Predictors of Outcome in Children with Status Epilepticus during Resuscitation in Pediatric Emergency Department: A Retrospective Observational Study.

Abstract:

OBJECTIVES:To study the clinical profile and predictors of outcome in children with status epilepticus (SE) during resuscitation in pediatric emergency department. MATERIALS AND METHODS:This retrospective study was carried out in a tertiary care teaching hospital. Admission and resuscitation data of children, aged between 1 month and 12 years, treated for SE, between September 2013 and August 2014, were extracted using a standard data collection form. Our SE management protocol had employed a modified pediatric assessment triangle to recognize and treat acute respiratory failure, cardiovascular dysfunction (CD), and subtle SE until all parameters resolved. Continuous positive airway pressure, fluid boluses based on shock etiology, inotropes, and cardiac safe anticonvulsants were the other modifications. Risk factors predicting mortality during resuscitation were analyzed using univariate and penalized logistic regression. RESULTS:Among 610 who were enrolled, 582 (95.4%) survived and 28 (4.6%) succumbed. Grunt odds ratio (OR): 3.747 (95% confidence interval [CI]: 1.035-13.560), retractions OR: 2.429 (95% CI: 1.036-5.698), rales OR: 10.145 (95% CI: 4.027-25.560), prolonged capillary refill time OR: 3.352 (95% CI: 1.339-8.388), and shock requiring >60 mL/kg fluids OR: 2.439 (95% CI 1.040-5.721) were associated with 2-3 times rise in mortality. Inappropriate prehospital treatment and CD were the significant predictors of mortality OR: 7.82 (95% CI 2.10-29.06) and 738.71 (95% CI: 97.11-999), respectively. Resolution of CD was associated with improved survival OR: 0.02 (95% CI: 0.003-0.17). CONCLUSION:Appropriate prehospital management and treatment protocol targeting resolution of CD during resuscitation could reduce mortality in children with SE.

journal_name

Ann Indian Acad Neurol

authors

Santhanam I,Yoganathan S,Sivakumar VA,Ramakrishnamurugan R,Sathish S,Thandavarayan M

doi

10.4103/aian.AIAN_369_16

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

142-148

issue

2

eissn

0972-2327

issn

1998-3549

pii

AIAN-20-142

journal_volume

20

pub_type

杂志文章
  • Epidemiological Survey of Neurological Diseases in a Tribal Population Cluster in Gujarat.

    abstract:Background:There are few community-based neuroepidemiological studies based in tribal communities. This cross-sectional community-based study explored the prevalence rates of neurological disorders in the tribal region of Kaparada in Gujarat. Methodology:A two-stage methodology was used. Door-to-door surveys were cond...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_284_18

    authors: Mansukhani KA,Barretto MA,Donde SA,Wandrekar J,Nigudkar A,Nair R

    更新日期:2018-10-01 00:00:00

  • Study to assess the effectiveness of modified constraint-induced movement therapy in stroke subjects: A randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to assess the effectiveness of modified constraint induced movement therapy (m-CIMT) in stroke subjects. MATERIALS AND METHODS:A total of forty sub-acute stroke subjects were randomly assigned to either a m-CIMT (n = 20) or in a control group (n = 20). The m-CIMT gr...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.112461

    authors: Singh P,Pradhan B

    更新日期:2013-04-01 00:00:00

  • Primary Sjögren's syndrome manifesting as multiple cranial neuropathies: MRI findings.

    abstract::We report a case of primary Sjögren's syndrome presenting with multiple cranial nerve palsies and radiological evidence of cranial pachymeningitis and hypophysitis. A 47-year-old woman developed right sensory neural hearing loss followed, 2 months later, by right facial palsy. Cranial magnetic resonance imaging showed...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.53083

    authors: Ashraf VV,Bhasi R,Kumar RP,Girija AS

    更新日期:2009-04-01 00:00:00

  • The need for a population-based, dose optimization study for recombinant tissue plasminogen activator in acute ischemic stroke: A study from a tertiary care teaching hospital from South India.

    abstract:CONTEXT:The guideline recommended dose of intravenous (i.v) recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke is 0.9 mg/kg in the European and American populations. In Asiatic population, some studies have shown that a lower dose of i.v rt-PA is equally efficacious. AIMS:To assess if ther...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.199911

    authors: Abraham SV,Thaha F,Krishnan SV,Shajan A,Balakrishnan JM,Palatty BU

    更新日期:2017-01-01 00:00:00

  • Prevalence and association of lifestyle factors with extracranial carotid atherosclerosis in non-cardioembolic anterior circulation strokes in adult males less than 50 years: One year cross-sectional study.

    abstract:BACKGROUND:Data is scarce on prevalence of extracranial carotid atherosclerosis (ECA) in strokes <50 years and its association with lifestyle factors. OBJECTIVE:Study role of (a) ECA in non-cardio-embolic anterior circulation young strokes, and (b) smoking and alcohol in ECA. MATERIALS AND METHODS:Cardiovascular risk...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.120448

    authors: Hassan KM,Verma A,Prakash S,Chandran V,Kumar S,Banerji A

    更新日期:2013-10-01 00:00:00

  • Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene.

    abstract:BACKGROUND AND PURPOSE:Diagnostic evaluation of limb-girdle muscular dystrophy type 2A (LGMD2A) involves specialized studies on muscle biopsy and mutation analysis. Mutation screening is the gold standard for diagnosis but is difficult as the gene is large and multiple mutations are known. This study evaluates the util...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.175435

    authors: Khadilkar SV,Chaudhari CR,Dastur RS,Gaitonde PS,Yadav JG

    更新日期:2016-01-01 00:00:00

  • Report: Stem cell applications in neurological practice, an expert group consensus appraisal.

    abstract:INTRODUCTION:Neurologists in their clinical practice are faced with inquiries about the suitability of stem cell approaches by patients with a variety of acute and chronic (namely neurodegenerative) disorders. The challenge is to provide these patients with accurate information about the scope of stem cell use as well ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.186825

    authors: Devi MG,Sharma A,Mohanty S,Jain N,Verma K,Padma MV,Pal P,Chabbra HS,Khadilkar S,Prabhakar S,Singh G

    更新日期:2016-07-01 00:00:00

  • Surgery for drug-resistant focal epilepsy.

    abstract::During the colloquium on drug-resistant epilepsy (DRE) at National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore on August 16-18, 2013, a number of presentations were made on the surgically remediable lesional epilepsy syndromes, presurgical evaluation, surgical techniques, neuropathology of drug r...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.128693

    authors: Rao MB,Arivazhagan A,Sinha S,Bharath RD,Mahadevan A,Bhat M,Satishchandra P

    更新日期:2014-03-01 00:00:00

  • Rabies viral encephalitis with proable 25 year incubation period!

    abstract::We report a case of rabies viral encephalitis in a 48-year-old male with an unusually long incubation period, historically suspected to be more than 20 years. The case was referred for histological diagnosis following alleged medical negligence to the forensic department. The histology and immunocytochemical demonstra...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.99728

    authors: Shankar SK,Mahadevan A,Sapico SD,Ghodkirekar MS,Pinto RG,Madhusudana SN

    更新日期:2012-07-01 00:00:00

  • Rare ocular manifestation in a case of West Nile virus meningoencephalitis.

    abstract::West Nile Virus (WNV) is an arthropod-borne flavivirus, which causes flu-like illness and is sporadically associated with encephalitis. Transmission to humans occurs following a bite from an infected mosquito, which acquires the virus after feeding on dead birds. WNV meningoencephalitis is a rare infection with a neur...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.128564

    authors: Malhotra K,Ramanathan RS,Synowiec A,Rana S

    更新日期:2014-01-01 00:00:00

  • Kleine-Levin syndrome: Etiology, diagnosis, and treatment.

    abstract::Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Each episode is of brief duration varying from a week to 1-2 months and affected people a...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.74185

    authors: Ramdurg S

    更新日期:2010-10-01 00:00:00

  • End of Life and Palliative Care in Neurology: Does Autonomy Matter?

    abstract::The recent supreme court of India judgment on autonomy makes it necessary for all practicing neurologists to appraise themselves of the changing legal framework for End-of-Life decision-making in India. A pathway has been prescribed for advance care planning and medical futility decision-making. This is an evolving la...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_138_18

    authors: Gursahani R,Mani RK,Simha SN

    更新日期:2018-10-01 00:00:00

  • Multisystem involvement in neuromyelitis optica.

    abstract::We describe a case of pediatric neuromyelitis optica (NMO) with muscle and lung involvement in addition to central nervous system disease. Our patient initially presented with features of area postrema syndrome, then subsequently with optic neuritis. The patient also had recurrent hyperCKemia that responded to cortico...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.164830

    authors: Langille MM,Desai J

    更新日期:2015-09-01 00:00:00

  • Fazio Londe syndrome: A treatable disorder.

    abstract::Fazio Londe Syndrome is a rare neurological disorder presenting with progressive bulbar palsy with respiratory failure. Initially considered to have an unrelenting course, is now found to be due to mutations in the SLC52A3 gene which encodes the intestinal (hRFT2) riboflavin transporter in some children. We report an ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.144283

    authors: Varadarajan P,Thayanathi V,Pauline LC

    更新日期:2015-01-01 00:00:00

  • Newer Paradigms in Language Neurobiology.

    abstract::The field of language research has seen tremendous progress in the last two decades. Advances in neuro-imaging and stimulation mapping have changed the way we conceive the neural basis of speech and language processing. In the past, the Wernicke-Lichtheim model was the most influential model explaining the neuro-anato...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_487_20

    authors: Gupta A,Padma Srivastava MV

    更新日期:2020-09-01 00:00:00

  • Role of vascular endothelial growth factor and other growth factors in post-stroke recovery.

    abstract::Stroke is a major health problem world-wide and its burden has been rising in last few decades. Until now tissue plasminogen activator is only approved treatment for stroke. Angiogenesis plays a vital role for striatal neurogenesis after stroke. Administration of various growth factors in an early post ischemic phase,...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章,评审

    doi:10.4103/0972-2327.128519

    authors: Talwar T,Srivastava MV

    更新日期:2014-01-01 00:00:00

  • Vitamin-Responsive Movement Disorders in Children.

    abstract::Movement disorders in childhood comprise a heterogeneous group of conditions that lead to impairment of voluntary movement, abnormal postures, or inserted involuntary movements. Movement disorders in children are frequently caused by metabolic disorders, both inherited and acquired. Many of these respond to vitamin su...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_678_19

    authors: Sondhi V,Sharma S

    更新日期:2020-05-01 00:00:00

  • A Preventable Ataxia: Cerebrotendinous Xanthomatosis.

    abstract::Cerebrotendinous xanthomatosis is an autosomal recessive inborn error of metabolism that is an often missed but treatable cause of hereditary ataxia. We report a case of cerebrotendinous xanthomatosis (CTX) that was diagnosed only after the development of cognitive decline and adult onset ataxia in a 35-year-old man. ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/aian.AIAN_126_18

    authors: Shaji B,Srikumar B,Ramachandran D

    更新日期:2019-10-01 00:00:00

  • Coexistence of central nucleus, cores, and rods: Diagnostic relevance.

    abstract:BACKGROUND:Congenital myopathies (CMs) though considered distinct disorders, simultaneous occurrence of central nucleus, nemaline rods, and cores in the same biopsy are scarcely reported. OBJECTIVE:A retrospective reassessment of cases diagnosed as CMs to look for multiple pathologies missed, if any, during the initia...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.176861

    authors: Dhinakaran S,Kumar RS,Thakkar R,Narayanappa G

    更新日期:2016-04-01 00:00:00

  • Endocrine, metabolic, nutritional, and toxic disorders leading to dementia.

    abstract::One of the first steps toward the correct diagnosis of dementia is to segregate out the nondegenerative dementias from possible degenerative dementias. Nondegenerative dementias could be due to traumatic, endocrine, metabolic, nutritional, toxic, infective, and immunological causes. They could also be caused by tumors...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.74247

    authors: Ghosh A

    更新日期:2010-12-01 00:00:00

  • Sural sensory nerve action potential: A study in healthy Indian subjects.

    abstract:BACKGROUND:The sural sensory nerve action potential (SNAP) is an important electrodiagnostic study for suspected peripheral neuropathies. Incorrect technique and unavailability of reference data can lead to erroneous conclusions. OBJECTIVES:To establish reference data for sural SNAP in age-stratified healthy subjects ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.186786

    authors: Sreenivasan A,Mansukhani KA,Sharma A,Balakrishnan L

    更新日期:2016-07-01 00:00:00

  • Chronic relapsing inflammatory optic neuropathy.

    abstract::Chronic relapsing inflammatory optic neuropathy (CRION) is a recently described recurrent optic neuropathy which is steroid responsive. Several features distinguish this entity from optic neuritis associated with demyelinating disorders and connective tissue diseases. The severe degree of visual loss, persistence of p...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.61280

    authors: Saini M,Khurana D

    更新日期:2010-01-01 00:00:00

  • Optimization of antiplatelet/antithrombotic therapy for secondary stroke prevention.

    abstract::Role of antiplatelet therapy in secondary stroke prevention is of major significance. Antiplatelet agents predominantly in use are aspirin, clopidogrel, and combination regimes. The review focuses on the optimization of antiplatelet regimen based on evidence obtained from randomized-controlled trials, on different ant...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.61270

    authors: Srivastava P

    更新日期:2010-01-01 00:00:00

  • A clinician's dilemma: Sturge-Weber syndrome 'without facial nevus'!!

    abstract::Sturge-Weber syndrome (SWS) is a rare, sporadic neurocutaneous syndrome characterized by a classical triad of facial port wine nevus, ipsilateral leptomeningeal angiomatosis (LAM) and glaucoma. The incidence of SWS is 1/50,000 live births, although it is more often underreported. The incidence of SWS without facial ne...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.107725

    authors: Jagtap SA,Srinivas G,Radhakrishnan A,Harsha KJ

    更新日期:2013-01-01 00:00:00

  • Electrophysiological study in neuromuscular junction disorders.

    abstract::This review is on ultrastructure and subcellular physiology at normal and abnormal neuromuscular junctions. The clinical and electrophysiological findings in myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), congenital myasthenic syndromes, and botulinum intoxication are discussed. Single fiber electromyogr...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.107690

    authors: Cherian A,Baheti NN,Iype T

    更新日期:2013-01-01 00:00:00

  • Female Caregivers and Stroke Severity Determines Caregiver Stress in Stroke Patients.

    abstract:Background:Stroke is among the major causes of short- and long-term disability. This study aimed to understand the caregivers (CGs) stress in stroke survivors. Materials and Methods:A 22-item questionnaire was administered to 201 CGs of stroke survivors. The variables tested were physical and mental health, social sup...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_203_17

    authors: Menon B,Salini P,Habeeba K,Conjeevaram J,Munisusmitha K

    更新日期:2017-10-01 00:00:00

  • Nummular headache and pituitary lesion: A case report and literature review.

    abstract::Nummular headache (NH) is a newly categorized headache disorder characterized by a consistent clinicographics in each attack. Currently, it is considered as a primary headache disorder due to epicranial neuralgia but the pathomechanism is still unknown. We report a woman, whose recurrent NH subsided after trans-spheno...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.112475

    authors: Chui C,Chen WH,Yin HL

    更新日期:2013-04-01 00:00:00

  • Burden Faced by Caregivers of Stroke Patients Who Attend Rural-based Medical Teaching Hospital in Western India.

    abstract:Background:Stroke results in significant caregiver burden and strain. Objective:The main objectives of this study is to assess the burden and its consequences in caregivers of stroke patients and to determine the associated factors to caregivers' burden. Methods:A cross-sectional study was conducted over 1 year on 70...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_406_18

    authors: Mandowara B,Patel AN,Amin AA,Phatak A,Desai S

    更新日期:2020-01-01 00:00:00

  • Glutaric aciduria type I: A treatable neurometabolic disorder.

    abstract:BACKGROUND AND OBJECTIVES:Glutaric aciduria Type-I (GA-I) has characteristic clinical and neuroimaging features, which clinches the diagnosis in a majority of patients. However, there have been few case reports on GA-I from India. This study was undertaken to study the clinical presentations, metabolic profile, neuroim...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.93273

    authors: Kamate M,Patil V,Chetal V,Darak P,Hattiholi V

    更新日期:2012-01-01 00:00:00

  • Multiple sulfatase deficiency: A case series of four children.

    abstract::Multiple sulfatase deficiency is biochemically characterized by the accumulation of sulfated lipids and acid mucopolysaccharides. The gene sulfatase-modifying factor 1 (SUMF1), recently identified, encodes the enzyme responsible for post-translational modification of a cysteine residue, which is essential for the acti...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.120449

    authors: Incecik F,Ozbek MN,Gungor S,Pepe S,Herguner OM,Mungan NO,Gungor S,Altunbasak S

    更新日期:2013-10-01 00:00:00