Abstract:
OBJECTIVE:Our goal was to examine regional preservation of energy metabolism in Alzheimer disease (AD) and to evaluate effects of PET data normalization to reference regions. MATERIALS AND METHODS:Regional metabolic rates in the pons, thalamus, putamen, sensorimotor cortex, visual cortex, and cerebellum (reference regions) were determined stereotaxically and examined in 37 patients with probable AD and 22 normal controls based on quantitative 18FDG-PET measurements. Following normalization of metabolic rates of the parietotemporal association cortex and whole brain to each reference region, distinctions of the two groups were assessed. RESULTS:The pons showed the best preservation of glucose metabolism in AD. Other reference regions showed relatively preserved metabolism compared with the parietotemporal association cortex and whole brain, but had significant metabolic reduction. Data normalization to the pons not only enhanced statistical significance of metabolic reduction in the parietotemporal association cortex, but also preserved the presence of global cerebral metabolic reduction indicated in analysis of the quantitative data. CONCLUSION:Energy metabolism in the pons in probable AD is well preserved. The pons is a reliable reference for data normalization and will enhance diagnostic accuracy and efficiency of quantitative and nonquantitative functional brain imaging.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Minoshima S,Frey KA,Foster NL,Kuhl DEdoi
10.1097/00004728-199507000-00006subject
Has Abstractpub_date
1995-07-01 00:00:00pages
541-7issue
4eissn
0363-8715issn
1532-3145journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:This cross-sectional study assessed the prognostic implications of computed tomography (CT) coronary artery calcification (CAC), independent of emphysema, in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS:Coronary artery calcification and emphysema were assessed on noncontr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000119
更新日期:2014-09-01 00:00:00
abstract::Prenatal diagnosis of monoamnionicity is necessary for optimal care of a twin gestation. When the fetuses are discordant for a lethal anomaly, unequivocal confirmation is imperative. Ultrasound evaluation of our patient revealed a twin gestation discordant for anencephaly and with possible monoamnionicity. When sonogr...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199401000-00034
更新日期:1994-01-01 00:00:00
abstract::We describe a patient with a metastatic liver tumor that showed a cordlike shadow traversing the tumor on CT. Histopathologically, this cordlike shadow within the metastatic liver tumor was proved to be an infiltrated portal vein without blood flow surrounded by fibrous tissue. Vascular structures traversing a focal l...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199501000-00026
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To verify the earliest detectability of liver metastases in patients who underwent serial multidetector computed tomography (MDCT) examinations. METHODS:We selected 12 patients with known primary cancer who underwent 4 or more contrast-enhanced, 4-detector MDCTs. When metastases had been reported, an evaluat...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200605000-00006
更新日期:2006-05-01 00:00:00
abstract::The demonstration by computed tomography (CT) of enlarged nodes and/or masses in lymphoma patients has been interpreted as indicating that active disease is present. Four cases are presented in which either biopsy or laparotomy of a CT-detected mass after therapy revealed fibrous tissue with no evidence of viable neop...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198208000-00025
更新日期:1982-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare quantitative and qualitative measures of aortic, cardiac, and respiratory motion artifact between high-pitch dual-source (DS) and single-source (SS) computed tomography pulmonary angiography (CTPA) protocols. METHODS:This institutional review board-approved, Health Insu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000736
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:We compared body coil (BC) MR images and endorectal surface coil (ERC) images with respect to the visualization of the cervix and adjacent tissues and the histopathologic correlations of the imaging findings. MATERIALS AND METHODS:Twenty-one patients with cervical carcinoma underwent MRI using both coils for...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Renal pseudotumors may be intrinsic or extrinsic to the renal parenchyma. A case in which an ectopic position of the pancreatic tail simulated a solid left renal mass on nephrotomography and ultrasonography is presented. Computed tomography was important in confirming the etiology of the mass. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198308000-00030
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:Optic nerve glioma is a common finding in patients with neurofibromatosis type 1 (NF-1). Although dural ectasia of the optic nerve is encountered rarely, it has to be considered in the differential diagnosis. MATERIALS AND METHODS:Three patients affected by NF-1 were examined sequentially by CT and MRI. RES...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199409000-00009
更新日期:1994-09-01 00:00:00
abstract::Spiral CT (SCT) differs from conventional CT in that the entire heart can be rapidly imaged in the axial plane following the peripheral infusion of small quantities of contrast material. As contrast material travels through coronary artery bypass graft segments, good image detail is achieved, allowing visualization of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199303000-00014
更新日期:1993-03-01 00:00:00
abstract::The magnetic resonance appearance of three lesions of focal nodular hyperplasia observed in two patients is reviewed. All three lesions demonstrated isointensity with the liver on the short repetition time (TR) and echo time (TE) spin echo images. One lesion also showed a central area of low signal intensity that path...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198707000-00019
更新日期:1987-07-01 00:00:00
abstract::The CT appearance of hemiazygos continuation of a left-sided inferior vena cava is presented along with discussion of associated anomalies. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198803000-00027
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to develop a software program that calculates bone cross-sectional area (CSA) and moments of inertia from digital images, test the computations for accuracy, and implement the software in a study of longitudinal changes in bone properties in a large group of postmenopausal wo...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199407000-00021
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to assess the value of dual-head gamma-camera (DHGC) imaging in the coincidence mode using 2-[18F]-fluoro-2-deoxy-D-glucose in differentiating recurrent tumor from posttreatment changes in previously treated head and neck cancer. METHODS:This was a single-center prospective s...
journal_title:Journal of computer assisted tomography
pub_type: 临床试验,杂志文章
doi:10.1097/01.rct.0000164673.41885.4d
更新日期:2005-07-01 00:00:00
abstract::Computed tomography (CT) has enabled noninvasive evaluation of coronary bypass graft patency. Thirty-three patients operated on with 75 venous coronary bypass grafts were studied in the early postoperative period. Scans were taken with geometric magnification with a field of view of 16 or 24 cm, which gave a high spat...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198112000-00006
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:To evaluate stent-induced artifacts by 64-row multidetector computed tomography (MDCT). METHODS:We studied 26 stented patients with MDCT before conventional coronary angiography (CCA). The CT values were measured. Stents were classified as occluded, with significant stenosis, with nonsignificant stenosis, or...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181ddbbc0
更新日期:2010-11-01 00:00:00
abstract::To evaluate the performance of our elastic matching system, we have created a digitized atlas from the brain of a normal young man, using 135 myelin-stained sections at 700 microns spacing. Software was written to enter and edit regional anatomic contours, which were stacked and aligned to create a three-dimensional a...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198907000-00009
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVES:Pelvic organ prolapse is a common debilitating condition affecting women. Cross-sectional imaging with magnetic resonance imaging (MRI) depicts pelvic floor anatomy as well as organ prolapse and can complement or replace fluoroscopy. Occasionally, patients cannot tolerate MRI, but multiplanar visualization o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200309000-00016
更新日期:2003-09-01 00:00:00
abstract::Mucinous cystadenocarcinoma (MCA) is a rare tumor that is considered to be a cystic variant of mucin-producing lung adenocarcinoma. MCA expands grossly by storing mucus and contains few neoplastic cells. We present the CT images of three patients with MCA and correlate them with pathologic specimens. The CT findings o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199907000-00028
更新日期:1999-07-01 00:00:00
abstract::A method is outlined for obtaining direct longitudinal computed tomograms of the forearm using a conventional total body scanner. A case is described in which longitudinal scanning helped define a soft tissue tumor of the forearm and thereby assisted in surgical planning. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198102000-00029
更新日期:1981-02-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the effectiveness and additive value of T2W 3-dimensional sampling perfection with application optimized contrast (3D-SPACE) with variant flip-angle mode in imaging of all types of hydrocephalus. Our secondary objective was to assess the reliability of 3D-SPACE sequence and corre...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000206
更新日期:2015-05-01 00:00:00
abstract::We describe the case of a 50-year-old man with history of remote splenectomy who underwent routine lung cancer screening chest computed tomography and was incidentally found to have a liver lesion. Dedicated liver protocol computed tomography demonstrated "archiform" enhancement pattern in the arterial phase and homog...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000762
更新日期:2018-09-01 00:00:00
abstract::Extraskeletal spread of multiple myeloma is common and may cause jaundice due to hepatic infiltration. Less commonly, involvement of the pancreas may cause obstructive jaundice. We present a patient with multiple myeloma who became jaundiced. Computed tomography revealed an obstructing pancreatic mass. Aspiration biop...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::The value of the angio-computed tomography technique for evaluating communication between cardiac cavities of the two hearts in conjoined twins is reported. After injecting contrast medium into the peripheral vein of one of the twins, the increase in density values of the heart in the other twin suggested shunting bet...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198108000-00023
更新日期:1981-08-01 00:00:00
abstract::Melorheostosis is a rare benign disease of cortical bone most frequently presenting as peripheral hyperostosis with a characteristic "melting wax" appearance on conventional radiographs. The disease most frequently affects the appendicular skeleton and is seen only rarely in the craniofacial bones. We discuss a case o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3181572998
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate a prototype, ultrahigh-resolution computed tomography offering higher reconstruction matrix (1024 × 1024) and spatial resolution (0.15 mm) for chest imaging. METHODS:Higher (1024) matrix reconstruction enabled by ultrahigh-resolution computed tomography scanner (12...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000917
更新日期:2019-09-01 00:00:00
abstract::Quantitation of regional myocardial blood flow (MBF) in absolute terms with positron emission tomography (PET) has been difficult to achieve in part because of errors induced by the relatively low spatial resolution of current tomographic instruments. We previously demonstrated that MBF could be accurately measured ov...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198909000-00021
更新日期:1989-09-01 00:00:00
abstract::In a consecutive group of 1,067 noncholecystectomized patients referred for computed tomography including the upper abdomen, gallstones were seen in 13%. In 4% of the patients with gallstones, gas-containing calculi were found. On reviewing the conventional plain films such stones were revealed in less than one-half o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00009
更新日期:1983-10-01 00:00:00
abstract::Cooperative patients can often keep still during a long examination of the brain provided that they are given cues about their position in space. In a U-shaped head support, the only movements likely are rotation in the sagittal or transverse planes. These can be detected by a nasal orientation device (NOD), simply a ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199001000-00038
更新日期:1990-01-01 00:00:00
abstract::The purpose of this 4-part series is to demonstrate the high-resolution axial and coronal anatomy of temporal bone from a flat-panel detector-based volume computed tomography (CT) scanner (parts I and II); these imaging planes are then used to outline the effect of different surgical procedures commonly applied to the...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000171239.18301.96
更新日期:2005-07-01 00:00:00