Gadolinium-phthalein complexone as a contrast agent for hepatobiliary MR imaging.

Abstract:

:Gadolinium-phthalein complexone (Gd-PC) was developed as a hepatobiliary magnetic resonance (MR) contrast agent. Phthalein complexone is one of the iminodiacetic acid derivatives and a structural analogue of bromosulfophthalein. Gadolinium-PC substantially enhanced signal intensity of normal functioning livers on T1-weighted MR images. Contrast enhancement of rabbit liver and gradual accumulation of high intensity bile in the gallbladder were observed after intravenous injection of 0.05 and 0.1 mmol/kg Gd-PC. However, 0.1 mmol/kg of Gd-DTPA caused little effect on liver MR.

journal_name

J Comput Assist Tomogr

authors

Kawamura Y,Endo K,Koizumi M,Watanabe Y,Saga T,Konishi J,Horiuchi K,Yokoyama A

doi

10.1097/00004728-198901000-00014

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

67-70

issue

1

eissn

0363-8715

issn

1532-3145

journal_volume

13

pub_type

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