Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy.

Abstract:

:A 60-year-old male with chronic lymphatic leukemia (CLL) after 6 months of fludarabine therapy was admitted with status epilepticus and developed left hemiplegia. His magnetic resonance imaging revealed multiple T2 hyperintense lesions in the right frontal and left parieto-occipital lesion, simulating progressive multifocal leucoencephalopathy (PML). Cerebrospinal fluid Polymerase Chain Reaction (PCR) for JC virus was negative. We suggest the possible role of fludarabine in producing PML-like lesions in patients with Chronic Lymphocytic Leukemia (CLL).

journal_name

Ann Indian Acad Neurol

authors

Kalita J,Patel NS,Misra UK

doi

10.4103/0972-2327.41880

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

114-5

issue

2

eissn

0972-2327

issn

1998-3549

journal_volume

11

pub_type

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