Synergistic enhancement of MRI with Gd-DTPA and magnetization transfer.

Abstract:

:Magnetization transfer (MT) between protons of macromolecules and protons of water molecules is a recently introduced mechanism for tissue contrast in MR imaging. The MT effect is strong in tissues where there is an efficient cross relaxation between macromolecular protons and water protons and where this interaction is the dominant source of relaxation. Paramagnetic ions shorten relaxation times and decrease the MT effect. These two facts led to the assumption that, in the case of contrast enhanced MRI, the combination of the T1-weighted imaging method and the MT technique may yield increased contrast, compared with standard methods. The synergistic effect is demonstrated in this work with studies of egg white samples and by imaging three patients with different brain pathologies. The lesion-to-white matter contrasts, with standard T1-weighted sequences with and without the MT effect, were compared before and after the introduction of Gd-DTPA. In each case the synergistic effect of T1 weighting and MT improved the contrast enhancement provided with Gd-diethylenetriamine pentaacetic acid.

journal_name

J Comput Assist Tomogr

authors

Tanttu JI,Sepponen RE,Lipton MJ,Kuusela T

doi

10.1097/00004728-199201000-00004

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

19-24

issue

1

eissn

0363-8715

issn

1532-3145

journal_volume

16

pub_type

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