Abstract:
OBJECTIVE:Balò concentric sclerosis is a rare demyelinating disorder. Serial proton magnetic resonance spectroscopic (1H-MRS) studies were carried out to better understand the biochemical changes within concentric lesions. MATERIALS AND METHODS:Five concentric lesions in four patients with Balò concentric sclerosis were chosen as the objects of serial observation. They included two early acute lesions (showing as concentric ring enhancement on magnetic resonance imaging (MRI) after gadolinium administration), two late acute lesions (showing as marginal enhancement on MRI), and one early subacute lesion (showing as edematous concentric lesions without enhancement on MRI). The duration of follow-up ranged from 2-23 months (mean 10 months). A total of 20 1H-MRS studies were performed. On each 1H-MRS study, short-echo (30 ms) and long-echo (136 ms) spectra were obtained. The peaks of N-acetyl-asparate (NAA), choline-containing compounds (Cho), creatine and phosphocreatine (Cr), lactate, and mobile lipid were observed and compared. RESULTS:Generally, a decrease of NAA/Cr ratio and an increase of Cho/Cr ratio were seen on all the spectra. Observing longitudinally, a trend of decreasing NAA/Cr ratio first and then partially recovering later was noted. The lowest level of NAA/Cr ratio was noted at the late acute stage or early subacute stage. The Cho/Cr ratio and amplitude of the lactate peak showed a similar trend as that of NAA/Cr, but in an opposite direction. It was rising first and descending later. The highest levels of Cho/Cr ratio and lactate peak were also observed at the late acute or early subacute stage. In addition, lactate peaks could be detected as long as 7 months after onset of symptoms. Lipid metabolite (two broad peaks at 0.9-1.5 ppm) was seen at the initial study of each group, but fluctuated in size on follow-up. CONCLUSION:The characteristic biochemical changes of concentric sclerosis were a decreased NAA/Cr ratio, an increased Cho/Cr ratio, two broad peaks at 0.9-1.5 ppm, lactate production, and a reversible NAA/Cr ratio on follow-up. The serial 1H-MRS studies revealed a strong biochemical association between NAA, Cho, and lactate, which may be caused by the same pathogenetic process of demyelination and inflammatory cellular infiltration. The specificity of the serial changes may provide information about the stage of the concentric lesion and perhaps aid in monitoring progression of concentric lesions and evaluating therapy.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Chen CJdoi
10.1097/00004728-200109000-00008keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
713-8issue
5eissn
0363-8715issn
1532-3145pii
00004728-200109000-00008journal_volume
25pub_type
杂志文章abstract:OBJECTIVE:The aim of the study was to establish the reference window settings for display of virtual monoenergetic images (VMIs) from spectral detector computed tomography when assessing hypodense liver lesions. METHODS:In patients with cysts (n = 24) or metastases (n = 26), objective (HU, signal-to-noise ratio [SNR])...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000794
更新日期:2018-11-01 00:00:00
abstract::Eighteen patients with moyamoya disease were examined by computed tomography (CT). At the first examination, CT findings were normal in one patient and abnormal in 17 patients. Significant abnormalities on precontrast CT were characterized by low density lesions in 14, ventricular dilatation in 9, and cerebral atrophy...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198202000-00003
更新日期:1982-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine the accuracy of contrast-enhanced multidetector row computed tomography (MDCT) in classifying the morphological subtype and revealing the longitudinal extent of extrahepatic cholangiocarcinomas (EHCs). METHODS:Our institutional review board approved this retrospec...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318184f3f7
更新日期:2009-05-01 00:00:00
abstract::Gadolinium-phthalein complexone (Gd-PC) was developed as a hepatobiliary magnetic resonance (MR) contrast agent. Phthalein complexone is one of the iminodiacetic acid derivatives and a structural analogue of bromosulfophthalein. Gadolinium-PC substantially enhanced signal intensity of normal functioning livers on T1-w...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198901000-00014
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:: The aim of this study was to achieve the quantitative analysis of the characteristic computed tomography (CT) findings and course of interstitial pneumonia using the volume histogram method. METHODS:: Contrast (CNT), variance (VAR), and entropy (EPY) values from whole-lung volume data were compared betwee...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200603000-00014
更新日期:2006-03-01 00:00:00
abstract::Hepatic actinomycosis is an uncommon entity that forms communicating abscesses and fistulae. A case is presented in which findings on ultrasound, CT, and percutaneous injection of the abscess all reflected the pathologic process. Biopsy by thin-needle aspiration under CT guidance afforded prompt, accurate diagnosis an...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198603000-00035
更新日期:1986-03-01 00:00:00
abstract::We conducted a prospective evaluation of the normal vermiform appendix in 203 patients. Conventional CT techniques were utilized with an 8 mm slice thickness and 10 mm slice interval. The normal appendix was definitely identified in 51% of the patients studied. Computed tomographic appearance of the normal appendix is...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199107000-00009
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:The prevalence and features of the thyroid pyramidal lobe (TPL) on computed tomography (CT) have been reported, but no ultrasound (US) study has been found. The purposes of the current study were to assess the sonographic prevalence and features of TPLs and to compare the US and CT parameters of TPLs. METHOD...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000054
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:To investigate the optimal dual-energy reconstruction technique for the visualization of the hepatic arterial system during dual-energy multidetector computed tomographic (MDCT) angiography of the liver. MATERIALS AND METHODS:Twenty-nine nonconsecutive patients underwent dual-energy MDCT angiography of the liv...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000259
更新日期:2015-09-01 00:00:00
abstract::We describe a patient with a metastatic liver tumor that showed a cordlike shadow traversing the tumor on CT. Histopathologically, this cordlike shadow within the metastatic liver tumor was proved to be an infiltrated portal vein without blood flow surrounded by fibrous tissue. Vascular structures traversing a focal l...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199501000-00026
更新日期:1995-01-01 00:00:00
abstract::The magnetic resonance imaging characteristics of transient left ventricular apical ballooning are described in this report, and the features that distinguish it from acute myocardial infarction are emphasized. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000148454.67697.42
更新日期:2005-01-01 00:00:00
abstract::Three-dimensional volumetric rendering of CT data has proven to be valuable in the evaluation of the hip. Although video loop animation allows review of the anatomy from all perspectives, it does not show the functional range of motion of the femur in the acetabulum. We have developed a technique termed simulated dyna...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199101000-00019
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare chest digital tomosynthesis (DTS) and multidetector computed tomography (MDCT) for the detection of pulmonary ground-glass opacity (GGO) nodules and estimation of radiation dose using an anthropomorphic chest phantom and simulated nodules. MATERIALS AND METHODS:A male...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318266aa71
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Neonatal hypoxic-ischemic encephalopathy (HIE) is associated with dysfunctional cerebral autoregulation. Resistive index (RI) measured in the anterior cerebral artery on transfontanellar head ultrasound is a noninvasive measure of blood flow and may indicate autoregulation dysfunction. We tested whether RI w...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000001069
更新日期:2020-09-01 00:00:00
abstract::We report imaging findings in five patients who had sudden cardiac arrest during contrast-enhanced computed tomography (CT). We observed strikingly dense abdominal veins, variable degrees of arterial enhancement, and poor abdominal visceral enhancement. Comparison with a control group of 30 patients revealed a statist...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200301000-00017
更新日期:2003-01-01 00:00:00
abstract::Magnetic resonance (MR) imaging and CT were used in supporting the diagnosis of Leigh disease (subacute necrotizing encephalomyelopathy) in five patients. Two cases were confirmed at postmortem examination, and three patients have laboratory and/or clinical histories suggestive of Leigh disease. Four cases demonstrate...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198801000-00006
更新日期:1988-01-01 00:00:00
abstract::Fifteen prostates were obtained from patients autopsied at The Johns Hopkins Hospital and imaged fresh in vitro by high resolution magnetic resonance (MR) imaging with a surface coil. Following scanning, the specimens were fixed and sectioned in the same plane as the MR images. The prostate sections, corresponding to ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198711000-00022
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:X-Ray CT has the potential to provide precise and accurate data from which the mechanical properties of bone can be calculated. Such data would be useful in understanding the response of bone tissue to implants. Various artifacts can, however, degrade accuracy of the data. The aim of this study was to measure t...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199605000-00035
更新日期:1996-05-01 00:00:00
abstract::Of 700 neonates examined by computed tomography (CT) in a 4 years period, 17 were found to have a posterior fossa hemorrhage. Eleven were born at term, and six were premature. Delivery was traumatic in 12 babies. The hematoma was in the subdural space in nine and within the cerebellum in eight. The CT diagnosis of ext...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198102000-00013
更新日期:1981-02-01 00:00:00
abstract::Due to the low prevalence of hemangiopericytomas (HPCs), data on the biophysiological characteristics of this tumor are rare. Positron emission tomography (PET) demonstrated a sixfold increased uptake of [11C]methionine and hyperperfusion in the HPC, whereas glucose utilization was decreased in this area. This low glu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199905000-00008
更新日期:1999-05-01 00:00:00
abstract::The effect of hemodialysis on the CT absorption value of the liver was examined in 14 hemodialysis patients. In the high ultrafiltration group [10 patients with a weight loss of -1.7 to -3.5 (2.9 +/- 0.6) kg], the hepatic CT absorption value increased from 49.6 +/- 7.0 to 58.7 +/- 8.7 Hounsfield units (p less than 0.0...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198408000-00021
更新日期:1984-08-01 00:00:00
abstract::Temporomandibular joint (TMJ) disease is uncommon in children but frequently occurs in juvenile rheumatoid arthritis (JRA). Involvement is often asymptomatic; however, it can lead to growth disturbances and facial deformity. Thirty TMJs in 15 children (11 girls and 4 boys aged 3.5-18 years) with JRA were evaluated cli...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199305000-00022
更新日期:1993-05-01 00:00:00
abstract::Gas formation as a result of transcatheter tumor embolization has recently been observed by conventional radiography. We report the computed tomography identification of similar benign gas formation following transcatheter embolization of a large adrenal carcinoma. Computed tomography should be the most sensitive meth...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::A 45-year-old patient with focal intrahepatic extramedullary hematopoiesis is presented in which the liver was imaged by CT, ultrasound, and MR. The appearance of the lesions on MR consisted of slightly increased signal on T2-weighted images with heterogeneous enhancement of some of the lesions during bolus infusion o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract::An enterogenous cyst of the craniocervical region producing anterior medullary compression is reported. The patient presented with quadriparesis with greater involvement of the upper limbs. Computed tomography showed a high attenuation intradural extramedullary mass located anteriorly. Magnetic resonance imaging demon...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199005000-00030
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the utility of a balloon rectal channel catheter (BRCC) in complex anal fistula magnetic resonance imaging (MRI). METHODS:A prospective study was done on 54 patients with clinical diagnosis of complex anal fistula. Eighteen patients had preoperative MRI before and aft...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000400
更新日期:2016-07-01 00:00:00
abstract::The magnetic resonance imaging (MRI) findings in 2 cases of ovarian cancer arising in an endometrioma are presented. In both cases, the cancer was evident as an enhancing mass within a blood-filled adnexal cyst. The MRI findings of an enhancing mass within a blood-filled adnexal cyst should prompt consideration of ova...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200411000-00018
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Fatty infiltration in the rotator cuff muscles has been well studied in the setting of rotator cuff tendon tears to help predict outcomes of surgical repair. Fatty infiltration in the rotator cuff has also been independently correlated to the variables of age and sex. The purpose of our study was to determine...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000672
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Phase-contrast cine magnetic resonance imaging (PC-MRI) is a widely used technique for determination of possible communication of arachnoid cysts (ACs). Three-dimensional (3D) sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-SPACE) technique is a relatively new ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000751
更新日期:2018-09-01 00:00:00
abstract::In a case of cerebral infarction the lesions were isointense to slightly hyperintense in the T2-weighted MR images obtained approximately 2 weeks after the onset. Earlier (1 week after onset), they had been markedly hyperintense. The probably mechanisms behind this phenomenon, referred to as "MR fogging" are discussed...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199101000-00029
更新日期:1991-01-01 00:00:00