Vitamin D as a marker of cognitive decline in elderly Indian population.

Abstract:

OBJECTIVES:Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. MATERIALS AND METHODS:The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done. RESULTS:Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls. CONCLUSION:Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.

journal_name

Ann Indian Acad Neurol

authors

Vedak TK,Ganwir V,Shah AB,Pinto C,Lele VR,Subramanyam A,Shah H,Deo SS

doi

10.4103/0972-2327.160052

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

314-9

issue

3

eissn

0972-2327

issn

1998-3549

pii

AIAN-18-314

journal_volume

18

pub_type

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