Whole-Body Diffusion Tensor Imaging: A Feasibility Study.

Abstract:

OBJECTIVE:The aim of this study was to demonstrate the feasibility of whole-body diffusion tensor imaging (DTI) as a promising tool for research applications, for instance, for investigation of systemic muscle diseases. MATERIALS AND METHODS:Twelve healthy volunteers (mean age, 26.6 years; range, 20-39 years) underwent whole-body magnetic resonance imaging at 3 T using an echo planar imaging sequence (b value, 400 s/mm) with 6 different spatial encoding directions. Coronal maps of DTI parameters including mean diffusivity, fractional anisotropy, and diffusion tensor eigenvalues (λ1-3) were generated using in-house MATLAB routines. Diffusion tensor imaging parameters were evaluated by region-of-interest analysis in skeletal muscle, cerebral gray and white matter, the kidneys, and the liver. RESULTS:The acquisition time was 79 minutes 12 seconds. The different organs could be clearly depicted on the parametrical maps. Exemplary values in skeletal muscle were mean diffusivity, 1.67 ± 0.16 × 10(-3) mm2/s; fractional anisotropy, 0.26 ± 0.03; λ1, 2.17 ± 0.20 × 10(-3) mm2/s; λ2, 1.64 ± 0.17 × 10(-3) mm2/s; and λ3, 1.22 ± 0.12 × 10(-3) mm2/s. CONCLUSION:Whole-body DTI is technically feasible. Further refinements are required to achieve a higher signal-to-noise ratio and improved spatial resolution. A possible clinical application could be the assessment of systemic myopathies.

journal_name

J Comput Assist Tomogr

authors

Kenkel D,von Spiczak J,Wurnig MC,Filli L,Steidle G,Wyss M,Boss A

doi

10.1097/RCT.0000000000000324

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

183-8

issue

1

eissn

0363-8715

issn

1532-3145

journal_volume

40

pub_type

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