Refining the Clinical Features of Serotonin Syndrome: A Prospective Observational Study of 45 Patients.

Abstract:

Introduction:Serotonin syndrome (SS) is a drug-induced clinical syndrome that results from the excess intrasynaptic concentration of serotonin. Prospective observations are limited for SS. Methods:We prospectively recruited 45 consecutive adult patients (>18 years) fulfilling the Hunter's criteria for SS. All patients were subjected to a detailed clinical history and examinations. Patients were subjected to appropriate investigations to find out the other causes. The causation of SS to serotonergic drugs was assessed according to Naranjo adverse drug reaction probability scale. Results:The mean age was 37.3 years (range: 18-59 years). Sixty-two percent of patients were male. There were 15 different underlying clinical syndromes for which serotonergic drugs were started. Psychiatry conditions (36%) and cough/respiratory tract infection (16%) were the two most common clinical conditions for starting serotonergic drugs. We noted 49 different symptoms and physical signs. Overall, tremor (78%) and dizziness (47%) were the two most common symptoms. Headache (16%) and dizziness (16%) were the two most common initial (or first) symptoms. However, gait difficulty and febrile encephalopathy were the two most common reasons to visit the hospital. We noted 18 different drugs causing SS. Thirty-eight percent of patients received single serotonergic agent antidepressants, pain medicines and cough syrups were other important drugs causing SS. Conclusions:This study represents the largest clinic-based study on SS. SS is not rare in clinical practice. However, various aspects of this syndrome are still to be determined. All patients on serotonergic drugs should be physically examined for the presence of SS on the development of any new symptom.

journal_name

Ann Indian Acad Neurol

authors

Prakash S,Rathore C,Rana KK,Dave A,Joshi H,Patel J

doi

10.4103/aian.AIAN_344_18

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

52-60

issue

1

eissn

0972-2327

issn

1998-3549

pii

AIAN-22-52

journal_volume

22

pub_type

杂志文章
  • Unusual presentation of Takayasu's arteritis as posterior reversible encephalopathy syndrome.

    abstract::Takayasu's arteritis is a chronic, idiopathic, inflammatory disease primarily affecting aorta and its branches. It mainly affects young females in the age group of 10-30 years. Various atypical presentations of Takayasu's arteritis have been described in children. These atypical presentations can cause delayed diagnos...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.85900

    authors: Zaki SA,Chavan V,Shanbag P

    更新日期:2011-07-01 00:00:00

  • Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke.

    abstract::Cerebral vasculitis secondary to Crohn's disease (CD) seems to be a very rare phenomenon. We report a 39-year-old male who presented with headache, vomiting, and left-sided weakness in the known case of CD. Cross-sectional imaging (computed tomography and magnetic resonance imaging,) showed right gangliocapsular acute...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.144035

    authors: Garge SS,Vyas PD,Modi PD,Ghatge S

    更新日期:2014-10-01 00:00:00

  • Rare ocular manifestation in a case of West Nile virus meningoencephalitis.

    abstract::West Nile Virus (WNV) is an arthropod-borne flavivirus, which causes flu-like illness and is sporadically associated with encephalitis. Transmission to humans occurs following a bite from an infected mosquito, which acquires the virus after feeding on dead birds. WNV meningoencephalitis is a rare infection with a neur...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.128564

    authors: Malhotra K,Ramanathan RS,Synowiec A,Rana S

    更新日期:2014-01-01 00:00:00

  • Glutaric aciduria type I: A treatable neurometabolic disorder.

    abstract:BACKGROUND AND OBJECTIVES:Glutaric aciduria Type-I (GA-I) has characteristic clinical and neuroimaging features, which clinches the diagnosis in a majority of patients. However, there have been few case reports on GA-I from India. This study was undertaken to study the clinical presentations, metabolic profile, neuroim...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.93273

    authors: Kamate M,Patil V,Chetal V,Darak P,Hattiholi V

    更新日期:2012-01-01 00:00:00

  • Role of vascular endothelial growth factor and other growth factors in post-stroke recovery.

    abstract::Stroke is a major health problem world-wide and its burden has been rising in last few decades. Until now tissue plasminogen activator is only approved treatment for stroke. Angiogenesis plays a vital role for striatal neurogenesis after stroke. Administration of various growth factors in an early post ischemic phase,...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章,评审

    doi:10.4103/0972-2327.128519

    authors: Talwar T,Srivastava MV

    更新日期:2014-01-01 00:00:00

  • Juvenile Myoclonic Epilepsy with Frontal Executive Dysfunction is Associated with Reduced Gray Matter Volume by Voxel-based Morphometry.

    abstract:OBJECTIVE:Frontal executive dysfunction (FED) and abnormalities in volumetric magnetic resonance imaging (MRI) have been described in juvenile myoclonic epilepsy (JME). We aimed to compare JME patients with and without FED by group analysis of voxel-based morphometric (VBM) estimates of brain volume in MRI. SUBJECTS A...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_44_17

    authors: Pillai SH,Raghavan S,Mathew M,Gopalan GM,Kesavadas C,Sarma S,Thomas SV

    更新日期:2017-07-01 00:00:00

  • Duchenne/Becker muscular dystrophy: A report on clinical, biochemical, and genetic study in Gujarat population, India.

    abstract:OBJECTIVE:In India, various groups have studied different regions to find out deletion pattern of dystrophin gene. We have investigated its deletion pattern among Duchenne/Becker muscular dystrophy (D/BMD) patients across Gujarat. Moreover, in this study we also correlate the same with reading frame rule. However, we t...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.138508

    authors: Rao MV,Sindhav GM,Mehta JJ

    更新日期:2014-07-01 00:00:00

  • "Dry" and "wet" beriberi mimicking critical illness polyneuropathy.

    abstract::Three cases with manifestations of right heart failure, shock, metabolic acidosis, and renal failure in varying combination were admitted with paraparesis. Nerve conduction study suggested predominantly motor and mainly axonal type of neuropathy. Rapid reversal of shock, acidosis, and multi-organ dysfunction with time...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.120467

    authors: Prakasha SR,Mustafa AS,Baikunje S,Subramanyam K

    更新日期:2013-10-01 00:00:00

  • Burden Faced by Caregivers of Stroke Patients Who Attend Rural-based Medical Teaching Hospital in Western India.

    abstract:Background:Stroke results in significant caregiver burden and strain. Objective:The main objectives of this study is to assess the burden and its consequences in caregivers of stroke patients and to determine the associated factors to caregivers' burden. Methods:A cross-sectional study was conducted over 1 year on 70...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_406_18

    authors: Mandowara B,Patel AN,Amin AA,Phatak A,Desai S

    更新日期:2020-01-01 00:00:00

  • Global workspace model of consciousness and its electromagnetic correlates.

    abstract::The global workspace of consciousness was proposed in its elementary framework by Baars, in 1982. Since the time of inception, there have been many speculations and modifications of this theory, but the central theme has remained the same, which refers to the global availability of information in the brain. However, t...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.42933

    authors: Prakash R,Prakash O,Prakash S,Abhishek P,Gandotra S

    更新日期:2008-07-01 00:00:00

  • Spinal coning after lumbar puncture in a patient with undiagnosed giant cervical neurofibroma.

    abstract::Lumbar puncture in the presence of an intracranial tumor with raised intracranial pressure is known to have catastrophic consequences due to herniation of intracranial contents through the tentorial hiatus or foramen magnum. There are relatively few case reports about the same sequence of events when lumbar puncture i...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.116935

    authors: Krishnan P,Roychowdhury S

    更新日期:2013-07-01 00:00:00

  • Vitamin D as a marker of cognitive decline in elderly Indian population.

    abstract:OBJECTIVES:Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. MATERIALS AND M...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.160052

    authors: Vedak TK,Ganwir V,Shah AB,Pinto C,Lele VR,Subramanyam A,Shah H,Deo SS

    更新日期:2015-07-01 00:00:00

  • Surgery for drug-resistant focal epilepsy.

    abstract::During the colloquium on drug-resistant epilepsy (DRE) at National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore on August 16-18, 2013, a number of presentations were made on the surgically remediable lesional epilepsy syndromes, presurgical evaluation, surgical techniques, neuropathology of drug r...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.128693

    authors: Rao MB,Arivazhagan A,Sinha S,Bharath RD,Mahadevan A,Bhat M,Satishchandra P

    更新日期:2014-03-01 00:00:00

  • Vasculitic Neuropathy: A Retrospective Analysis of Nerve Biopsies and Clinical Features from a Single Tertiary Care Center.

    abstract:Objective:Vasculitic neuropathy can be either restricted to the peripheral nerves or associated with systemic involvement of other organs. The objective of this study was to analyze the nerve biopsies reported as "vasculitic neuropathy" with clinical features. Materials and Methods:All cases diagnosed with vasculitic ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_47_18

    authors: Hui M,Meena AK,Rajasekhar L,Sireesha Y,Afshan J,Mridula R,Borgohain R,Uppin MS

    更新日期:2019-04-01 00:00:00

  • Low plasma antioxidant status in patients with epilepsy and the role of antiepileptic drugs on oxidative stress.

    abstract:BACKGROUND:Oxidative stress has been implicated in various disorders including epilepsy. We studied the antioxidant status in patients with epilepsy and aimed at determining whether there was any difference in the antioxidant levels between patients and controls, patients who are not on antiepileptic drugs (AEDs), and ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.144008

    authors: Menon B,Ramalingam K,Kumar RV

    更新日期:2014-10-01 00:00:00

  • Opercular myoclonic-anarthric status epilepticus: A report of two cases.

    abstract::Opercular myoclonic-anarthric status epilepticus (OMASE) is an uncommon disorder of diverse etiology. This condition is characterized by fluctuating cortical dysarthria associated with epileptic myoclonus involving glossopharyngeal musculature bilaterally. We report two cases of OMASE of vascular etiology in adults. I...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.120470

    authors: Bhaskara Rao JV,Vengamma B,Naveen T,Rao MS

    更新日期:2013-10-01 00:00:00

  • Repetitive transcranial magnetic stimulation in psychiatry.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and relatively painless tool that has been used to study various cognitive functions as well as to understand the brain-behavior relationship in normal individuals as well as in those with various neuropsychiatric disorders. It has also been used as...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.91935

    authors: Mishra BR,Sarkar S,Praharaj SK,Mehta VS,Diwedi S,Nizamie SH

    更新日期:2011-10-01 00:00:00

  • Multisystem involvement in neuromyelitis optica.

    abstract::We describe a case of pediatric neuromyelitis optica (NMO) with muscle and lung involvement in addition to central nervous system disease. Our patient initially presented with features of area postrema syndrome, then subsequently with optic neuritis. The patient also had recurrent hyperCKemia that responded to cortico...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.164830

    authors: Langille MM,Desai J

    更新日期:2015-09-01 00:00:00

  • Adult-onset Leigh's disease: A rare entity.

    abstract::Leigh syndrome (LS) is a heterogeneous familial or sporadic neurodegenerative disorder. It is typically seen in infancy or childhood, although rare cases of adult onset have been described. The authors describe a 37-year-old woman who presented with protracted gastrointestinal symptoms followed by acute brain stem syn...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.175437

    authors: Jabeen SA,Sandeep G,Mridula KR,Meena AK,Borgohain R,Sundaram C

    更新日期:2016-01-01 00:00:00

  • Clinical features and prognosis with Guillain-Barré syndrome.

    abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy commonly characterized by rapidly progressive, symmetric weakness and areflexia. MATERIALS AND METHODS:We retrospectively assessed the clinical manifestations, results of electrodiagnostic tests, functional status and prognosis of 36 chil...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.82793

    authors: Akbayram S,Doğan M,Akgün C,Peker E,Sayιn R,Aktar F,Bektaş MS,Caksen H

    更新日期:2011-04-01 00:00:00

  • Prevalence and Predictors of Female Sexual Dysfunction in Migraine.

    abstract:Background:Migraine is a common cause of primary headache, with women being affected thrice as common as men. Very few studies are available on sexual dysfunction in female migraineurs. There are no published studies done on the same in India till now. This study was done to look for the prevalence and predictors of se...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/aian.AIAN_508_18

    authors: Pradeep R,Sundarmurthy H,Karan V,Kulkarni P

    更新日期:2019-07-01 00:00:00

  • Secondary (Symptomatic) Trigeminal Autonomic Cephalalgia.

    abstract::Primary trigeminal autonomic cephalalgias (TACs) are uncommon group of headache disorders. These are defined and diagnosed by the criteria given by the International Classification of Headache Disorders 3β version. Over the past few decades, a number of secondary (symptomatic) cases have been described in the literatu...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章,评审

    doi:10.4103/aian.AIAN_16_18

    authors: Chowdhury D

    更新日期:2018-04-01 00:00:00

  • Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis.

    abstract::We describe a young patient of acute transverse myelitis (ATM) who developed true lower motor neuron (LMN) type flaccid paraplegia as a result of anterior horn cell damage in the region of cord inflammation that extended from conus upwards up to the D4 transverse level. We infer that flaccidity in acute phase of ATM i...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.138525

    authors: Pradhan S,Kumar A

    更新日期:2014-07-01 00:00:00

  • Case series of probable sporadic Creutzfeldt-Jakob disease from Eastern India.

    abstract:BACKGROUND:Creutzfeldt-Jakob disease is a rapidly progressive, fatal, transmissible neurodegenerative disorder caused by prion protein. It is still considered rare in countries like India. This is probably due to nonavailability of autopsy studies in majority of the center. The recent European diagnostic criterion for ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.120486

    authors: Biswas A,Khandelwal N,Pandit A,Roy A,Guin DS,Gangopadhyay G,Senapati A

    更新日期:2013-10-01 00:00:00

  • Sural sensory nerve action potential: A study in healthy Indian subjects.

    abstract:BACKGROUND:The sural sensory nerve action potential (SNAP) is an important electrodiagnostic study for suspected peripheral neuropathies. Incorrect technique and unavailability of reference data can lead to erroneous conclusions. OBJECTIVES:To establish reference data for sural SNAP in age-stratified healthy subjects ...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.186786

    authors: Sreenivasan A,Mansukhani KA,Sharma A,Balakrishnan L

    更新日期:2016-07-01 00:00:00

  • Benign familial neonatal convulsions: A family with a rare disorder.

    abstract::The authors report a family from Punjab (India) with 10 members having benign familial neonatal convulsions (also known as benign familial neonatal seizures) in two generations. This disorder is quite rare. The clinical presentation of index case along with the findings of computed tomography of the brain and electroe...

    journal_title:Annals of Indian Academy of Neurology

    pub_type:

    doi:10.4103/0972-2327.40227

    authors: Singh H,Raj R

    更新日期:2008-01-01 00:00:00

  • Perceived caregiver stress in Alzheimer's disease and mild cognitive impairment: A case control study.

    abstract:OBJECTIVES:Cross sectional studies have reported a tremendous amount of stress in caregivers of patients with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). The present study aimed at evaluating the perceived stress in caregivers of patients with AD and MCI compared to controls. MATERIALS AND METHODS:Ca...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.167695

    authors: Anand KS,Dhikav V,Sachdeva A,Mishra P

    更新日期:2016-01-01 00:00:00

  • Being ambulatory does not secure respiratory functions of Duchenne patients.

    abstract:AIM:The aim of this work was to assess the respiratory functions of ambulatory Duchenne patients and to propose an earlier time period for intervention. MATERIALS AND METHODS:Lung functions and North Star Ambulatory Assessment (NSAA) scores of Duchenne patients were evaluated simultaneously. RESULTS:Thirty ambulatory...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.85889

    authors: Ekici B,Ergül Y,Tatlı B,Bilir F,Binboğa F,Süleyman A,Tamay Z,Calışkan M,Güler N

    更新日期:2011-07-01 00:00:00

  • Coexistence of central nucleus, cores, and rods: Diagnostic relevance.

    abstract:BACKGROUND:Congenital myopathies (CMs) though considered distinct disorders, simultaneous occurrence of central nucleus, nemaline rods, and cores in the same biopsy are scarcely reported. OBJECTIVE:A retrospective reassessment of cases diagnosed as CMs to look for multiple pathologies missed, if any, during the initia...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.176861

    authors: Dhinakaran S,Kumar RS,Thakkar R,Narayanappa G

    更新日期:2016-04-01 00:00:00

  • Electrophysiological study in neuromuscular junction disorders.

    abstract::This review is on ultrastructure and subcellular physiology at normal and abnormal neuromuscular junctions. The clinical and electrophysiological findings in myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), congenital myasthenic syndromes, and botulinum intoxication are discussed. Single fiber electromyogr...

    journal_title:Annals of Indian Academy of Neurology

    pub_type: 杂志文章

    doi:10.4103/0972-2327.107690

    authors: Cherian A,Baheti NN,Iype T

    更新日期:2013-01-01 00:00:00