The changing landscape of hepatitis C virus therapy: focus on interferon-free treatment.


:Chronic hepatitis C (CHC) affects over 185 million individuals worldwide, approximately 3% of the world's population. CHC can lead to quality of life impairment, cirrhosis, hepatocellular carcinoma (HCC), liver failure and liver-related death. While CHC has been associated with increases in HCC, liver-related mortality and all-cause mortality, being cured of CHC is associated with improvement in these outcomes. Older interferon-based regimens were complex and toxic and required 6-12 months of therapy, with cure rates averaging around 40-45% for HCV genotype 1. Newer interferon-free regimens are now available in the US, Europe, Japan and in other countries. These regimens have short durations, minimal side effects, low pill burden and efficacy approaching 90-100%. We may eventually see single-tablet regimens lasting no more than 4-6 weeks. This review will summarize the data regarding these interferon-free regimens, including Gilead's Harvoni (sofosbuvir/ledipasvir), AbbVie's Viekira Pak (paritaprevir/ritonavir/ombitasvir with dasabuvir), and Janssen's Olysio (simeprevir) with sofosbuvir. Some practical considerations as we move into an interferon-free era will also be discussed, such as patient adherence and drug-drug interactions.


Lam BP,Jeffers T,Younoszai Z,Fazel Y,Younossi ZM




Has Abstract


2015-09-01 00:00:00














  • External validation of two prediction tools for patients at risk for recurrent Clostridioides difficile infection.

    abstract:Background:One in four patients with primary Clostridioides difficile infection (CDI) develops recurrent CDI (rCDI). With every recurrence, the chance of a subsequent CDI episode increases. Early identification of patients at risk for rCDI might help doctors to guide treatment. The aim of this study was to externally v...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: van Rossen TM,van Dijk LJ,Heymans MW,Dekkers OM,Vandenbroucke-Grauls CMJE,van Beurden YH

    更新日期:2021-01-09 00:00:00

  • Hepatocellular carcinoma: review of current treatment with a focus on targeted molecular therapies.

    abstract::The treatment of hepatocellular carcinoma (HCC) remains a challenge, with 1- and 3-year survival rates of 20% and 5%, respectively, and a median survival of 8 months. However, a better understanding of the pathogenesis of HCC, and advances in targeted molecular therapies provide physicians treating this disease with n...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Olsen SK,Brown RS,Siegel AB

    更新日期:2010-01-01 00:00:00

  • The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.

    abstract:Background:Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Tyrovolas S,Panagiotakos DB,Georgousopoulou EN,Chrysohoou C,Skoumas J,Pan W,Tousoulis D,Pitsavos C

    更新日期:2019-06-23 00:00:00

  • Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks.

    abstract:Background:Recently the American Society for Gastrointestinal Endoscopy addressed the 'resect and discard' strategy, determining that accurate in vivo differentiation of colorectal polyps (CP) is necessary. Previous studies have suggested a promising application of artificial intelligence (AI), using deep learning in o...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Ozawa T,Ishihara S,Fujishiro M,Kumagai Y,Shichijo S,Tada T

    更新日期:2020-03-20 00:00:00

  • Host-targeting therapies for hepatitis C virus infection: current developments and future applications.

    abstract::Chronic hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases and hepatocellular carcinoma (HCC) worldwide. In the past few years, anti-HCV therapies have undergone a revolution with the approval of multiple direct-acting antivirals (DAAs), which enable interferon-free treatments with consider...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Crouchet E,Wrensch F,Schuster C,Zeisel MB,Baumert TF

    更新日期:2018-03-21 00:00:00

  • Certolizumab pegol for the treatment of Crohn's disease.

    abstract::In this article we provide a contemporary overview of available clinical data on certolizumab pegol, a pegylated anti-tumor necrosis factor (TNF) alpha agent that comprises a uniquely small protein, and its emerging role as a therapy for Crohn's disease (CD). The results from a comprehensive clinical trial program sug...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Schreiber S

    更新日期:2011-11-01 00:00:00

  • Combined radiological-endoscopic management of difficult bile duct stones: 18-year single center experience.

    abstract:OBJECTIVES:Clinical evidence regarding radiological-endoscopic management of intrahepatic bile duct stones is currently lacking. Our aim is to report our 18-year experience in combined radiological-endoscopic management of intrahepatic difficult bile duct stones. METHODS:From June 1994 to June 2012, 299 symptomatic pa...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Cannavale A,Bezzi M,Cereatti F,Lucatelli P,Fanello G,Salvatori FM,Fanelli F,Fiocca F,Donatelli G

    更新日期:2015-11-01 00:00:00

  • Management of patients with faecal incontinence.

    abstract::Faecal incontinence, defined as the involuntary loss of solid or liquid stool, is a common problem affecting 0.8-8.3% of the adult population. Individuals suffering from faecal incontinence often live a restricted life with reduced quality of life. The present paper is a clinically oriented review of the pathophysiolo...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Duelund-Jakobsen J,Worsoe J,Lundby L,Christensen P,Krogh K

    更新日期:2016-01-01 00:00:00

  • Erratum for PMID 21180585.

    abstract::Erratum to 'Possible interactions between dietary fibres and 5-aminosalicyclic acid' by C Henriksen, S Hansen, I Nordgaard-Lassen, J Rikardt Anderson and P Madsen. Therapeutic Advances in Gastroenterology (2010) 3(1) 5-9 [DOI: 10.1177/ 1756283X09347810][This corrects the article on p. 5 in vol. 3.]. ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 已发布勘误



    更新日期:2012-09-01 00:00:00

  • Efficacy and safety of adalimumab in Chinese patients with moderately to severely active Crohn's disease: results from a randomized trial.

    abstract:Background and Aims:Efficacy of adalimumab in Crohn's disease (CD) has not been shown in China. The aim of this study was to evaluate the efficacy and safety of adalimumab in Chinese patients with CD. Methods:This 26-week, multicenter, phase III study evaluated patients with moderately to severely active CD and elevat...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Chen B,Gao X,Zhong J,Ren J,Zhu X,Liu Z,Wu K,Kalabic J,Yu Z,Huang B,Kwatra N,Doan T,Robinson AM,Chen MH

    更新日期:2020-07-16 00:00:00

  • Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease.

    abstract::Monoclonal antibodies to tumor necrosis factor (TNF) have become a mainstay of the therapeutic armamentarium in inflammatory bowel disease (IBD) over the last 15 years. Although highly effective, primary and secondary nonresponse are common and associated with poor clinical outcomes and significant costs. Multiple cli...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Kopylov U,Seidman E

    更新日期:2016-07-01 00:00:00

  • Hereditary pancreatitis for the endoscopist.

    abstract::Hereditary pancreatitis shares a majority of clinical and morphologic features with chronic alcoholic pancreatitis, but may present at an earlier age. The term hereditary pancreatitis has primarily been associated with mutations in the serine protease 1 gene (PRSS1) which encodes for cationic trypsinogen. PRSS1 mutati...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Patel MR,Eppolito AL,Willingham FF

    更新日期:2013-03-01 00:00:00

  • Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer.

    abstract::Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Liu X,Yang Z,Latchoumanin O,Qiao L

    更新日期:2016-11-01 00:00:00

  • Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance.

    abstract:BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosph...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Ammendola M,Sacco R,Vescio G,Zuccalà V,Luposella M,Patruno R,Zizzo N,Gadaleta C,Marech I,Ruggieri R,Kocak IF,Ozgurtas T,Gadaleta CD,Sammarco G,Ranieri G

    更新日期:2017-04-01 00:00:00

  • Optimal use of biologics in the management of Crohn's disease.

    abstract::Crohn's disease (CD) is a chronic relapsing and remitting disorder of the gastrointestinal tract with no known cure. The inflammation that drives the disease can lead to debilitating symptoms and a number of complications that may lead to surgery. The introduction of biologic therapy a decade ago has offered a new opt...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Panaccione R,Ghosh S

    更新日期:2010-05-01 00:00:00

  • Pancreatic neuroendocrine tumors: approach to treatment with focus on sunitinib.

    abstract::Pancreatic neuroendocrine tumors (pNETs) are relatively rare malignancies. With secretory tumors such as insulinomas, vasoactive intestinal peptideomas, and gastrinomas, the hormone produced causes the symptom complex (e.g. hypoglycemia, peptic ulcer disease). With nonsecretory NETs, the clinical condition is determin...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Vinik AI,Raymond E

    更新日期:2013-09-01 00:00:00

  • Targeting neutrophil extracellular traps in severe acute pancreatitis treatment.

    abstract::Severe acute pancreatitis (SAP) is a critical abdominal disease associated with high death rates. A systemic inflammatory response promotes disease progression, resulting in multiple organ dysfunction. The functions of neutrophils in the pathology of SAP have been presumed traditionally to be activation of chemokine a...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Hu J,Kang H,Chen H,Yao J,Yi X,Tang W,Wan M

    更新日期:2020-11-24 00:00:00

  • Current status of first- and second-line Helicobacter pylori eradication therapy in the metropolitan area: a multicenter study with a large number of patients.

    abstract:Background:The environment surrounding Helicobacter pylori eradication treatment is dramatically changing. Recently, vonoprazan, a first-in-class potassium-competitive acid blocker (P-CAB), was introduced onto the market in 2015. The aging of Japan's demographic structure is becoming pronounced. In this study, we exami...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Mori H,Suzuki H,Omata F,Masaoka T,Asaoka D,Kawakami K,Mizuno S,Kurihara N,Nagahara A,Sakaki N,Ito M,Kawamura Y,Suzuki M,Shimada Y,Sasaki H,Matsuhisa T,Torii A,Nishizawa T,Mine T,Ohkusa T,Kawai T,Tokunaga K,Tak

    更新日期:2019-07-04 00:00:00

  • The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

    abstract::Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological cond...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Bien J,Palagani V,Bozko P

    更新日期:2013-01-01 00:00:00

  • Screening colonoscopy bowel preparation: experience in an urban minority population.

    abstract:METHODS:Suboptimal bowel preparation, present in over 20% of colonoscopies, can severely compromise the effectiveness of the colonoscopy procedure. We surveyed 93 primarily urban minority men and women who underwent asymptomatic 'screening' colonoscopy regarding their precolonoscopy bowel-preparation experience. RESUL...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Basch CH,Basch CE,Wolf RL,Zybert P,Lebwohl B,Shmukler C,Neugut AI,Shea S

    更新日期:2013-11-01 00:00:00

  • Incidence of Clostridioides difficile infection in peripartum women: a retrospective cohort study.

    abstract:Background:The incidence of Clostridioides difficile infection (CDI) is increasing in the general population. Data on the epidemiology of CDI in peripartum women - a highly vulnerable patient population - is scarce. The objective of this study was to report the incidence of CDI in peripartum women. Methods:A single-ce...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Saha S,Pardi R,Theiler RN,Pardi DS,Khanna S

    更新日期:2020-07-27 00:00:00

  • Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies.

    abstract:BACKGROUND:Some chronic hepatitis C virus (HCV), genotype 1 infected patients treated with direct antiviral agents (DAAs) remain viremic at end of treatment (EOT+), yet go on to achieve sustained virological response 12 weeks after completion of therapy (SVR12). The incidence of EOT+/SVR in patients with genotype 1 and...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Malespin M,Benyashvili T,Uprichard SL,Perelson AS,Dahari H,Cotler SJ

    更新日期:2017-01-01 00:00:00

  • Fully covered self-expandable metal stent in the treatment of postsurgical colorectal diseases: outcome in 29 patients.

    abstract:BACKGROUND:Self-expandable metal stent (SEMS) placement is a minimally invasive treatment for palliation of malignant colorectal strictures and as a bridge to surgery. However, the use of SEMS for benign colorectal diseases is controversial. The purpose of this retrospective study is to evaluate the efficacy and safety...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Cereatti F,Fiocca F,Dumont JL,Ceci V,Vergeau BM,Tuszynski T,Meduri B,Donatelli G

    更新日期:2016-03-01 00:00:00

  • Correlation between serum gastrin and cellular proliferation in Barrett's esophagus.

    abstract:BACKGROUND:Patients with Barrett's esophagus (BE) are commonly treated with proton-pump inhibitors (PPIs) to minimize the exposure of esophageal mucosa to stomach acid. However, the use of these medications can lead to significant hypergastrinemia in a subset of patients, which is concerning due to the known tumorigeni...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Green DA,Mlynarczyk CM,Vaccaro BJ,Capiak KM,Quante M,Lightdale CJ,Abrams JA

    更新日期:2011-03-01 00:00:00

  • Effectiveness of endoscopic ultrasound-guided drainage for noncapsulated postoperative pancreatic collection.

    abstract:Background:Postoperative pancreatic collection (POPC) is a frequent complication after pancreatectomy. Although percutaneous drainage (PD) has been the treatment of choice for POPC with encapsulation, endoscopic ultrasound-guided transmural drainage (EUS-TD) was recently reported effective for this condition. The main ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Tamura T,Kitano M,Kawai M,Tanioka K,Itonaga M,Kawaji Y,Nuta J,Hatamaru K,Yamashita Y,Kitahata Y,Miyazawa M,Hirono S,Okada KI,Yamaue H

    更新日期:2019-10-24 00:00:00

  • Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews.

    abstract:Background:Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potenti...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Chu MHK,Wu IXY,Ho RST,Wong CHL,Zhang AL,Zhang Y,Wu JCY,Chung VCH

    更新日期:2018-07-16 00:00:00

  • Effective treatment of chronic radiation proctitis using radiofrequency ablation.

    abstract::Endoscopic argon plasma coagulation and bipolar electrocautery are currently preferred treatments for chronic radiation proctitis, but ulcerations and strictures frequently occur. Radiofrequency ablation (RFA) has been successful for mucosal ablation in the esophagus. Here we report the efficacy of RFA with the BarRx ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Zhou C,Adler DC,Becker L,Chen Y,Tsai TH,Figueiredo M,Schmitt JM,Fujimoto JG,Mashimo H

    更新日期:2009-01-01 00:00:00

  • Prophylaxis of hepatitis B infection in solid organ transplant recipients.

    abstract::Rates of transmission of hepatitis B virus (HBV) infection from organ donors with HBV markers to recipients along with reactivation of HBV during immunosuppression following transplantation have fallen significantly with the advent of hepatitis B immune globulin (HBIg) and effective antiviral therapy. Although the ava...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: John S,Andersson KL,Kotton CN,Hertl M,Markmann JF,Cosimi AB,Chung RT

    更新日期:2013-07-01 00:00:00

  • EUS-guided FNA for biliary disease as first-line modality to obtain histological evidence.

    abstract:BACKGROUND:Few reports have described endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) for biliary lesions. In addition, adverse events were not completely examined in previous reports, due to the inclusion of cases in which biliary stents had already been placed. The present study aimed to investigate t...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Onda S,Ogura T,Kurisu Y,Masuda D,Sano T,Takagi W,Fukunishi S,Higuchi K

    更新日期:2016-05-01 00:00:00

  • Evaluation of regional and whole gut motility using the wireless motility capsule: relevance in clinical practice.

    abstract::The wireless motility capsule (WMC) is an ambulatory noninvasive and nonradioactive diagnostic sensor that continuously samples intraluminal pH, temperature, and pressure as it moves through the gastrointestinal (GI) tract. This review summarizes the data obtained in clinical trials with the WMC and discusses its role...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Tran K,Brun R,Kuo B

    更新日期:2012-07-01 00:00:00