Computed Tomography Assessment of Ablation Zone Enhancement in Patients With Early-Stage Lung Cancer After Stereotactic Ablative Radiotherapy.

Abstract:

INTRODUCTION:Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. MATERIALS AND METHODS:In this retrospective designed Institutional Review Board-approved study, follow-up contrast-enhanced computed tomography (CT) exams were performed on sixty one patients to evaluate enhancement pattern in the ablation zone at 1, 3, 6, and 12 months after SABR. RESULTS:Eleven patients had recurrence within the ablation zone after SABR. The postcontrast enhancement in the recurrence group showed a washin and washout phenomenon, whereas the radiation-induced lung injury group showed continuous enhancement suggesting an inflammatory process. CONCLUSIONS:The textural feature of the ablation zone of enhancement and perfusion as demonstrated in computed tomography nodule enhancement may allow early differentiation of recurrence from radiation-induced lung injury in patients' status after SABR or primary lung cancer.

journal_name

J Comput Assist Tomogr

authors

Moore W,Chaya Y,Chaudhry A,Depasquale B,Glass S,Lee S,Shin J,Mikhail G,Bhattacharji P,Kim B,Bilfinger T

doi

10.1097/RCT.0000000000000262

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

804-9

issue

5

eissn

0363-8715

issn

1532-3145

journal_volume

39

pub_type

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