Juvenile Myoclonic Epilepsy with Frontal Executive Dysfunction is Associated with Reduced Gray Matter Volume by Voxel-based Morphometry.


OBJECTIVE:Frontal executive dysfunction (FED) and abnormalities in volumetric magnetic resonance imaging (MRI) have been described in juvenile myoclonic epilepsy (JME). We aimed to compare JME patients with and without FED by group analysis of voxel-based morphometric (VBM) estimates of brain volume in MRI. SUBJECTS AND METHODS:We studied frontal executive functions in patients with JME and analyzed the possible association of FED with their demographic, clinical, and electrographic characteristics. We aimed to do group analysis of the VBM MRI brain data to compare the gray matter (GM) volumes of JME patients with and without FED. RESULTS:We recruited 34 patients (20 women) with JME (mean age 23.7 ± 4.58 years) from the epilepsy outpatient services. FED was detected in twenty patients (58.8%). Group analysis of VBM MRI brain showed significant (P < 0.001) reduction in GM volume in dorsolateral prefrontal cortex (left Brodmann area [BA] 10, 46, 9, Z-score 3.36, 2.91, 2.03, respectively, and right BA 10 and BA 45, Z-score 2.98 and 3.36, respectively), left insula (BA 13, Z-score 2.14), temporal lobe (BA 38, Z-score 2.76), in the subgroup of JME with FED. INFERENCE:JME with FED has an anatomical correlate in the form of reduced GM volume in dorsolateral prefrontal cortex.


Ann Indian Acad Neurol


Pillai SH,Raghavan S,Mathew M,Gopalan GM,Kesavadas C,Sarma S,Thomas SV




Has Abstract


2017-07-01 00:00:00














  • Predictors of Outcome in Children with Status Epilepticus during Resuscitation in Pediatric Emergency Department: A Retrospective Observational Study.

    abstract:OBJECTIVES:To study the clinical profile and predictors of outcome in children with status epilepticus (SE) during resuscitation in pediatric emergency department. MATERIALS AND METHODS:This retrospective study was carried out in a tertiary care teaching hospital. Admission and resuscitation data of children, aged bet...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Santhanam I,Yoganathan S,Sivakumar VA,Ramakrishnamurugan R,Sathish S,Thandavarayan M

    更新日期:2017-04-01 00:00:00

  • Dermatomyositis presenting with rhabdomyolysis and acute renal failure; an uncommon manifestation.

    abstract::Rhabdomyolysis and myoglobinuria are a rare complication of dermatomyositis. Such patient can land up in acute renal failure. Recognition of this fact has important therapeutic implications as patients require immunotherapy in addition to the symptomatic treatment for renal failure. We report a case of dermatomyositis...

    journal_title:Annals of Indian Academy of Neurology



    authors: Joshi D,Kumar N,Rai A

    更新日期:2009-01-01 00:00:00

  • Limb-girdle muscular dystrophy in the Agarwals: Utility of founder mutations in CAPN3 gene.

    abstract:BACKGROUND AND PURPOSE:Diagnostic evaluation of limb-girdle muscular dystrophy type 2A (LGMD2A) involves specialized studies on muscle biopsy and mutation analysis. Mutation screening is the gold standard for diagnosis but is difficult as the gene is large and multiple mutations are known. This study evaluates the util...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Khadilkar SV,Chaudhari CR,Dastur RS,Gaitonde PS,Yadav JG

    更新日期:2016-01-01 00:00:00

  • Multiple cerebral infarctions with severe multi-organ dysfunction following multiple wasp stings.

    abstract::Wasp and bee sting are commonly encountered worldwide. Local reactions are more common, generally are self-limiting and settle within a few hours. Multiple stings can lead to various clinical manifestations like vomiting, diarrhea, dyspnea, generalized edema, hypotension, syncope, acute renal failure, and even death. ...

    journal_title:Annals of Indian Academy of Neurology



    authors: Wani M,Saleem S,Verma S,Yousuf I,Wani M,Asimi R,Daga RA,Shah I,Aejaz

    更新日期:2014-01-01 00:00:00

  • Glutaric aciduria type I: A treatable neurometabolic disorder.

    abstract:BACKGROUND AND OBJECTIVES:Glutaric aciduria Type-I (GA-I) has characteristic clinical and neuroimaging features, which clinches the diagnosis in a majority of patients. However, there have been few case reports on GA-I from India. This study was undertaken to study the clinical presentations, metabolic profile, neuroim...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Kamate M,Patil V,Chetal V,Darak P,Hattiholi V

    更新日期:2012-01-01 00:00:00

  • Prevalence and Predictors of Female Sexual Dysfunction in Migraine.

    abstract:Background:Migraine is a common cause of primary headache, with women being affected thrice as common as men. Very few studies are available on sexual dysfunction in female migraineurs. There are no published studies done on the same in India till now. This study was done to look for the prevalence and predictors of se...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Pradeep R,Sundarmurthy H,Karan V,Kulkarni P

    更新日期:2019-07-01 00:00:00

  • Primary Sjögren's syndrome manifesting as multiple cranial neuropathies: MRI findings.

    abstract::We report a case of primary Sjögren's syndrome presenting with multiple cranial nerve palsies and radiological evidence of cranial pachymeningitis and hypophysitis. A 47-year-old woman developed right sensory neural hearing loss followed, 2 months later, by right facial palsy. Cranial magnetic resonance imaging showed...

    journal_title:Annals of Indian Academy of Neurology



    authors: Ashraf VV,Bhasi R,Kumar RP,Girija AS

    更新日期:2009-04-01 00:00:00

  • Role of vascular endothelial growth factor and other growth factors in post-stroke recovery.

    abstract::Stroke is a major health problem world-wide and its burden has been rising in last few decades. Until now tissue plasminogen activator is only approved treatment for stroke. Angiogenesis plays a vital role for striatal neurogenesis after stroke. Administration of various growth factors in an early post ischemic phase,...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章,评审


    authors: Talwar T,Srivastava MV

    更新日期:2014-01-01 00:00:00

  • Non-Motor Symptoms in Cervical Dystonia: A Review.

    abstract::Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive movements, postures, or both. Dystonic movements are typically patterned, associated with twisting of body parts, and may have tremulousness. Dystonia is usually initiated or worsened by vo...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Ray S,Pal PK,Yadav R

    更新日期:2020-07-01 00:00:00

  • Vitamin-Responsive Movement Disorders in Children.

    abstract::Movement disorders in childhood comprise a heterogeneous group of conditions that lead to impairment of voluntary movement, abnormal postures, or inserted involuntary movements. Movement disorders in children are frequently caused by metabolic disorders, both inherited and acquired. Many of these respond to vitamin su...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Sondhi V,Sharma S

    更新日期:2020-05-01 00:00:00

  • Prevalence and association of lifestyle factors with extracranial carotid atherosclerosis in non-cardioembolic anterior circulation strokes in adult males less than 50 years: One year cross-sectional study.

    abstract:BACKGROUND:Data is scarce on prevalence of extracranial carotid atherosclerosis (ECA) in strokes <50 years and its association with lifestyle factors. OBJECTIVE:Study role of (a) ECA in non-cardio-embolic anterior circulation young strokes, and (b) smoking and alcohol in ECA. MATERIALS AND METHODS:Cardiovascular risk...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Hassan KM,Verma A,Prakash S,Chandran V,Kumar S,Banerji A

    更新日期:2013-10-01 00:00:00

  • Necrotizing Autoimmune Myopathy: Clinicopathologic Study from a Single Tertiary Care Centre.

    abstract:Background:Idiopathic inflammatory myopathies (IIMs) are a group of chronic, autoimmune disorders which include a new entity, necrotizing autoimmune myopathy (NAM). NAM lacks inflammation and presents with markedly elevated creatinine phosphokinase (CPK) levels. It is associated with connective tissue diseases (CTDs), ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Ayesha SM,Meena AK,Vangala N,Rajasekhar L,Kaul S,Borgahain R,Uppin MS

    更新日期:2018-01-01 00:00:00

  • Nummular headache and pituitary lesion: A case report and literature review.

    abstract::Nummular headache (NH) is a newly categorized headache disorder characterized by a consistent clinicographics in each attack. Currently, it is considered as a primary headache disorder due to epicranial neuralgia but the pathomechanism is still unknown. We report a woman, whose recurrent NH subsided after trans-spheno...

    journal_title:Annals of Indian Academy of Neurology



    authors: Chui C,Chen WH,Yin HL

    更新日期:2013-04-01 00:00:00

  • "Missing clot" during mechanical thrombectomy in acute stroke using Solitaire stent retrieval system.

    abstract::Stent retrieval system is an established treatment modality in acute ischemic stroke with large vessel occlusion. Here, we describe a complication which occurred during mechanical thrombectomy in three cases where the clot dislodged during retrieval. There was a possibility of the clot getting reinjected into the arte...

    journal_title:Annals of Indian Academy of Neurology



    authors: Huded V,Nambiar V,De Souza R,Bohra V,Ramankutty R

    更新日期:2016-04-01 00:00:00

  • Therapeutic Efficacy of Plasma Exchange in Neuromyelitis Optica.

    abstract:Background:Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects the optic nerves and spinal cord and generally follows a relapsing course. Therapeutic plasma exchange (TPE) appears to be effective in patients with central nervous system inflammatory demyelinating disease who do n...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Kumar R,Paul BS,Singh G,Kaur A

    更新日期:2018-04-01 00:00:00

  • Stroke and skin rash: A rare case of Henoch-Schonlein purpura.

    abstract::Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is rare in adults. Here, we present a case of a woman who presented with palpable purpura, abdominal pain, arthritis and ischemic stroke. The patient met the diagnostic criteria of HSP. However, cerebrovascular disease is reported as an uncommon, yet fat...

    journal_title:Annals of Indian Academy of Neurology



    authors: Ghosh K,Chatterjee A,Sau JT,Dey S

    更新日期:2012-10-01 00:00:00

  • Anemia as a Predictor of Functional Disability in the Early Stage of Ischemic Stroke in a South Asian Population.

    abstract:Background:Reduced hemoglobin concentration has an adverse impact on the ischemic penumbra in patients with ischemic stroke as it causes reduced oxygen delivery to neuronal tissue and predisposes to infarct expansion. There is a paucity of data on the impact of anemia on early functional outcomes. Aims:To determine th...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Chang T,Weeratunga P,Vithanage T,Wijewickrama P,Kularathne S,Fernando S,Arambepola C

    更新日期:2020-07-01 00:00:00

  • Hyperacute Paraplegia and Neurovascular (Immuno Vasculotoxic) Catastrophe of Nicolau Syndrome: Primum Non nocere.

    abstract::A case of Nicolau syndrome (NS) in a 36-year-old adult taking an unusual and devastating hyperacute irreversible paraplegia after an intramuscular injection of benzathine penicillin as a part of routine chemoprophylaxis of her rheumatic heart disease is reported. Although this syndrome is a considerably rare, iatrogen...

    journal_title:Annals of Indian Academy of Neurology



    authors: Shelley BP,Prasad P,Manjunath MM,Chakraborti S

    更新日期:2019-01-01 00:00:00

  • De novo development of artistic creativity in Alzheimer's disease.

    abstract::The case of an 82-year-old female with probable Alzheimer's disease (AD), who developed unusual artistic creativity after development of her disease, is described. The possible pathogenetic mechanism is discussed. The patient showed no inclination toward visual arts during her premorbid years. However, 4 years after d...

    journal_title:Annals of Indian Academy of Neurology



    authors: Chakravarty A

    更新日期:2011-10-01 00:00:00

  • Spinal coning after lumbar puncture in a patient with undiagnosed giant cervical neurofibroma.

    abstract::Lumbar puncture in the presence of an intracranial tumor with raised intracranial pressure is known to have catastrophic consequences due to herniation of intracranial contents through the tentorial hiatus or foramen magnum. There are relatively few case reports about the same sequence of events when lumbar puncture i...

    journal_title:Annals of Indian Academy of Neurology



    authors: Krishnan P,Roychowdhury S

    更新日期:2013-07-01 00:00:00

  • Lhermitte's Sign: The Current Status.

    abstract::Lhermitte's sign was described by Marie and Chatelin and named after Jean Lhermitte. This sign is mostly described as an electric shock like condition by some patients of multiple sclerosis. This sensation occurs when the neck is moved in a wrong way or rather flexed. It can also travel down to the spine, arms, and le...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Khare S,Seth D

    更新日期:2015-04-01 00:00:00

  • Rabies viral encephalitis with proable 25 year incubation period!

    abstract::We report a case of rabies viral encephalitis in a 48-year-old male with an unusually long incubation period, historically suspected to be more than 20 years. The case was referred for histological diagnosis following alleged medical negligence to the forensic department. The histology and immunocytochemical demonstra...

    journal_title:Annals of Indian Academy of Neurology



    authors: Shankar SK,Mahadevan A,Sapico SD,Ghodkirekar MS,Pinto RG,Madhusudana SN

    更新日期:2012-07-01 00:00:00

  • Global workspace model of consciousness and its electromagnetic correlates.

    abstract::The global workspace of consciousness was proposed in its elementary framework by Baars, in 1982. Since the time of inception, there have been many speculations and modifications of this theory, but the central theme has remained the same, which refers to the global availability of information in the brain. However, t...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Prakash R,Prakash O,Prakash S,Abhishek P,Gandotra S

    更新日期:2008-07-01 00:00:00

  • Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis.

    abstract::We describe a young patient of acute transverse myelitis (ATM) who developed true lower motor neuron (LMN) type flaccid paraplegia as a result of anterior horn cell damage in the region of cord inflammation that extended from conus upwards up to the D4 transverse level. We infer that flaccidity in acute phase of ATM i...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Pradhan S,Kumar A

    更新日期:2014-07-01 00:00:00

  • Cardiac cephalalgia: First case from India.

    abstract::A 67-year-old male smoker had exertional headaches for 2 years. The headaches were holocephalic, very severe, excruciating, and occasionally accompanied by nausea. Physical examinations and neuroimaging were normal. Electrocardiogram (ECG) showed old infarct in inferior leads. Sublingual nitrate provided relief in hea...

    journal_title:Annals of Indian Academy of Neurology



    authors: Prakash S,Panchani N,Rathore C,Makwana P,Rathod M

    更新日期:2016-04-01 00:00:00

  • Effect of Distance between Marker Agreement Dependencies on Sentence Comprehension in Persons with Aphasia.

    abstract:Background:Rules and regularities are embedded in all the language structures. Extracting these helps in speech-language acquisition and processing. Sentence processing relies on transitional probability of the dependencies and its distance which are present within the sentence. Aim:To investigate the effect of distan...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Darshan HS,Goswami SP

    更新日期:2020-09-01 00:00:00

  • Epidemiological Survey of Neurological Diseases in a Tribal Population Cluster in Gujarat.

    abstract:Background:There are few community-based neuroepidemiological studies based in tribal communities. This cross-sectional community-based study explored the prevalence rates of neurological disorders in the tribal region of Kaparada in Gujarat. Methodology:A two-stage methodology was used. Door-to-door surveys were cond...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Mansukhani KA,Barretto MA,Donde SA,Wandrekar J,Nigudkar A,Nair R

    更新日期:2018-10-01 00:00:00

  • Duchenne/Becker muscular dystrophy: A report on clinical, biochemical, and genetic study in Gujarat population, India.

    abstract:OBJECTIVE:In India, various groups have studied different regions to find out deletion pattern of dystrophin gene. We have investigated its deletion pattern among Duchenne/Becker muscular dystrophy (D/BMD) patients across Gujarat. Moreover, in this study we also correlate the same with reading frame rule. However, we t...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Rao MV,Sindhav GM,Mehta JJ

    更新日期:2014-07-01 00:00:00

  • Erratum: Impulse control disorders and related behaviours (ICD-RBs) in Parkinson's disease patients: Assessment using "Questionnaire for impulsive-compulsive disorders in Parkinson's disease" (QUIP): Erratum.

    abstract::[This corrects the article on p. 49 in vol. 18, PMID: 25745311.]. ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 已发布勘误



    更新日期:2015-07-01 00:00:00

  • Endocrine, metabolic, nutritional, and toxic disorders leading to dementia.

    abstract::One of the first steps toward the correct diagnosis of dementia is to segregate out the nondegenerative dementias from possible degenerative dementias. Nondegenerative dementias could be due to traumatic, endocrine, metabolic, nutritional, toxic, infective, and immunological causes. They could also be caused by tumors...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章


    authors: Ghosh A

    更新日期:2010-12-01 00:00:00