Abstract:
:We previously reported generalized cerebral glucose hypometabolism in amyotrophic lateral sclerosis (ALS) patients with upper motor neuron disease, using positron emission tomography (PET) with [18F]2-fluoro-2-deoxy-D-glucose. The present article presents a more detailed regional analysis of the hypometabolism, including measurements of the motor-sensory cortex at higher levels than used earlier. The analysis is based on 19 PET studies of 12 patients with ALS, four of whom had only lower motor neuron involvement, and 11 studies of age-matched control subjects. A brain size correction was included to eliminate differences in metabolism related to brain size but not to pathology. The eight ALS patients with both upper and lower motor neuron disease showed generalized hypometabolism, compared with the normal control subjects, that was greatest in the motor-sensory cortex and putamen. The motor-sensory deficit was strongly correlated with length of disease, and a marked sequential reduction was seen in repeat studies on four of the patients. There was also significant right-left asymmetry in these scans. No cerebral hypometabolism was seen in the four ALS patients without upper motor neuron involvement. Although the observed motor-sensory deficit in ALS is consistent with histopathological findings, the more generalized hypometabolism and the asymmetry suggest more widespread effects.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Hatazawa J,Brooks RA,Dalakas MC,Mansi L,Di Chiro Gdoi
10.1097/00004728-198807000-00019subject
Has Abstractpub_date
1988-07-01 00:00:00pages
630-6issue
4eissn
0363-8715issn
1532-3145journal_volume
12pub_type
杂志文章abstract:OBJECTIVES:To retrospectively determine, by using multislice computed tomography (MSCT), whether additional interpretation of sliding-thin-slab maximum-intensity projection (MIP) reformation images improve diagnostic accuracy when compared with the diagnostic interpretation of conventional sliding-thin-slab multiplanar...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31815ba1cd
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The water component dominates in in vivo proton (1H) spectroscopy. This consists of a prominent central peak with large "wings," and consequently metabolites that lie on the "wings" become difficult to quantitate. A method has been developed to deconvolve the water component in in vivo 1H spectroscopy, hence ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199509000-00030
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of test injection technique using a monitoring scan at knee level for 64-slice multidetector row computed tomographic (MDCT) angiography of the abdominal and lower extremity arteries. METHODS:The test injection technique using low-dose serial CT scan at knee level was performed for ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181674063
更新日期:2009-01-01 00:00:00
abstract::This is the third of a series of 4 white papers that represent Expert Consensus Documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its Task Force on dual-energy computed tomography. This paper, part 3, describes computed tomography angiography and thoracic, cardiac, vascular,...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000538
更新日期:2017-01-01 00:00:00
abstract::We obtained diffusion-weighted echo planar images of the human cervical cord in vivo and correlated them with histopathologic findings. Images were obtained in 17 healthy volunteers using a 1.5 T clinical MR unit. When motion-probing gradients were added perpendicular to the long axis of the cord, the white matter was...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200005000-00023
更新日期:2000-05-01 00:00:00
abstract::The computed tomographic (CT) appearance of global infarction of the kidney has not been previously reported. We report a clinically proven case as well as two other cases with clinical and radiographic findings consistent with renal infarction. The CT appearance of global renal infarction corresponds with its convent...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198112000-00011
更新日期:1981-12-01 00:00:00
abstract::The orbital lesions in six patients with Wegener's granulomatosis were studied by computer assisted tomography (CAT). Four patients had active orbital disease and proptosis, and each was found to have orbital masses accompanied by varying degrees of bone and sinus destruction. Two additional patients with histories of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197801000-00006
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:Our goal was to characterize the MR features of pathologically documented gliosarcoma and to determine if these features help differentiate gliosarcoma from other intracranial neoplasms. METHOD:MR studies of six patients with pathologically documented gliosarcoma were retrospectively analyzed. RESULTS:The tum...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199609000-00006
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to evaluate the effect of heart rate on exposure window, best phase, and image quality for stress computed tomography perfusion (CTP) in the CORE320 study. METHODS:The CTP data sets were analyzed to determine the best phase for perfusion analysis. A predefined exposure window coveri...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究
doi:10.1097/RCT.0000000000000514
更新日期:2017-03-01 00:00:00
abstract::Fast MR techniques and the application of water-soluble contrast agents allow the simultaneous examination of renal morphology and the functional aspects of glomerular filtration using bolus injections of Gd-DTPA. Spatial resolution is sufficient to resolve individual renal pyramids, but the quantitative examination o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199109000-00002
更新日期:1991-09-01 00:00:00
abstract::Pneumatosis cystoides coli (PCC) is an uncommon condition in which multiple gas-filled cysts in the walls of the colon. Patients with PCC initially complain of various symptoms including abdominal discomfort, constipation, diarrhea, hematochezia, vomiting, and fever. We recently diagnosed PCC by computed tomography (C...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/rct.0b013e31805d08ca
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Fatty infiltration in the rotator cuff muscles has been well studied in the setting of rotator cuff tendon tears to help predict outcomes of surgical repair. Fatty infiltration in the rotator cuff has also been independently correlated to the variables of age and sex. The purpose of our study was to determine...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000672
更新日期:2018-03-01 00:00:00
abstract::We review our preliminary experience with the use of three-dimensional (3D) time-of-flight (TOF) magnetic resonance (MR) angiography (MRA) in the assessment of intra- and extracranial aneurysms. Six patients were examined: Five had intracranial aneurysms and one had a cervical carotid pseudoaneurysm. A 3D rephased gra...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199011000-00002
更新日期:1990-11-01 00:00:00
abstract::Pancreas transplantation has become more commonplace over the past several decades. Consequently, the radiological evaluation of patients with such transplants has also become more common. Radiologists must therefore be familiar with the normal imaging appearances of pancreas transplant grafts as well as a wide variet...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0b013e3181966988
更新日期:2009-07-01 00:00:00
abstract::Two patients with phenylketonuria are reported with white matter lesions. Diffusion magnetic resonance (MR) imaging revealed restricted diffusion patterns (high signal) on b = 1000 s/mm2 images associated with low apparent diffusion coefficient values ranging between 0.44 x 10-3 mm2/s and 0.56 x 10-3 mm2/s. On proton ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200307000-00016
更新日期:2003-07-01 00:00:00
abstract::There is disagreement about the ability of CT to detect isolated invasion of mediastinal vessels by malignant thymoma. Diagnosis usually depends on the absence of intact fat planes between the tumor mass and the adjacent vessel. We describe a rare case of CT demonstration of direct intraluminal invasion of a malignant...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198903000-00035
更新日期:1989-03-01 00:00:00
abstract::A test method with use of a biologic phantom--a deep-frozen specimen of a human cadaver--was developed in an attempt to simulate the clinical setting in CT of the spine. The quality of both soft tissue and bone images in the absence of motion artifacts was evaluated for seven scanner models. Special attention was paid...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198611000-00023
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:Our goal was to examine regional preservation of energy metabolism in Alzheimer disease (AD) and to evaluate effects of PET data normalization to reference regions. MATERIALS AND METHODS:Regional metabolic rates in the pons, thalamus, putamen, sensorimotor cortex, visual cortex, and cerebellum (reference reg...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199507000-00006
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the magnetic resonance imaging findings of decidualized endometriotic cysts in comparison with endometriotic cysts associated with ovarian cancers. METHODS:Eighteen decidualized endometriotic cysts and 24 ovarian cancers were retrospectively assessed on height, signa...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000136
更新日期:2014-11-01 00:00:00
abstract::Pulmonary vein stenosis is one of the frequent complications after radiofrequency ablation for atrial fibrillation. MRI plays an important role in depicting the pathoanatomic structure of the pulmonary veins, and measuring the blood flow velocity in the pulmonary veins before and after therapy, and is superior to tran...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200101000-00006
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Prior work has described the relationship between pulmonary vascular pruning on computed tomography (CT) scans and metrics of right-sided heart dysfunction in smokers. In this analysis, we sought to look at pruning on a lobar level, as well as examine the effect of the arterial and venous circulation on this ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000465
更新日期:2016-11-01 00:00:00
abstract::A patient with a pancreatic body and tail mass caused by Castleman disease and visible on computed tomography is described. This entity simulated pancreatic carcinoma in this clinical setting. Theories of etiology of Castleman disease and differential diagnosis of pancreatic masses are discussed. Proper examination te...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198212000-00027
更新日期:1982-12-01 00:00:00
abstract:INTRODUCTION:Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. MAT...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000262
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To describe the thin-section computed tomography (CT) findings of Sjogren syndrome accompanying pulmonary amyloidosis and lymphoproliferative disease and to compare these with histopathologic findings. SUBJECTS AND METHODS:The thin-section CT findings of 5 women (age range: 42-59 years, mean age=50 years) wi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200411000-00008
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:We compared MRI with two-dimensional echocardiography (2dE) and Doppler echocardiography to determine the diagnostic role of MRI in hypertrophic cardiomyopathy (HCM). MATERIALS AND METHODS:Twenty-three patients with 2dE diagnosis of HCM were examined with MRI; 12 of 23 patients were also studied by color (cD...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199311000-00005
更新日期:1993-11-01 00:00:00
abstract::An enterogenous cyst of the craniocervical region producing anterior medullary compression is reported. The patient presented with quadriparesis with greater involvement of the upper limbs. Computed tomography showed a high attenuation intradural extramedullary mass located anteriorly. Magnetic resonance imaging demon...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199005000-00030
更新日期:1990-05-01 00:00:00
abstract::Although tuberculosis is an uncommon cause of spinal arachnoiditis, it needs to be differentiated from other causes of arachnoiditis because it is a treatable disease. Myelography, which is the imaging modality of choice for the chronic adhesive stage of tuberculous arachnoiditis, usually reveals irregularity of the t...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199301000-00023
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:We assessed the accuracy of coronary computed tomography angiography (CTA) in patients with an Agatston calcium score (ACS) of greater than 400 by comparing it with invasive coronary angiography (ICA), and we evaluated the predictive value of CTA for obstructive coronary heart disease (CHD) compared with tradit...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e318282d61c
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:The purpose of this work was to evaluate the radiologic findings of gastrointestinal (GI) tract involvement in hepatocellular carcinoma (HCC) and to discuss mechanisms of spread. METHOD:Eighteen patients with histologically proven GI tract metastasis in HCC for 4.5 years underwent CT and five also underwent up...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200201000-00014
更新日期:2002-01-01 00:00:00
abstract::The aim of this review was to review the basic background, technique, and clinical applications of arterial spin labeling in brain tumors. Arterial spin labeling is used for differentiation of brain tumors from nonneoplastic lesions such as infarction and infection. It has a role in the grading of gliomas and in the d...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000000873
更新日期:2019-07-01 00:00:00