,Vankov A,Aramant R,Seiler M,Fishman H,Marmor M,Blumenkranz M

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the presence and extent of hypoxia in murine retinoblastoma tumors and the feasibility of targeting hypoxic cells as a novel therapeutic strategy. METHODS:Hypoxic and vascular areas in LH(BETA)T(AG) mouse retinal tumors were measured using immunohistochemistry. The gly...

journal_title：Investigative ophthalmology & visual science

authors： Boutrid H,Jockovich ME,Murray TG,Piña Y,Feuer WJ,Lampidis TJ,Cebulla CM

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To compare the clinical outcomes of aberration-free ablation profiles based on the normal corneal vertex (CV) and the pupil center (PC) in relation to laser in situ keratomileusis. Aberration-free aspheric ablation treatments were performed in all cases. METHODS:Two myopic astigmatism groups (CV centered using...

journal_title：Investigative ophthalmology & visual science

authors： Arbelaez MC,Vidal C,Arba-Mosquera S

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To determine whether vascular tone of isolated porcine retinal veins can be modulated by tissue-generated vasoactive factors such as endothelin-1 and adenosine. Such information may be useful in understanding the role of the retinal veins in regulating blood flow, and also provide a model for investigating new ...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Su EN,Cringle SJ,Morgan WH,McAllister IL,Yu PK

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Erythropoietin (EPO) modulates erythropoiesis by inhibiting apoptosis in erythrocyte progenitors. Recently, EPO has been shown to be protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial. However, little is known about EPO sign...

journal_title：Investigative ophthalmology & visual science

authors： Weishaupt JH,Rohde G,Pölking E,Siren AL,Ehrenreich H,Bähr M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To evaluate the ocular complications of intravitreal injection of high dose bevacizumab in monkey eyes. METHODS:Four healthy monkeys (Macaca fuscata) received an intravitreal injection of either 6.25 or 12.5 mg bevacizumab in the right eye; the left control eye received an intravitreal injection of the same vo...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai K,Akiyama H,Shimoda Y,Yoshida I,Kurabayashi M,Kishi S

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Defensins are naturally occurring antimicrobial peptides. Recently the authors published evidence of defensin production by the human ocular surface. A study was undertaken to look for intraocular defensins that may account for unexplained antimicrobial activity of intraocular fluids. METHODS:Reverse transcrip...

journal_title：Investigative ophthalmology & visual science

authors： Haynes RJ,McElveen JE,Dua HS,Tighe PJ,Liversidge J

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation. METHODS:Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical ana...

journal_title：Investigative ophthalmology & visual science

authors： Ogawa Y,Kuwana M,Yamazaki K,Mashima Y,Yamada M,Mori T,Okamoto S,Oguchi Y,Kawakami Y

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：:Corneas of fetal and young albino rabbits were examined by light and transmission electron microscopy. In addition, DNA and hydroxyproline content were measured in developing stroma. The results were compared with similar data from healing corneas in adult rabbits and from developing corneas of other animal species. I...

journal_title：Investigative ophthalmology & visual science

authors： Cintron C,Covington H,Kublin CL

更新日期：1983-05-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To provide a clinical and genetic description of a patient cohort with Stargardt disease (STGD1) with identifiable foveal sparing. METHODS:Patients with retinal atrophy (defined as an absence of autofluorescence) that surrounded the fovea by at least 180° and did not include the fovea were defined as having fo...

journal_title：Investigative ophthalmology & visual science

authors： van Huet RA,Bax NM,Westeneng-Van Haaften SC,Muhamad M,Zonneveld-Vrieling MN,Hoefsloot LH,Cremers FP,Boon CJ,Klevering BJ,Hoyng CB

更新日期：2014-10-16 00:00:00

abstract：:The purpose of this study was to determine whether unilateral gonadectomy caused any change in intraocular pressure. Repeated measurements in 22 male and nine female rabbits after unilateral gonadectomy were made by three different methods of determining intraocular pressure. We were unable to find a decrease in intra...

journal_title：Investigative ophthalmology & visual science

authors： van den Pol A,Maul E,Sears M

更新日期：1977-03-01 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. METHODS:The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) prolife...

journal_title：Investigative ophthalmology & visual science

authors： Hos D,Regenfuss B,Bock F,Onderka J,Cursiefen C

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To evaluate diurnal intraocular pressure (DIOP) among individuals with primary angle closure (PAC) or primary angle-closure suspect (PACS). Additionally, the hypothesis that greater DIOP fluctuation is related to smaller angle parameters was investigated. METHODS:Forty Caucasian newly referred untreated patien...

journal_title：Investigative ophthalmology & visual science

authors： Sanchez-Parra L,Pardhan S,Buckley RJ,Parker M,Bourne RR

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra; Pfizer, New York, NY), a selective phosphodiesterase type-5 (PDE5) inhibitor, is widely used to treat impotence by improving penile blood flow via elevation of cGMP. However, its effect on ocular circulation is controversial and whether retinal arterioles are responsive to this drug remains ...

journal_title：Investigative ophthalmology & visual science

authors： Yuan Z,Hein TW,Rosa RH Jr,Kuo L

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:To describe the normal physiological relationship between retinal arteriolar and venular caliber and retinal nerve fiber layer (RNFL), macular, and optic nerve head parameters. METHODS:The Sydney Childhood Eye Study assessed 2038 adolescents aged 12 years. Retinal vessel calibers were measured from digital fun...

journal_title：Investigative ophthalmology & visual science

authors： Samarawickrama C,Huynh SC,Wang JJ,Pai A,Joachim N,Burlutsky G,Wong TY,Mitchell P

更新日期：2009-12-01 00:00:00

abstract：Purpose:To determine the long-term safety and efficacy of WST-D/near-infrared (NIR) corneal stiffening. Methods:One eye of 23 New Zealand White rabbits was de-epithelialized mechanically followed by topical application of 2.5 mg/mL WST11, combined with dextran-500 (WST-D) for 20 minutes. Subsequently, samples were irr...

journal_title：Investigative ophthalmology & visual science

authors： Brekelmans J,Goz A,Dickman MM,Brandis A,Sui X,Wagner HD,Nuijts RMMA,Scherz A,Marcovich AL

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To assess visual acuity recovery times and cone photopigment regeneration kinetics after a bleach in the fovea of patients with dominant retinitis pigmentosa due to rhodopsin mutations. METHODS:The authors measured acuity recovery times by computerized photostress testing in 13 patients with dominant retinitis...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Pawlyk BS,Berson EL

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To investigate the protective effects of cobalt protoporphyrin (CoPP), a potent heme oxygenase (HO)-1 inducer, in a rat model of ischemia-reperfusion injury and to document the possible antiapoptotic and anti-inflammatory mechanisms underlying the protection. METHODS:Rats pretreated with intraperitoneal inject...

journal_title：Investigative ophthalmology & visual science

authors： Sun MH,Pang JH,Chen SL,Han WH,Ho TC,Chen KJ,Kao LY,Lin KK,Tsao YP

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. METHODS:Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RP...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Ishikawa K,Spee C,Mehta HH,Wan J,Yen K,Cohen P,Kannan R,Hinton DR

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS:Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. ...

journal_title：Investigative ophthalmology & visual science

authors： Kwong JM,Quan A,Kyung H,Piri N,Caprioli J

更新日期：2011-12-28 00:00:00

abstract：:The earlier reports from this laboratory that the renewal of rat photoreceptor membranes was dependent on essential fatty acids have not been confirmed in more recent studies. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RE

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00