Abstract:
:Neuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease. This article summarizes the major advances in neuromyelitis optica, particularly in the last 2 years, and supplements the previous review published in this Journal in 2007. Important among these developments are: the epidemiological studies, which have provided estimates of incidence and prevalence; identification of mutations in the aquaporin-4 gene; improved understanding of the effects of anti-aquaporin-4 antibody on astrocytes; roles of excitatory amino acid transporter type 2 and glutamate; requirement of aquaporin-4 to be in orthogonal arrays to be antigenic; recognition of the presence of aquaporin-4 antibody in patients with cancer and posterior reversible encephalopathy syndrome; possibility of monitoring the disease using the antibody, and the effectiveness of rituximab and mycophenolate in preventing relapses.
journal_name
Ann Indian Acad Neuroljournal_title
Annals of Indian Academy of Neurologyauthors
Jacob Adoi
10.4103/0972-2327.58277subject
Has Abstractpub_date
2009-10-01 00:00:00pages
231-7issue
4eissn
0972-2327issn
1998-3549journal_volume
12pub_type
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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pub_type: 已发布勘误
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journal_title:Annals of Indian Academy of Neurology
pub_type:
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更新日期:2013-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章,评审
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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更新日期:2012-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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更新日期:2008-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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更新日期:2012-10-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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