Abstract:
Background and Aims:Intracranial atherosclerotic disease (ICAD) is common in the Asian population, but less studied in South Asians compared to East Asians. We compared risk factors, treatments, and outcomes among consecutive patients with symptomatic ICAD from India with a mixed-ethnic cohort from Chicago, Illinois. Methods:Consecutive patients with symptomatic ICAD were enrolled at 2 academic medical centers in Kerala, India and Chicago, United States. Data on demographics, risk factors, initial stroke severity (National Institute of Health Stroke Scale score [NIHSS]), recurrent stroke, and 3-month functional outcome (modified Rankin Scale [mRS]) were prospectively collected. Recurrent stroke was defined as symptomatic recurrence of focal neurologic deficits associated with radiographic evidence of new cerebral infarction within 3 months of index admission. Results:329 patients (117 from Kerala, 212 from Chicago) were included. Indian patients were younger (61 vs. 68, P < 0.001), less frequently had prior stroke history (15.4 vs. 32.5%, P = 0.001) and coronary artery disease (11.1 vs. 22.2%, P = 0.013) but had higher initial NIHSS score (median 6 vs. 3, P < 0.001). Both groups received reperfusion therapy in similar proportions (8.5 vs. 7.1%, P = 0.630) but at discharge, 90.6% of Indian patients compared to 59.0% of Chicago patients were treated with dual antiplatelet therapy. More recurrent strokes occurred in Chicago patients (21.7 vs. 1.9%, P < 0.001) but functional outcome did not differ significantly. Conclusion:Compared to patients in US with symptomatic ICAD, Indian patients were younger and had more severe strokes. However, Indian patients had lower rates of recurrent stroke, perhaps due to greater use of dual antiplatelet therapy.
journal_name
Ann Indian Acad Neuroljournal_title
Annals of Indian Academy of Neurologyauthors
Saraf U,Prabhakaran S,Arun K,Babiker A,Rajendran A,Kesavadas C,Sylaja PNdoi
10.4103/aian.AIAN_549_19subject
Has Abstractpub_date
2020-05-01 00:00:00pages
265-269issue
3eissn
0972-2327issn
1998-3549pii
AIAN-23-265journal_volume
23pub_type
杂志文章abstract::We describe a case of pediatric neuromyelitis optica (NMO) with muscle and lung involvement in addition to central nervous system disease. Our patient initially presented with features of area postrema syndrome, then subsequently with optic neuritis. The patient also had recurrent hyperCKemia that responded to cortico...
journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.164830
更新日期:2015-09-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.176866
更新日期:2016-04-01 00:00:00
abstract::[This corrects the article on p. 49 in vol. 18, PMID: 25745311.]. ...
journal_title:Annals of Indian Academy of Neurology
pub_type: 已发布勘误
doi:10.4103/0972-2327.162306
更新日期:2015-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.160052
更新日期:2015-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.93273
更新日期:2012-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.61280
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/aian.AIAN_298_18
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.58277
更新日期:2009-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章,评审
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.82808
更新日期:2011-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.138525
更新日期:2014-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章,评审
doi:10.4103/0972-2327.192886
更新日期:2016-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.107690
更新日期:2013-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.64645
更新日期:2010-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 社论
doi:10.4103/aian.AIAN_478_19
更新日期:2020-03-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.112494
更新日期:2013-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.74185
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.175437
更新日期:2016-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.91935
更新日期:2011-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.85889
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_44_17
更新日期:2017-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_158_17
更新日期:2017-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.120449
更新日期:2013-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.99728
更新日期:2012-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_434_19
更新日期:2020-03-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.42933
更新日期:2008-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.40227
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/aian.AIAN_126_18
更新日期:2019-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.176861
更新日期:2016-04-01 00:00:00