Prolonged efficacy of pembrolizumab in a patient presenting a multi-treated metastatic hepatocholangiocarcinoma.

Abstract:

Introduction:Hepatocholangiocarcinoma (HCC-ICC) is a rare tumor presenting the histologic characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). As there is no consensus on it management, the therapeutic strategy rests on the specific treatments for HCC or ICC. Programmed cell death 1 (PD-1) inhibitors showed encouraging results in the second line treatment of HCC after sorafenib but it efficacy in HCC-ICC has never been reported. Methods and results:We present the case of a 72-year-old male patient treated for metastatic HCC-ICC due to a viral hepatitis C cirrhosis in progression after two lines of treatment. Tumor was characterized by a PDL-1 status of 85%. Patient received pembrolizumab at doses of 200 mg every 21 days by intravenous infusion. After one injection he was presented an immediate clinical benefit, a partial response was observed after two months of treatment and a complete response two months later. This response was maintained over time along with toxicity-free tumor control after 18 months treatment. Conclusion:To our knowledge, we reported for the first time the efficacy of a PD1 inhibitor treatment in a patient presenting metastatic HCC-ICC due to viral cirrhosis and overexpressing PDL-1 after failure of two lines of treatment.

authors

Saint A,Benchetrit M,Novellas S,Ouzan D,Falk AT,Leysalle A,Barriere J

doi

10.1177/1756284820935189

subject

Has Abstract

pub_date

2020-06-20 00:00:00

pages

1756284820935189

eissn

1756-283X

issn

1756-2848

pii

10.1177_1756284820935189

journal_volume

13

pub_type

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    authors: Onda S,Ogura T,Kurisu Y,Masuda D,Sano T,Takagi W,Fukunishi S,Higuchi K

    更新日期:2016-05-01 00:00:00

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    更新日期:2020-04-28 00:00:00

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    journal_title:Therapeutic advances in gastroenterology

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    doi:10.1177/1756284820977385

    authors: van Rossen TM,van Dijk LJ,Heymans MW,Dekkers OM,Vandenbroucke-Grauls CMJE,van Beurden YH

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    abstract::Several clinical trials and experimental studies strongly suggest a place for Saccharomyces boulardii as a biotherapeutic agent for the prevention and treatment of several gastrointestinal diseases. S. boulardii mediates responses resembling the protective effects of the normal healthy gut flora. The multiple mechanis...

    journal_title:Therapeutic advances in gastroenterology

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    doi:10.1177/1756283X11428502

    authors: Kelesidis T,Pothoulakis C

    更新日期:2012-03-01 00:00:00