Abstract:
OBJECTIVES:The precise pathophysiology of primary writing tremor (PWT) and writer's cramp (WC) is not known. The aim of this study is to compare the cerebral activation patterns in patients of PWT, WC and healthy controls, during a task of signing on paper, using functional magnetic resonance imaging (fMRI). MATERIALS AND METHODS:Six subjects with PWT, three with WC and six healthy volunteers were examined using a 1.5-Tesla scanner. The paradigm consisted of three times repetition of a set of period of rest and activity. Each set consisted of 10 blood oxygen level dependent (BOLD) echo-planar imaging (EPI) acquisitions at rest followed by 10 BOLD EPI acquisitions while signing their names on paper using the dominant right hand. Entire brain was covered. SPM99 analysis was done. RESULTS:IN COMPARISON TO THE HEALTHY CONTROLS, THE FOLLOWING DIFFERENCES IN CEREBRAL ACTIVATION WERE NOTED IN THE PATIENTS: (a) primary and supplementary motor areas showed overactivation in patients of PWT and underactivation in patients of WC, (b) the cingulate motor area showed underactivation in patients of PWT and overactivation in patients of WC and (c) the cerebellar activity was reduced in both WC and PWT. CONCLUSION:Our preliminary findings suggest that the cerebral and cerebellar activation patterns in PWT and WC during signing on paper are distinct from each other and from healthy controls. There may be cerebellar dysfunction in addition to motor dysfunctions in the pathogenesis of these disorders.
journal_name
Ann Indian Acad Neuroljournal_title
Annals of Indian Academy of Neurologyauthors
Sahni H,Jayakumar PN,Pal PKdoi
10.4103/0972-2327.70884subject
Has Abstractpub_date
2010-07-01 00:00:00pages
192-7issue
3eissn
0972-2327issn
1998-3549journal_volume
13pub_type
杂志文章abstract::This review is on ultrastructure and subcellular physiology at normal and abnormal neuromuscular junctions. The clinical and electrophysiological findings in myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), congenital myasthenic syndromes, and botulinum intoxication are discussed. Single fiber electromyogr...
journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.107690
更新日期:2013-01-01 00:00:00
abstract::We report a case of primary Sjögren's syndrome presenting with multiple cranial nerve palsies and radiological evidence of cranial pachymeningitis and hypophysitis. A 47-year-old woman developed right sensory neural hearing loss followed, 2 months later, by right facial palsy. Cranial magnetic resonance imaging showed...
journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.53083
更新日期:2009-04-01 00:00:00
abstract::Role of antiplatelet therapy in secondary stroke prevention is of major significance. Antiplatelet agents predominantly in use are aspirin, clopidogrel, and combination regimes. The review focuses on the optimization of antiplatelet regimen based on evidence obtained from randomized-controlled trials, on different ant...
journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.176866
更新日期:2016-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.120449
更新日期:2013-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.61280
更新日期:2010-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
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doi:10.4103/0972-2327.64645
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_357_19
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章,评审
doi:10.4103/0972-2327.128519
更新日期:2014-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.176861
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/aian.AIAN_298_18
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.41880
更新日期:2008-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_44_17
更新日期:2017-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.150586
更新日期:2015-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_389_17
更新日期:2018-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/aian.AIAN_233_18
更新日期:2020-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章,评审
doi:10.4103/aian.AIAN_16_18
更新日期:2018-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.175437
更新日期:2016-01-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_47_18
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.95000
更新日期:2012-04-01 00:00:00
abstract::The recent supreme court of India judgment on autonomy makes it necessary for all practicing neurologists to appraise themselves of the changing legal framework for End-of-Life decision-making in India. A pathway has been prescribed for advance care planning and medical futility decision-making. This is an evolving la...
journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_138_18
更新日期:2018-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.64625
更新日期:2010-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/0972-2327.138508
更新日期:2014-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.104343
更新日期:2012-10-01 00:00:00
abstract::Young onset dementia is a challenge. We describe a case, where a patient presented with psychosis, dementia and MRI showing pulvinar sign, all of this typical of variant Cruetzfelt Jacob disease (CJD). Subsequent investigations lead to the diagnosis of a treatable illness and patient was improved and MRI sign reversed...
journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.132645
更新日期:2014-04-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type: 杂志文章
doi:10.4103/aian.AIAN_27_20
更新日期:2020-07-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.120467
更新日期:2013-10-01 00:00:00
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journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.194413
更新日期:2016-10-01 00:00:00
abstract::Wasp and bee sting are commonly encountered worldwide. Local reactions are more common, generally are self-limiting and settle within a few hours. Multiple stings can lead to various clinical manifestations like vomiting, diarrhea, dyspnea, generalized edema, hypotension, syncope, acute renal failure, and even death. ...
journal_title:Annals of Indian Academy of Neurology
pub_type:
doi:10.4103/0972-2327.128581
更新日期:2014-01-01 00:00:00