Intracranial fluid dynamics in normal and hydrocephalic states: systems analysis with phase-contrast magnetic resonance imaging.

Abstract:

OBJECTIVE:To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics. METHODS:Fifty-one subjects were explored with phase-contrast cine MR imaging. There were 36 volunteers, 9 patients with normal pressure hydrocephalus (NPH), and 6 patients with asymptomatic ventricular dilation (VD). The transfer function XFRA/CSF from the arterial pulse waves (APWs) and the CSF pulse waves (CSFPWs) and the transfer function XFRCSF/SS from the CSF pulse waves (CSFPWs) and the sagittal sinus pulse waves (SSPWs) were studied separately. RESULTS:There was a significant difference in the amplitude spectrum of the XFRA/CSF of patients with VD and volunteers (P < 0.05) and in that of patients with NPH and volunteers (P = 0.005). The amplitude of the fundamental frequency was higher in the NPH group than in the VD group (P = 0.02). In patients with NPH, the amplitude spectrum of XFRCSF/SS showed an attenuation of the pulse wave components that significantly differed from the observed amplification in healthy subjects (P = 0.009) and patients with VD (P = 0.012). CONCLUSION:This systems analysis method could help to detect increased venous compliance in VD and decreased venous compliance in NPH.

journal_name

J Comput Assist Tomogr

authors

de Marco G,Idy-Peretti I,Didon-Poncelet A,Baledent O,Onen F,Feugeas MC

doi

10.1097/00004728-200403000-00015

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

247-54

issue

2

eissn

0363-8715

issn

1532-3145

pii

00004728-200403000-00015

journal_volume

28

pub_type

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