Abstract:
:Quantitation of regional myocardial blood flow (MBF) in absolute terms with positron emission tomography (PET) has been difficult to achieve in part because of errors induced by the relatively low spatial resolution of current tomographic instruments. We previously demonstrated that MBF could be accurately measured over a wide range of flows after intravenous administration of H2 15O when the arterial input function and myocardial radiotracer content were measured directly. To extend this quantitative approach for noninvasive estimates of MBF with PET. We recently developed and implemented a novel mathematical approach whereby partial volume and spillover effects were estimated along with flow within the operational one-compartment flow equation. Noninvasive estimates of flow correlated closely with flow measured directly with radiolabeled microspheres. In the present study, with the use of a commercially available cardiac phantom, we assessed our ability to obtain true time-activity curves from observed PET data contaminated by partial volume and spillover effects. Computer simulations demonstrated that the approach developed is relatively insensitive to most potential sources of error, but is sensitive to timing discrepancies between the arterial input function and the tissue time-activity curve. Implementation of this approach provides accurate quantitation of regional MBF in absolute terms and should be useful in noninvasive evaluation of the efficacy of treatments designed to enhance nutritional perfusion in human subjects.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Herrero P,Markham J,Bergmann SRdoi
10.1097/00004728-198909000-00021subject
Has Abstractpub_date
1989-09-01 00:00:00pages
862-73issue
5eissn
0363-8715issn
1532-3145journal_volume
13pub_type
杂志文章abstract::Proper therapeutic management of acute spinal trauma depends considerably on the assessment of the condition of the underlying spinal cord and the relative stability of the surrounding bony architecture. A series of 14 patients who were examined by magnetic resonance (MR) imaging following spinal trauma is presented. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198705000-00008
更新日期:1987-05-01 00:00:00
abstract::Idiopathic muscular hypertrophy of the esophagus is a rare, benign esophageal disease, characterized by hyperplasia of all layers of the wall and, in particular, muscle layers. The authors describe the CT findings and review the relevant literature. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198811000-00026
更新日期:1988-11-01 00:00:00
abstract::Masses arising in the adrenal gland may be simulated on computed tomography (CT) by a number of anatomical structures and variations, and by certain pathological conditions in adjacent organs. These adrenal pseudotumors include the following: fluid-filled gastric fundus, prominent splenic lobulations, upper pole renal...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198204000-00009
更新日期:1982-04-01 00:00:00
abstract::We report a case of an extramedullary plasmacytoma arising from the nasopharynx. The computed tomographic appearance of this rare tumor is discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198312000-00028
更新日期:1983-12-01 00:00:00
abstract::The direct spread of intraabdominal disease via peritoneal folds is clearly demonstrated with computed tomography (CT). This extensive network of peritoneal folds can be conceptualized as the subperitoneal space. These subperitoneal communications within the abdomen are described and demonstrated by CT scans and a sch...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198212000-00014
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to describe the computed tomographic features of organizing pneumonia (OP) in an oncologic patient population and to also identify features associated with lung cancer and patients undergoing hematopoietic stem cell transplant (HSCT). METHODS:In retrospective computed tomographies...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000520
更新日期:2017-05-01 00:00:00
abstract::A new head holder for the fixation and repositioning of the patient head in PET, CT, and MR scanners has been designed and tested. With this device, a bidimensional correlation between functional and anatomical brain images can also be obtained. Head fixation and repositioning are achieved using the patient's dental m...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199109000-00034
更新日期:1991-09-01 00:00:00
abstract:PURPOSE:To describe CT findings of portal vein anomaly with total ramification of the intrahepatic portal branches from the right umbilical vein. METHODS:Retrospective analysis was performed in 6 patients with portal vein anomaly with total ramification of the intrahepatic portal branches from the right umbilican vein...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000165905.06031.b0
更新日期:2005-07-01 00:00:00
abstract::Two projection algorithms are currently available for viewing computed tomography (CT) data sets: average projection (AVG) and maximum intensity projection (MIP). Although AVG images feature good suppression of image noise but reduced edge sharpness, MIP images are characterized by good edge sharpness but also amplify...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31812e4b37
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the image quality of renal arteries and veins with dual-energy spectral computed tomography (CT) imaging in late arterial phase using 270 and 320 mg I/mL of iodixanol and their influence on renal function. METHODS:A total of 1062 patients underwent renal CT angiogra...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000595
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:Recently, a new specific organ dose adaption and reduction protocol, or SODAR tool (X-CARE, Siemens Healthcare), which reduces dose to the anterior aspect of the body of patients, was installed on our computed tomographic scanner. The purpose of this pilot project was to evaluate image quality and dose distribu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318251ec61
更新日期:2012-05-01 00:00:00
abstract::This paper will review the lumbosacral spine (L1-S5). Procedures performed in the lumbosacral spine include electromyography, spinal stimulator implants, spinal infusion implants for spasticity or pain medications, sacroiliac spine injections, facet blocks, and steroid injections. Complications from these procedures i...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181560a51
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:Our goal was to perform a detailed comparison of the relative performances of helical CT (pitches 1.0, 1.5, and 2.0) and conventional (overlapped and nonoverlapped) CT in detailed 3D and MPR musculoskeletal imaging. METHOD:A specially designed bone fragment phantom was imaged with multiple slice thicknesses us...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199701000-00031
更新日期:1997-01-01 00:00:00
abstract::Retroperitoneal fat necrosis is a well-known complication of acute pancreatitis. We describe an unusual case of fat necrosis presenting as multiple, bilateral renal pseudotumors in a patient with acute pancreatitis. The imaging findings on CT and MR are discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200103000-00014
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics. METHODS:Fifty-one subjects were explored with phase-contrast cine MR imaging. There were 36 volunteers, 9 patients with normal pressure hydrocephalus (NPH), and 6 patients with asymptomatic ventricular d...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200403000-00015
更新日期:2004-03-01 00:00:00
abstract::This report describes the imaging findings of the first reported case of a bronchobiliary fistula that developed as a complication of liver transplantation. The diagnosis was confirmed by the aspiration of bile from the bronchus. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000131583.52386.cf
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the Macklin effect in patients with spontaneous pneumomediastinum by multidetector-row computed tomography (MDCT). METHODS:Chest computed tomography (CT) reports between July 2000 and January 2003 at our institution were retrospectively reviewed. Nine patients with s...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000187416.07698.8d
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to demonstrate the feasibility of whole-body diffusion tensor imaging (DTI) as a promising tool for research applications, for instance, for investigation of systemic muscle diseases. MATERIALS AND METHODS:Twelve healthy volunteers (mean age, 26.6 years; range, 20-39 years) underwen...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000324
更新日期:2016-01-01 00:00:00
abstract::Two cases of von Recklinghausen neurofibromatosis (VRN) with thoracic and abdominal involvement are described. Computed tomography demonstrated the typical lesions of this disease: meningoceles, neurofibromas, and skeletal alterations. In both cases lesion morphology and location were similar and characteristic, in pa...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00021
更新日期:1983-10-01 00:00:00
abstract::In a consecutive group of 1,067 noncholecystectomized patients referred for computed tomography including the upper abdomen, gallstones were seen in 13%. In 4% of the patients with gallstones, gas-containing calculi were found. On reviewing the conventional plain films such stones were revealed in less than one-half o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00009
更新日期:1983-10-01 00:00:00
abstract:PURPOSE:Our purpose was to determine what represents normal findings on MR examinations of the lumbar spine in the immediately postoperative period following lumbar laminectomy with retained Surgicel. METHOD:MR examinations were performed immediately following lumbar laminectomy in 10 patients referred for symptoms of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199911000-00029
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation. METHODS:Coronary arteries (n = 5) with early atherosclerotic changes were injected with Microfil...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181bb0d32
更新日期:2010-03-01 00:00:00
abstract::Fast MR techniques and the application of water-soluble contrast agents allow the simultaneous examination of renal morphology and the functional aspects of glomerular filtration using bolus injections of Gd-DTPA. Spatial resolution is sufficient to resolve individual renal pyramids, but the quantitative examination o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199109000-00002
更新日期:1991-09-01 00:00:00
abstract::The typical MRI features of hydatid cyst in soft tissue/muscle are presented and discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199903000-00031
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:This study was designed to examine the use of quantitative magnetization transfer imaging (MTI) in naturally occurring globoid cell leukodystrophy (GLD) in the Cairn terrier. METHOD:A model of GLD was established via a breeding colony, and a total of seven animals were studied with MTI, including two dogs with...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200003000-00025
更新日期:2000-03-01 00:00:00
abstract::This article reviews the computed tomography imaging features of a variety of gastric tumors containing fatty tissue. Lipoma, angiolipoma, liposarcoma, and teratoma are described. Differential diagnosis includes primary and reactive lipomatosis, carcinoma engulfing the perivisceral fat thus mimicking differentiated li...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/00004728-200011000-00006
更新日期:2000-11-01 00:00:00
abstract::A case of Ebstein anomaly in a 2-day-old newborn is presented. The complementary roles of two-dimensional Doppler echocardiography and magnetic resonance imaging in managing this cardiac malformation are emphasized. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199009000-00032
更新日期:1990-09-01 00:00:00
abstract::We report a unique case of early-phase Takayasu arteritis in which the vessels demonstrated accumulation of [18F]fluorodeoxyglucose (FDG) on PET scanning. This observation suggests the possible use of FDG-PET for the diagnosis of vasculitis. Early diagnosis of Takayasu arteritis may permit early treatment and possibly...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199901000-00004
更新日期:1999-01-01 00:00:00
abstract::Four patients (three with hepatocellular carcinoma and one with colorectal carcinoma metastatic to the liver) previously treated with chemotherapy or radiotherapy or both in an attempt to reduce tumor bulk prior to surgical resection were examined by CT angiography (CTA). Areas of abnormal enhancement and irregular ve...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198807000-00007
更新日期:1988-07-01 00:00:00
abstract::Renal cell carcinoma has a propensity to extend as tumor thrombus into the renal vein and inferior vena cava (IVC). The preoperative assessment for the presence and extent of renal vein and IVC tumor thrombus is important for planning appropriate surgical resection. Imaging procedures [CT, ultrasound (US), MR, venacav...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199203000-00012
更新日期:1992-03-01 00:00:00