Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials.


:Previous clinical studies have reported mixed results regarding the effect of probiotics on lipid metabolism. Therefore, we conducted a meta-analysis of randomized controlled trials to quantify the direction and magnitude of the potential effect of probiotics on blood lipid concentrations.Eligible studies were randomized, placebo-controlled trials whose interventions were probiotic products containing live bacteria. The studies reported net changes in lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) and their associated standard deviations (or the data to calculate them). The probiotic products did not contain prebiotics or other active ingredients, and the full article was accessible in English.The pooled mean net change in lipid profiles and 95% confidence intervals (95% CIs) were calculated. Q statistics and I were calculated to examine heterogeneity. Potential sources of heterogeneity were investigated via subgroup and sensitivity analyses, and publication biases were estimated.A total of 30 randomized controlled trials with 1624 participants (828 in intervention groups and 796 in placebo groups) were included in this analysis. Subjects treated with probiotics demonstrated reduced total cholesterol and LDL cholesterol compared to control subjects by 7.8 mg/dL (95% CI: -10.4, -5.2) and 7.3 mg/dL (95% CI: -10.1, -4.4), respectively. There was no significant effect of probiotics on HDL cholesterol or triglycerides. The effect of probiotics on total cholesterol and LDL cholesterol depended on a variety of factors. The significant effects were greater for higher baseline total cholesterol levels, longer treatment durations, and certain probiotic strains. In addition, these associations seem stronger in studies supported by probiotics companies.The studies included in this meta-analysis showed significant heterogeneity as indicated by the Q statistics and I. In addition, industry sponsorship may affect study findings.These results suggest that the use of probiotics may improve lipid metabolism by decreasing total and LDL cholesterol concentrations. However, both the efficacy of probiotics for cholesterol lowering and safety should be investigated further in well-designed clinical trials.


Medicine (Baltimore)




Cho YA,Kim J




Has Abstract


2015-10-01 00:00:00
















  • Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report.

    abstract:INTRODUCTION:Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management usi...


    pub_type: 杂志文章


    authors: Lai H,Wang K,Dong Q,Zhu X,Li X,Qi S

    更新日期:2019-04-01 00:00:00

  • Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis.

    abstract::This study aims to analyze the characteristics of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for cerebral alveolar echinococcosis (CAE).Twenty-five CAE patients underwent F-FDG PET/CT, and the diagnosis was confirmed by clinical and surgical pathology. The F-FDG PET/CT results...


    pub_type: 杂志文章


    authors: Yibulayin A,Li XH,Qin YD,Jia XY,Zhang QZ,Li YB

    更新日期:2018-09-01 00:00:00

  • Application of siemens SMART neuro attenuation correction in brain PET imaging.

    abstract::Siemens SMART neuro attenuation correction (SNAC) is a new type of calculated attenuation correction (CAC) method. This article aimed to evaluate the effect of SNAC on the quantitative analysis of brain positron emission tomography (PET) imaging.Brain PET images of 52 healthy participants after reconstructed by SNAC a...


    pub_type: 杂志文章


    authors: Shao X,Xu M,Qiu C,Niu R,Wang Y,Wang X

    更新日期:2018-09-01 00:00:00

  • The effectiveness and safety of extracorporeal shock wave lithotripsy for the management of kidney stones: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:Extracorporeal shockwave lithotripsy (ESWL) has gained worldwide popularity as one of the most commonly used minimally invasive management of urinary tract stones. The objective of this study was to evaluate the efficacy and safety of ESWL for patients with kidney stones (KS). MATERIALS AND METHODS:This pro...


    pub_type: 杂志文章


    authors: Cao L,Wang YQ,Yu T,Sun Y,He J,Zhong Y,Li X,Sun X

    更新日期:2020-09-18 00:00:00

  • Comparison of the cuff pressure of a TaperGuard endotracheal tube and a cylindrical endotracheal tube after lateral rotation of head during middle ear surgery: A single-blind, randomized clinical consort study.

    abstract:BACKGROUND:Positional change affects the cuff pressure of an endotracheal tube (ETT) in treacheally intubated patients. We compared the cuff pressure of a TaperGuard ETT and a cylindrical ETT after lateral rotation of head during middle ear surgery. METHODS:Fifty-two patients aged 18-70 years underwent a tympanomastoi...


    pub_type: 杂志文章,随机对照试验


    authors: Choi E,Park Y,Jeon Y

    更新日期:2017-03-01 00:00:00

  • Stereotactic radiotherapy in neovascular age-related macular degeneration: Real-life efficacy and morphological evaluation of the outer retina-choroid complex.

    abstract::Stereotactic radiotherapy (SRT) is a new approach to treat neovascular age-related macular degeneration (nAMD). The INTREPID trial suggested that SRT could reduce the frequency of regular intravitreal injections (IVIs) with antivascular endothelial growth factor drugs, which are necessary to control disease activity. ...


    pub_type: 杂志文章


    authors: Ranjbar M,Kurz M,Holzhey A,Melchert C,Rades D,Grisanti S

    更新日期:2016-12-01 00:00:00

  • Prevalence of CD30 immunostaining in neoplastic mast cells: A retrospective immunohistochemical study.

    abstract::Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast c...


    pub_type: 杂志文章


    authors: Russano de Paiva Silva G,Tournier E,Sarian LO,Bulai-Livideanu C,Delsol G,Lamant L,Vassallo J,Brousset P,Laurent C

    更新日期:2018-05-01 00:00:00

  • Application of vascularized fibular graft for reconstruction and stabilization of multilevel cervical tuberculosis: A case report.

    abstract::Multilevel cervical reconstruction and fusion after cervical tuberculosis has always been a challenge. The current implantation materials for cervical fusion, including titanium mesh, cage, and plate are limited by its inferior biological mechanical characteristics and the properties of the metallic material. This has...


    pub_type: 杂志文章


    authors: Zhang J,He WS,Wang C,Yan YG,Ouyang ZH,Xue JB,Li XL,Wang WJ

    更新日期:2018-01-01 00:00:00

  • Therapeutic effect of enterprise stent-assisted embolization for very small ruptured intracranial aneurysms.

    abstract::Enterprise stent has been widespread used in wide-necked intracranial aneurysms and good efficacy has been achieved, but there are few reports on its applications in very small ruptured intracranial aneurysms in literatures. This study aimed to evaluate the safety and efficacy of Enterprise stent-assisted coiling embo...


    pub_type: 杂志文章


    authors: Qin F,Li Z,Fang X,Zhao X,Liu J,Wu D,Lai N

    更新日期:2017-08-01 00:00:00

  • The association between normal-range admission potassium levels in Israeli patients with acute coronary syndrome and early and late outcomes.

    abstract::Abnormal serum potassium levels are associated with an increased risk of ventricular arrhythmias and mortality in patients with acute myocardial infarction (AMI). The aim of the present study was to evaluate whether different levels of serum potassium, within the normal range, are associated with worse outcomes. The p...


    pub_type: 杂志文章,多中心研究


    authors: Shlomai G,Berkovitch A,Pinchevski-Kadir S,Bornstein G,Leibowitz A,Goldenberg I,Grossman E

    更新日期:2016-06-01 00:00:00

  • Long-term survival and death causes of systemic lupus erythematosus in China: a systemic review of observational studies.

    abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an increased risk of death compared to general population. Although previous studies showed improvement in survival of SLE, the long-term prognosis has not been elaborated in China.This study aims to integrate the observational studies estimating ...


    pub_type: 杂志文章,评审


    authors: Wang Z,Wang Y,Zhu R,Tian X,Xu D,Wang Q,Wu C,Zhang S,Zhao J,Zhao Y,Li M,Zeng X

    更新日期:2015-05-01 00:00:00

  • Radiofrequency ablation for lung squamous cell carcinoma in a single-lung patient: A case report and literature review.

    abstract:RATIONALE:High morbidity and high mortality are the main features of non-small cell lung cancer (NSCLC). Radiofrequency ablation, which produces a large amount of heat to kill tumor cells, is one effective way to treat this disease. PATIENT CONCERNS:We report the case of a 74-year-old man who presented with a 1-month ...


    pub_type: 杂志文章,评审


    authors: Song GQ,Li GG,Chen F,Chen DS,Qian HJ,Deng XE,Lu HQ,Lin B

    更新日期:2019-06-01 00:00:00

  • Identification of volume parameters monitored with a noninvasive ultrasonic cardiac output monitor for predicting fluid responsiveness in children after congenital heart disease surgery.

    abstract::No previous study has used an ultrasonic cardiac output monitor (USCOM) to assess volume parameters, such as stroke volume variation (SVV), in order to predict the volume status and fluid responsivenes in children after congenital heart disease (CHD) surgery. The present prospective trial aimed to investigate the abil...


    pub_type: 临床试验,杂志文章


    authors: Cheng YW,Xu F,Li J

    更新日期:2018-09-01 00:00:00

  • Granulomatous lymphadenitis mimicking metastatic lymphadenopathy in the neck after lymphatic embolization of chyle leakage: A case report.

    abstract:RATIONALE:Lymphatic embolization is a minimally invasive treatment option for managing chyle leakage after nodal dissection in the neck. After the procedure, the embolic material may cause foreign body granulomatous lymphadenitis and can be a diagnostic challenge for radiologists because of sonographic similarity to me...


    pub_type: 杂志文章


    authors: Ryu KH,Baek HJ,Cho SB,An HJ,Kim JP

    更新日期:2018-10-01 00:00:00

  • Clinical features of Crohn disease concomitant with ankylosing spondylitis: A preliminary single-center study.

    abstract::Extraintestinal manifestations (EIMs) cause increased morbidity and decreased quality of life in Crohn disease (CD). Ankylosing spondylitis (AS) belongs to EIMs. Very little is known on the clinical features of CD concomitant with AS. This study is to investigate the clinical features of CD patients with AS.We retrosp...


    pub_type: 杂志文章


    authors: Liu S,Ding J,Wang M,Zhou W,Feng M,Guan W

    更新日期:2016-07-01 00:00:00

  • Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients.

    abstract::We conducted the current study to investigate the clinical, laboratory, and histologic features at presentation and the outcome of renal sarcoidosis (RS). Exhaustive retrospective data were collected by the French Sarcoidosis Group. Forty-seven adult patients were assessed (30 male/17 female, M/F ratio: 1.76). Median ...


    pub_type: 杂志文章,多中心研究


    authors: Mahévas M,Lescure FX,Boffa JJ,Delastour V,Belenfant X,Chapelon C,Cordonnier C,Makdassi R,Piette JC,Naccache JM,Cadranel J,Duhaut P,Choukroun G,Ducroix JP,Valeyre D

    更新日期:2009-03-01 00:00:00

  • Complete laparoscopic cholecystectomy for a duplicated gallbladder: A case report.

    abstract:INTRODUCTION:Duplication of the gallbladder (GB) is a rare congenital abnormality occurring in 1 in 4000 to 5000 births. Three types have been reported: type I (split primordial GB), type II (2 separate GBs with their own cystic ducts), and type III (triple GBs drained by 1 to 3 separate cystic ducts). Patients with a ...


    pub_type: 杂志文章


    authors: Zhou DK,Huang Y,Kong Y,Ye Z,Ying LX,Wang WL

    更新日期:2020-01-01 00:00:00

  • The renoprotective effects of simvastatin and atorvastatin in patients with acute coronary syndrome undergoing percutaneous coronary intervention: An observational study.

    abstract::Some statins, such as atorvastatin, have proven renoprotective effects. The comparative renoprotective potential of simvastatin is less clear. This study aimed to compare the renoprotective effects of simvastatin with atorvastatin in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary interven...


    pub_type: 杂志文章


    authors: Ma H,Liu Y,Xie H,Zhang G,Zhan H,Liu Z,Wang P,Geng Q,Guo L

    更新日期:2017-08-01 00:00:00

  • Effect of dexmedetomidine as an adjuvant to ropivacaine for wound infiltration in patients undergoing open gastrectomy: A prospective randomized controlled trial.

    abstract:OBJECTIVES:The primary objective of this study was to investigate whether dexmedetomidine could potentiate the analgesic efficacy of ropivacaine, when added to ropivacaine for wound infiltration in patients undergoing open gastrectomy. METHODS:Fifty patients scheduled for open gastrectomy were divided into 2 equal gro...


    pub_type: 杂志文章,随机对照试验


    authors: Luan H,Zhu P,Zhang X,Tian L,Feng J,Wu Y,Yan Y,Zhao Z,Gu X

    更新日期:2017-09-01 00:00:00

  • Formation of the calcarine sulcus: a potential marker to predict the progression in utero of isolated mild fetal ventriculomegaly.

    abstract::Our previous study confirmed the negative association between the development of calcarine sulcus and the width of lateral ventricles. The purpose of current study was to evaluate the reliability of calcarine sulcus depth in the 2nd trimester to predict the prenatal enlargement of lateral ventricle in fetuses with iso...


    pub_type: 杂志文章


    authors: Li H,Liu G,Lin F,Liang H

    更新日期:2017-07-01 00:00:00

  • Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report.

    abstract:RATIONALE:Sodium valproate (VPA) and lamotrigine (LTG) are widely used antiepileptic drugs, disabling postural, and action tremors after using LTG with VPA were reported in 1993. However, in this study, we describe a patient in whom disabling resting-type tremor induced by 2-year use of VPA and LTG. PATIENT CONCERNS:A...


    pub_type: 杂志文章


    authors: He ZF,Chen J,Zhou CN,Rao Z,Wang XH

    更新日期:2017-11-01 00:00:00

  • Outcome in noncritically ill patients with acute kidney injury requiring dialysis: Effects of differing medical staffs and organizations.

    abstract::Acute kidney injury requiring dialysis (AKI-D) treatment has significantly increased in incidence over the years, with more than 400 new cases per million population/y, 2/3 of which concern noncritically ill patients. In these patients, there are little data on mortality or on information of care organization and its ...


    pub_type: 杂志文章


    authors: Fagugli RM,Patera F,Battistoni S,Tripepi G

    更新日期:2016-07-01 00:00:00

  • A new sensitive and accurate model to predict moderate to severe obstructive sleep apnea in patients with obesity.

    abstract::Obstructive sleep apnea (OSA) has a high prevalence in patients with obesity. Only patients with clinical symptoms of OSA are admitted to polysomnography; however, many patients with OSA are asymptomatic. We aimed to create and validate a population-based risk score that predicts the severity of OSA in patients with o...


    pub_type: 杂志文章


    authors: Ahlin S,Manco M,Panunzi S,Verrastro O,Giannetti G,Prete A,Guidone C,Berardino ADM,Viglietta L,Ferravante A,Mingrone G,Mormile F,Capristo E

    更新日期:2019-08-01 00:00:00

  • Sudden death due to traumatic ascending aortic pseudoaneurysms ruptured into the esophagus: 2 case reports.

    abstract::We present 2 rare cases of patients with uncontrolled hemorrhagic shock induced by traumatic ascending aortic pseudoaneurysm rupture into the esophagus. Two men were presented to the hospital after traffic accidents. Their chest radiograph showed no obvious signs of aortic damage or aortic pseudoaneurysms but only a s...


    pub_type: 杂志文章


    authors: He S,Chen X,Zhou X,Hu Q,Ananda S,Zhu S

    更新日期:2015-04-01 00:00:00

  • CONSORT-Independent prognostic value of asphericity of pretherapeutic F-18 FDG uptake by primary tumors in patients with breast cancer.

    abstract:BACKGROUND:The aim of this study was to evaluate the prognostic implication of asphericity (ASP); spatial irregularity; of pretherapeutic F 2-deoxy-2-fluoro-D-glucose (F FDG) tumor uptake in patients with invasive ductal carcinoma (IDC) of the breast. METHODS:One hundred thirty-one female IDC patients (mean age = 48.1...


    pub_type: 临床试验,杂志文章


    authors: Jung JH,Son SH,Kim DH,Lee J,Jeong SY,Lee SW,Park HY,Lee J,Ahn BC

    更新日期:2017-11-01 00:00:00

  • A High Circulating Tumor Cell Count in Portal Vein Predicts Liver Metastasis From Periampullary or Pancreatic Cancer: A High Portal Venous CTC Count Predicts Liver Metastases.

    abstract::Circulating tumor cells (CTCs) released from a periampullary or pancreatic cancer can be more frequently detected in the portal than the systemic circulation and potentially can be used to identify patients with liver micrometastases. Aims of this study is to determine if CTCs count in portal venous blood of patients ...


    pub_type: 杂志文章


    authors: Tien YW,Kuo HC,Ho BI,Chang MC,Chang YT,Cheng MF,Chen HL,Liang TY,Wang CF,Huang CY,Shew JY,Chang YC,Lee EY,Lee WH

    更新日期:2016-04-01 00:00:00

  • The association between IUGR and maternal inherited thrombophilias: A case-control study.

    abstract::One of the risk factors for vascular obstetric complications, such as intrauterine growth restriction (IUGR), is inherited thrombophilias. Nevertheless, routine screening for thrombophilias is not endorsed in pregnant women due to their low prevalence and conflicting results of published studies regarding the usefulne...


    pub_type: 杂志文章


    authors: Dugalić S,Petronijevic M,Stefanovic A,Jeremic K,Petronijevic SV,Soldatovic I,Pantic I,Djunic I,Jokic Z,Djokovic F,Dotlic J,Zaric M,Todorovic J

    更新日期:2018-10-01 00:00:00

  • Investigation and estimation of the prevalence of drug addicts in Xichang, china.

    abstract::To use a new method to estimate the prevalence of drug addicts in Xichang for the first time and to suggest that Chinese Center for Disease Control and Prevention should strengthen surveillance and intervention for them.The Capture-Mark-Recapture (CMR) method of 3 correlated sources under the simple random sampling an...


    pub_type: 杂志文章


    authors: Chen K,Bian C,Song B,Gao G

    更新日期:2019-01-01 00:00:00

  • The high prevalence of hypovitaminosis d in china: a multicenter vitamin d status survey: erratum.

    abstract::[In the article "The High Prevalence of Hypovitaminosis D in China: A Multicenter Vitamin D Status Survey", which appeared in Volume 94, Issue 8 of Medicine, several corrections were required regarding various manufacturer locations. The article has since been corrected online.]. ...


    pub_type: 杂志文章,已发布勘误



    更新日期:2015-03-01 00:00:00

  • Effect of prenatal and postnatal malnutrition on intellectual functioning in early school-aged children in rural western China.

    abstract::The aim of this study was to evaluate the effect of prenatal and postnatal malnutrition on the intellectual functioning of early school-aged children. We followed the offspring of women who had participated in a trial of prenatal supplementation with different combinations of micronutrients and who remained resident i...


    pub_type: 杂志文章


    authors: Li C,Zhu N,Zeng L,Dang S,Zhou J,Yan H

    更新日期:2016-08-01 00:00:00