Clostridium difficile infection: management strategies for a difficult disease.

abstract：:Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (...

journal_title：Therapeutic advances in gastroenterology

authors： Liu X,Yang Z,Latchoumanin O,Qiao L

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Endoscopic therapy for early neoplasia in Barrett's esophagus (BE) is evolving. Endoscopic resection has an increasing role. We wanted to evaluate the safety and efficacy of multi-band ligation/resection [ER-L] without pre-injection in BE with high-grade dysplasia [HGD] and intramucosal carcinoma [IMCA]. ME...

journal_title：Therapeutic advances in gastroenterology

authors： Bhat YM,Furth EE,Brensinger CM,Ginsberg GG

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosph...

journal_title：Therapeutic advances in gastroenterology

authors： Ammendola M,Sacco R,Vescio G,Zuccalà V,Luposella M,Patruno R,Zizzo N,Gadaleta C,Marech I,Ruggieri R,Kocak IF,Ozgurtas T,Gadaleta CD,Sammarco G,Ranieri G

更新日期：2017-04-01 00:00:00

abstract：:On 31 December 2019, the WHO China Country Office was informed of cases of pneumonia of unknown etiology detected in Wuhan (Hubei Province of China). In January 2020, a new coronavirus named SARS-CoV2 was isolated and, since that time, SARS-CoV2 related disease (COVID-19) rapidly spread all over the world becoming pan...

journal_title：Therapeutic advances in gastroenterology

authors： Bove V,Schepis T,Boškoski I,Landi R,Orlandini B,Pontecorvi V,Familiari P,Tringali A,Perri V,Costamagna G

更新日期：2020-06-24 00:00:00

abstract：:Hereditary pancreatitis shares a majority of clinical and morphologic features with chronic alcoholic pancreatitis, but may present at an earlier age. The term hereditary pancreatitis has primarily been associated with mutations in the serine protease 1 gene (PRSS1) which encodes for cationic trypsinogen. PRSS1 mutati...

journal_title：Therapeutic advances in gastroenterology

authors： Patel MR,Eppolito AL,Willingham FF

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Few reports have described endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) for biliary lesions. In addition, adverse events were not completely examined in previous reports, due to the inclusion of cases in which biliary stents had already been placed. The present study aimed to investigate t...

journal_title：Therapeutic advances in gastroenterology

authors： Onda S,Ogura T,Kurisu Y,Masuda D,Sano T,Takagi W,Fukunishi S,Higuchi K

更新日期：2016-05-01 00:00:00

abstract：Background:Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn's disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on disease activity in a large CD cohort. Methods:We performed a retrospective analysis of patients with established CD w...

journal_title：Therapeutic advances in gastroenterology

authors： Chen R,Li L,Chao K,Hong M,Cao Q,Ye L,Zhou G,Fang X,Guo H,Cao X,Ye X,Zeng Z,Chen M,Zhang S

更新日期：2020-12-21 00:00:00

abstract：Objective:i-Scan is a digital image enhancement technology, reported to improve diagnostic performance during endoscopy. Previous studies have investigated the accuracy of i-scan for distinguishing between neoplastic and non-neoplastic colonic polyps and suggested diagnostic accuracy close to that required for use in r...

journal_title：Therapeutic advances in gastroenterology

authors： Glover B,Patel N,Ashrafian H,Teare J

更新日期：2018-12-06 00:00:00

abstract：:Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with significant morbidity and mortality. A number of risk factors have been associated with AF, though few studies have explored the association between gastrointestinal and liver diseases and AF. Additionally, AF and treatment for AF ...

journal_title：Therapeutic advances in gastroenterology

authors： Long MT,Ko D,Arnold LM,Trinquart L,Sherer JA,Keppel SS,Benjamin EJ,Helm RH

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Some chronic hepatitis C virus (HCV), genotype 1 infected patients treated with direct antiviral agents (DAAs) remain viremic at end of treatment (EOT+), yet go on to achieve sustained virological response 12 weeks after completion of therapy (SVR12). The incidence of EOT+/SVR in patients with genotype 1 and...

journal_title：Therapeutic advances in gastroenterology

authors： Malespin M,Benyashvili T,Uprichard SL,Perelson AS,Dahari H,Cotler SJ

更新日期：2017-01-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (pNETs) are relatively rare malignancies. With secretory tumors such as insulinomas, vasoactive intestinal peptideomas, and gastrinomas, the hormone produced causes the symptom complex (e.g. hypoglycemia, peptic ulcer disease). With nonsecretory NETs, the clinical condition is determin...

journal_title：Therapeutic advances in gastroenterology

authors： Vinik AI,Raymond E

更新日期：2013-09-01 00:00:00

abstract：:Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated b...

journal_title：Therapeutic advances in gastroenterology

authors： Vilaseca M,Guixé-Muntet S,Fernández-Iglesias A,Gracia-Sancho J

更新日期：2018-11-25 00:00:00

abstract：BACKGROUND:Diarrhea-predominant irritable bowel syndrome (IBS-D) impairs patient quality of life (QOL). Rifaximin is an oral, nonsystemic antibiotic indicated for IBS-D. The objective of this secondary analysis was to evaluate rifaximin retreatment on IBS-related QOL in patients with IBS-D. METHODS:Patients received o...

journal_title：Therapeutic advances in gastroenterology

authors： Cash BD,Pimentel M,Rao SSC,Weinstock L,Chang L,Heimanson Z,Lembo A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Patients with Barrett's esophagus (BE) are commonly treated with proton-pump inhibitors (PPIs) to minimize the exposure of esophageal mucosa to stomach acid. However, the use of these medications can lead to significant hypergastrinemia in a subset of patients, which is concerning due to the known tumorigeni...

journal_title：Therapeutic advances in gastroenterology

authors： Green DA,Mlynarczyk CM,Vaccaro BJ,Capiak KM,Quante M,Lightdale CJ,Abrams JA

更新日期：2011-03-01 00:00:00

abstract：:In 2010, four independent groups almost simultaneously reported the association of the novel interleukin-1 (IL-1) family member, IL-33, with inflammatory bowel disease (IBD). The findings were remarkably consistent and demonstrated that IL-33 is markedly upregulated in, and specific to, ulcerative colitis (UC). In add...

journal_title：Therapeutic advances in gastroenterology

authors： Pastorelli L,De Salvo C,Cominelli MA,Vecchi M,Pizarro TT

更新日期：2011-09-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is becoming the most common cause of chronic liver disease in the developing world, found in 17-30% of the population in Western countries and 2-4% worldwide. Defined as the accumulation of fatty acid content greater than 5% of liver weight, NAFLD is a spectrum of disease rangi...

journal_title：Therapeutic advances in gastroenterology

authors： Kneeman JM,Misdraji J,Corey KE

更新日期：2012-05-01 00:00:00

abstract：:In this article we provide a contemporary overview of available clinical data on certolizumab pegol, a pegylated anti-tumor necrosis factor (TNF) alpha agent that comprises a uniquely small protein, and its emerging role as a therapy for Crohn's disease (CD). The results from a comprehensive clinical trial program sug...

journal_title：Therapeutic advances in gastroenterology

authors： Schreiber S

更新日期：2011-11-01 00:00:00

abstract：:Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological cond...

journal_title：Therapeutic advances in gastroenterology

authors： Bien J,Palagani V,Bozko P

更新日期：2013-01-01 00:00:00

abstract：Background:Variability in glucagon-like peptide (GLP)-1 and GLP-2 plasma concentrations has been suggested in Celiac disease (CD), with inconclusive results. We assessed the association between serum levels of GLP-1 and GLP-2 and their duodenal receptor expression in children with and without CD. Methods:This was a tw...

journal_title：Therapeutic advances in gastroenterology

authors： Rachmiel M,Ben-Yehudah G,Shirin H,Broide E

更新日期：2019-04-17 00:00:00

abstract：Background and Aims:Efficacy of adalimumab in Crohn's disease (CD) has not been shown in China. The aim of this study was to evaluate the efficacy and safety of adalimumab in Chinese patients with CD. Methods:This 26-week, multicenter, phase III study evaluated patients with moderately to severely active CD and elevat...

journal_title：Therapeutic advances in gastroenterology

authors： Chen B,Gao X,Zhong J,Ren J,Zhu X,Liu Z,Wu K,Kalabic J,Yu Z,Huang B,Kwatra N,Doan T,Robinson AM,Chen MH

更新日期：2020-07-16 00:00:00

abstract：Background:Recently the American Society for Gastrointestinal Endoscopy addressed the 'resect and discard' strategy, determining that accurate in vivo differentiation of colorectal polyps (CP) is necessary. Previous studies have suggested a promising application of artificial intelligence (AI), using deep learning in o...

journal_title：Therapeutic advances in gastroenterology

authors： Ozawa T,Ishihara S,Fujishiro M,Kumagai Y,Shichijo S,Tada T

更新日期：2020-03-20 00:00:00

abstract：:Faecal incontinence, defined as the involuntary loss of solid or liquid stool, is a common problem affecting 0.8-8.3% of the adult population. Individuals suffering from faecal incontinence often live a restricted life with reduced quality of life. The present paper is a clinically oriented review of the pathophysiolo...

journal_title：Therapeutic advances in gastroenterology

authors： Duelund-Jakobsen J,Worsoe J,Lundby L,Christensen P,Krogh K

更新日期：2016-01-01 00:00:00

abstract：Background:Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potenti...

journal_title：Therapeutic advances in gastroenterology

authors： Chu MHK,Wu IXY,Ho RST,Wong CHL,Zhang AL,Zhang Y,Wu JCY,Chung VCH

更新日期：2018-07-16 00:00:00

abstract：OBJECTIVES:Clinical evidence regarding radiological-endoscopic management of intrahepatic bile duct stones is currently lacking. Our aim is to report our 18-year experience in combined radiological-endoscopic management of intrahepatic difficult bile duct stones. METHODS:From June 1994 to June 2012, 299 symptomatic pa...

journal_title：Therapeutic advances in gastroenterology

authors： Cannavale A,Bezzi M,Cereatti F,Lucatelli P,Fanello G,Salvatori FM,Fanelli F,Fiocca F,Donatelli G

更新日期：2015-11-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a critical abdominal disease associated with high death rates. A systemic inflammatory response promotes disease progression, resulting in multiple organ dysfunction. The functions of neutrophils in the pathology of SAP have been presumed traditionally to be activation of chemokine a...

journal_title：Therapeutic advances in gastroenterology

authors： Hu J,Kang H,Chen H,Yao J,Yi X,Tang W,Wan M

更新日期：2020-11-24 00:00:00

abstract：Background:Recurrent Clostridium difficile infection (rCDI) is becoming increasingly common. Faecal microbiota transplantation (FMT) is effective for rCDI, but the costs of an FMT and hospital cost savings related to FMT are unknown. The aim of this study was to calculate the cost of an FMT and the total hospital costs...

journal_title：Therapeutic advances in gastroenterology

authors： Dehlholm-Lambertsen E,Hall BK,Jørgensen SMD,Jørgensen CW,Jensen ME,Larsen S,Jensen JS,Ehlers L,Dahlerup JF,Hvas CL

更新日期：2019-04-10 00:00:00

abstract：:In recent years, mucosal healing has emerged as a key therapeutic goal in the clinical management of patients with Crohn's disease, as it has been associated with improved long-term clinical outcomes. With the vast improvements in endoscopic imaging techniques and the increase in available treatment options, which rep...

journal_title：Therapeutic advances in gastroenterology

authors： Klenske E,Bojarski C,Waldner M,Rath T,Neurath MF,Atreya R

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Dual red imaging (DRI), a novel image-enhanced endoscopic technique, is expected to improve visibility of thin vessels, but no reports of the clinical use of DRI in colorectal endoscopic submucosal dissection (ESD) have been published. We aimed to compare the visibility of vessels, demarcation line between t...

journal_title：Therapeutic advances in gastroenterology

authors： Ninomiya Y,Oka S,Tanaka S,Hirano D,Sumimoto K,Tamaru Y,Asayama N,Shigita K,Nishiyama S,Hayashi N,Chayama K

更新日期：2016-09-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic relapsing and remitting disorder of the gastrointestinal tract with no known cure. The inflammation that drives the disease can lead to debilitating symptoms and a number of complications that may lead to surgery. The introduction of biologic therapy a decade ago has offered a new opt...

journal_title：Therapeutic advances in gastroenterology

authors： Panaccione R,Ghosh S

更新日期：2010-05-01 00:00:00

abstract：:The wireless motility capsule (WMC) is an ambulatory noninvasive and nonradioactive diagnostic sensor that continuously samples intraluminal pH, temperature, and pressure as it moves through the gastrointestinal (GI) tract. This review summarizes the data obtained in clinical trials with the WMC and discusses its role...

journal_title：Therapeutic advances in gastroenterology

authors： Tran K,Brun R,Kuo B

更新日期：2012-07-01 00:00:00