Detection of renal ischemic lesions using Gd-DTPA enhanced turbo FLASH MRI: experimental and clinical results.

Abstract:

PURPOSE:Our goal was to investigate the role of Gd-DTPA-enhanced dynamic MRI in the evaluation of renal ischemic lesions. METHOD:With a turbo FLASH sequence before and after injection of Gd-DTPA, nine foxhound dogs after 60-120 min of renal ischemia underwent MR examination. In addition, five patients with a tumor in a solitary kidney were examined before and after nephron-sparing renal surgery to evaluate renal perfusion and function. The experimental and clinical findings were correlated with conventional measurements of kidney function and with histological findings. RESULTS:Complete renal ischemia leads to a poor corticomedullary differentiation in Gd-DTPA-enhanced turbo FLASH MRI. The signal-intensity-versus-time plots of kidneys with significant postischemic changes show a less steep increase of signal intensity in the cortex and a steeper increase of signal intensity in the medulla than those of normal kidneys. CONCLUSION:Dynamic MRI demonstrate renal morphology and reflect the functional status of renal vasculature.

journal_name

J Comput Assist Tomogr

authors

Vosshenrich R,Kallerhoff M,Gröne HJ,Fischer U,Funke M,Kopka L,Siebert G,Ringert RH,Grabbe E

doi

10.1097/00004728-199603000-00013

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

236-43

issue

2

eissn

0363-8715

issn

1532-3145

journal_volume

20

pub_type

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