Abstract:
BACKGROUND:Chlamydia pneumoniae is a common human pathogen that is associated with upper and lower respiratory tract infections. It has also been suggested that C. pneumoniae infection can trigger or promote a number of chronic inflammatory conditions, including asthma and atherosclerosis. Several strains of C. pneumoniae have been isolated from humans and animals, and sequence data demonstrates marked genetic conservation, leaving unanswered the question as to why chronic inflammatory conditions may occur following some respiratory-acquired infections. METHODS:C. pneumoniae strains AR39 and AO3 were used in vitro to infect murine bone marrow derived macrophages and L929 fibroblasts, or in vivo to infect C57BL/6 mice via the intranasal route. RESULTS:We undertook a comparative study of a respiratory isolate, AR39, and an atheroma isolate, AO3, to determine if bacterial growth and host responses to infection varied between these two strains. We observed differential growth depending on the host cell type and the growth temperature; however both strains were capable of forming plaques in vitro. The host response to the respiratory isolate was found to be more inflammatory both in vitro, in terms of inflammatory cytokine induction, and in vivo, as measured by clinical response and lung inflammatory markers using a mouse model of respiratory infection. CONCLUSIONS:Our data demonstrates that a subset of C. pneumoniae strains is capable of evading host innate immune defenses during the acute respiratory infection. Further studies on the genetic basis for these differences on both the host and pathogen side could enhance our understanding how C. pneumoniae contributes to the development chronic inflammation at local and distant sites.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
He X,Liang Y,LaValley MP,Lai J,Ingalls RRdoi
10.1186/s12866-015-0569-3subject
Has Abstractpub_date
2015-10-23 00:00:00pages
228issn
1471-2180pii
10.1186/s12866-015-0569-3journal_volume
15pub_type
杂志文章相关文献
BMC MICROBIOLOGY文献大全abstract:BACKGROUND:Microbiome and metagenomic studies have given rise to a new understanding of microbial colonization of various human tissues and their ability to impact our health. One human microbiome growing in notoriety, the vaginal microbiome, stands out given its importance for women's health, and is peculiar in terms ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-02027-8
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Several plant-pathogenic bacteria are transmitted by insect vector species that often also act as hosts. In this interface, these bacteria encounter plant endophytic, insect endosymbiotic and other microbes. Here, we used high throughput sequencing to examine the bacterial communities of five different psyll...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01895-4
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Candida parapsilosis typically is a commensal of human skin. However, when host immune defense is compromised or the normal microflora balance is disrupted, C. parapsilosis transforms itself into an opportunistic pathogen. Candida-derived lipase has been identified as potential virulence factor. Even though ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-122
更新日期:2011-05-29 00:00:00
abstract:BACKGROUND:The natural product Emodin demonstrates a wide range of pharmacological properties including anticancer, anti-inflammatory, antiproliferation, vasorelaxant and anti-H. pylori activities. Although its H. pylori inhibition was discovered, no acting target information against Emodin has been revealed to date. ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-91
更新日期:2009-05-12 00:00:00
abstract:BACKGROUND:Following genital chlamydial infection, an early T helper type 1 (Th1)-associated immune response precedes the activation and recruitment of specific Th1 cells bearing distinct chemokine receptors, subsequently leading to the clearance of Chlamydia. We have shown that CCR5, a receptor for CCL5, is crucial fo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-136
更新日期:2008-08-13 00:00:00
abstract:BACKGROUND:Fecal microbiota transplantation (FMT) has been recently approved by FDA for the treatment of refractory recurrent clostridial colitis (rCDI). Success of FTM in treatment of rCDI led to a number of studies investigating the effectiveness of its application in the other gastrointestinal diseases. However, in ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1689-y
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:The genus Phytophthora includes a group of agriculturally important pathogens and they are commonly regarded as water molds. They produce motile zoospores that can move via water currents and on their own locomotion in aquatic environments. However, zoosporic response to dissolved oxygen, an important water ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-124
更新日期:2014-05-13 00:00:00
abstract:BACKGROUND:The kinetoplast DNA (kDNA) of trypanosomatids consists of an unusual arrangement of circular molecules catenated into a single network. The diameter of the isolated kDNA network is similar to that of the entire cell. However, within the kinetoplast matrix, the kDNA is highly condensed. Studies in Crithidia f...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-120
更新日期:2009-06-04 00:00:00
abstract:BACKGROUND:In humans, the intestinal microbiota plays an important role in the maintenance of host health by providing energy, nutrients, and immunological protection. Applying current molecular methods is necessary to surmount the limitations of classical culturing techniques in order to obtain an accurate description...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-123
更新日期:2009-06-09 00:00:00
abstract:BACKGROUND:Hfq is a widely conserved bacterial RNA-binding protein which generally mediates the global regulatory activities involv ed in physiological process and virulence. The goal of this study was to characterize the biological function of hfq gene in Xanthomonas axonpodis pv. citri (Xac), the causal agent of citr...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1476-9
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:The Rio Grande River is the natural boundary between U.S. and Mexico from El Paso, TX to Brownsville, TX. and is one of the major water resources of the area. Agriculture, farming, maquiladora industry, domestic activities, as well as differences in disposal regulations and enforcement increase the contamina...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-4-17
更新日期:2004-04-22 00:00:00
abstract:BACKGROUND:The currently used genotyping system for the avian zoonotic pathogen Chlamydophila (C.) psittaci has evolved from serology and is based on ompA sequence variations. It includes seven avian and two non-avian genotypes. Restriction enzyme cleavage of the amplified ompA gene and, less frequently, ompA sequencin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-63
更新日期:2008-04-17 00:00:00
abstract:BACKGROUND:Quinolone resistant Escherichia coli (QREC) have been found in samples from Norwegian broiler chicken, despite quinolones not being administered to poultry in Norway. Biofilm production may be one factor contributing to the observed persistence in the broiler production chain. In the present study, 158 QREC ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01730-w
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:Streptococcus agalactiae (GBS) is a common pathogen to infect newborn, woman, the elderly, and immuno-compromised human and fish. 37 fish isolates and 554 human isolates of the GBS in 2007-2012 were investigated in serotypes, antibiotic susceptibility, genetic difference and pathogenicity to tilapia. RESULT...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-016-0794-4
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:Xanthophyllomyces dendrorhous is a basidiomycetous yeast that synthesizes astaxanthin, a carotenoid with great biotechnological impact. The ergosterol and carotenoid synthetic pathways derive from the mevalonate pathway and involve cytochrome P450 enzymes. Among these enzymes, the CYP51 family, which is invo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0428-2
更新日期:2015-04-25 00:00:00
abstract:BACKGROUND:Similar to Gram-negative bacteria, the outer membrane (OM) of the pathogenic spirochete, Borrelia burgdorferi, contains integral OM-spanning proteins (OMPs), as well as membrane-anchored lipoproteins. Although the mechanism of OMP biogenesis is still not well-understood, recent studies have indicated that a ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-60
更新日期:2012-04-20 00:00:00
abstract:BACKGROUND:Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores. Although iron transport systems involved in the pathogenesis of APEC or UPEC ha...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-143
更新日期:2012-07-20 00:00:00
abstract:BACKGROUND:Streptococcus pneumoniae is a common respiratory pathogen and a major causative agent of respiratory infections, including otitis media (OM). Pneumococcal biofilms have been demonstrated on biopsies of the middle ear mucosa in children receiving tympanostomy tubes, supporting the hypothesis that chronic OM m...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-173
更新日期:2008-10-08 00:00:00
abstract:BACKGROUND:Campylobacter jejuni is a leading foodborne pathogen worldwide. Despite the fastidious nature of C. jejuni growth, increasing numbers of human campylobacteriosis suggest that C. jejuni may possess unique mechanisms to survive under various stress conditions. C. jejuni possesses only three sigma factors (FliA...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-207
更新日期:2011-09-22 00:00:00
abstract:BACKGROUND:Streptococcus gordonii is one of several species that can initiate the formation of oral biofilms that develop into the complex multispecies microbial communities referred to as dental plaque. It is in the context of dental plaque that periodontal pathogens such as Porphyromonas gingivalis cause disease. We ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-211
更新日期:2012-09-18 00:00:00
abstract:BACKGROUND:Adenosine triphosphate (ATP) is used as an intracellular energy source by all living organisms. It plays a central role in the respiration and metabolism, and is the most important energy supplier in many enzymatic reactions. Its critical role as the energy storage molecule makes it extremely valuable to all...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-301
更新日期:2013-12-24 00:00:00
abstract:BACKGROUND:Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0550-1
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Many bacterial extracytoplasmic proteins are stabilized by intramolecular disulfide bridges that are formed post-translationally between their cysteine residues. This protein modification plays an important role in bacterial pathogenesis, and is facilitated by the Dsb (disulfide bond) family of the redox pro...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-166
更新日期:2011-07-25 00:00:00
abstract:BACKGROUND:Previous phylogenetic analyses of species within the genus Golovinomyces (Ascomycota, Erysiphales), based on ITS and 28S rDNA sequence data, revealed a co-evolutionary relationship between powdery mildew species and hosts of certain tribes of the plant family Asteraceae. Golovinomyces growing on host plants ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01731-9
更新日期:2020-03-05 00:00:00
abstract:BACKGROUND:Streptomyces lividans is an appealing host for the production of proteins of biotechnological interest due to its relaxed exogenous DNA restriction system and its ability to secrete proteins directly to the medium through the major Sec or the minor Tat routes. Often, protein secretion displays non-uniform ti...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1591-7
更新日期:2019-10-26 00:00:00
abstract:BACKGROUND:Escherichia coli is a well-studied anaerobic bacteria which is able to regulate metabolic pathways depending on the type of sugar presented in the medium. We have studied the glucose-lactose shift in E. coli at the protein level using a recently developed mass spectrometry platform. METHOD:Cells were grown ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-126
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The increase in resistance to antibiotics among disease-causing bacteria necessitates the development of alternative antimicrobial approaches such as the use of light-activated antimicrobial agents (LAAAs). Light of an appropriate wavelength activates the LAAA to produce cytotoxic species which can then caus...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-111
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Pectobacterium carotovorum subsp. carotovorum is a phytopathogenic enterobacterium responsible for soft rot, a disease characterized by extensive maceration of the affected plant tissue. This species also produces two or more antibacterial substances called bacteriocins, which enhance its competitiveness aga...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-181
更新日期:2009-08-27 00:00:00
abstract:BACKGROUND:Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this s...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01916-2
更新日期:2020-07-28 00:00:00
abstract:BACKGROUND:The high demand for ethanol in the U.S. has generated large stocks of wet distillers grains (DG), a byproduct from the manufacture of ethanol from corn and sorghum grains. Little is known, however, about the potential influence of dietary DG on fecal microbial community structure. A better understanding of t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-25
更新日期:2012-02-24 00:00:00