A case of late-onset allgrove syndrome presenting with predominant autonomic dysfunction.

Abstract:

:Allgrove Syndrome or triple A syndrome is a rare familial multisystem disorder characterized by achalasia, alacrima and adrenal insufficiency. The objective was to describe a case of 4A syndrome where autonomic dysfunction was the presenting feature. A 22-year-old male presented with erectile dysfunction and loss of spontaneous morning erections for six months. He was having nocturnal diarrhea and recurrent postural dizziness for three months. He was found to have hyperpigmentation at pressure points, postural hypotension and other features of autonomic dysfunction. Laboratory investigations and imaging studies revealed hypoadrenalism, achalasia, alacrima and peripheral neuropathy. Autonomic neuropathy-related features persisted even after correction of hypoadrenalism. Based on clinical features and investigation he was diagnosed as a case of 4A syndrome presenting with autonomic dysfunction. Allgrove or 4A syndrome should be considered as a rare differential diagnosis of someone presenting with features of autonomic neuropathy.

journal_name

Ann Indian Acad Neurol

authors

Sanyal D,Bhattacharjee S

doi

10.4103/0972-2327.112494

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

266-8

issue

2

eissn

0972-2327

issn

1998-3549

pii

AIAN-16-266

journal_volume

16

pub_type

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