MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression.

abstract：:The epidermal growth factor receptor (EGFR) network has rich targets for prostate cancer killing. Herein we evaluated the effects of combining the EGFR inhibition and radiation on DU145 prostate cancer. We treated DU145 prostate cancer cells with various doses of anti-EGFR antibody (C225) and gamma-irradiation (RAD). ...

journal_title：Oncology reports

authors： Wagener M,Zhang X,Villarreal HG,Levy L,Allen P,Shentu S,Fang B,Krishnan S,Chang JY,Cheung MR

更新日期：2008-05-01 00:00:00

abstract：:The emergence of radioresistance is a significant issue in the treatment of squamous cell carcinoma. We recently demonstrated that post-radiogenic extracellular signal-regulated kinase (ERK) signaling might decrease radiosensitivity in this cancer type. To further elucidate how tumo...

journal_title：Oncology reports

authors： Affolter A,Schmidtmann I,Mann WJ,Brieger J

更新日期：2013-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most common cause of gynecological cancer-related mortality. Clear cell EOC (cEOC) has a number of clinical features distinguishing it from other EOC because of frequent concurrence of endometriosis and highly chemoresistant nature resulting in a poor prognosis. Recent biochemica...

journal_title：Oncology reports

authors： Kajihara H,Yamada Y,Kanayama S,Furukawa N,Noguchi T,Haruta S,Yoshida S,Sado T,Oi H,Kobayashi H

更新日期：2010-05-01 00:00:00

abstract：:Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...

journal_title：Oncology reports

authors： Sun W,Wang W,Lei J,Li H,Wu Y

更新日期：2017-04-01 00:00:00

abstract：:It is well known that low-dose metronomic chemotherapy has antiangiogenic activity. The aim of the present trial was to investigate the antiangiogenic properties of weekly docetaxel in patients with metastatic breast cancer. In total, 157 metastatic breast cancer patients received 3...

journal_title：Oncology reports

authors： Pectasides D,Papaxoinis G,Kotoula V,Fountzilas H,Korantzis I,Koutras A,Dimopoulos AM,Papakostas P,Aravantinos G,Varthalitis I,Kosmidis P,Skarlos D,Bournakis E,Bafaloukos D,Kalofonos HP,Kalogeras KT,Fountzilas G

更新日期：2012-01-01 00:00:00

abstract：:Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...

journal_title：Oncology reports

authors： Wei C,Lu N,Wang L,Zhang Y,Feng Z,Yang Y,Qi F,Gu J

更新日期：2018-06-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common causes of cancer‑related mortality worldwide. Despite remarkable progress in the diagnosis and treatment of GC, a large number of cases are diagnosed as advanced GC, and treatment failure occurs. Emerging evidence has shown that non‑coding RNAs (ncRNAs), especially microRN...

journal_title：Oncology reports

authors： Shao Z,Gao D,Chen L,Ding W,Yu Q

更新日期：2020-10-01 00:00:00

abstract：:Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We an...

journal_title：Oncology reports

authors： Izawa H,Yamamoto H,Ikeda M,Ikeda K,Fukunaga H,Yasui M,Ikenaga M,Sekimoto M,Monden T,Matsuura N,Monden M

更新日期：2002-11-01 00:00:00

abstract：:Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumor suppressor gene and its expression is downregulated by promoter methylation in many malignances. In the present study, we ex...

journal_title：Oncology reports

authors： Qiu C,Bu X,Jiang Z

更新日期：2016-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Tumor specific cellular and humoral immunotherapy may be a viable approach for the treatment of HCC. This study investigated specific inhibitory and cytotoxic effects on hepatocellular carcinoma (HCC) induced by the peptide, designated HBc Delt...

journal_title：Oncology reports

authors： Kong J,Diao Z,Deng X,Zhong H,Yao W,Hu X

更新日期：2007-07-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) accounts for over 80% of all diagnosed lung cancer cases. Lung cancer is the leading cause of cancer‑related deaths worldwide. Most NSCLC cells overexpress vascular endothelial growth factor‑A (VEGF‑A) which plays a pivotal role in tumour angiogenesis. Anti‑angiogenic therapies inclu...

journal_title：Oncology reports

authors： Eguchi R,Wakabayashi I

更新日期：2020-07-01 00:00:00

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:MicroRNAs (miRNAs), as gene expression regulators, have been identified to be closely associated with tumorigenesis. Thus a loss-of-function study is more likely to reveal the biological roles of endogenous miRNAs. Genetic knockout, antisense oligonucleotide inhibitors, and miRNA sponge (miR‑SP) are usually performed ...

journal_title：Oncology reports

authors： Ma J,Wu Q,Zhang Y,Li J,Yu Y,Pan Q,Sun F

更新日期：2014-12-01 00:00:00

abstract：:Gelatinases play an important role in tumor growth and metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. Lidamycin is an enediyne antitumor antibiotic with potent cytotoxicity. We previously reported that a...

journal_title：Oncology reports

authors： Zhong GS,Wu MN,Guo XF,Zhang SH,Miao QF,Zhen YS

更新日期：2012-10-01 00:00:00

abstract：:Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...

journal_title：Oncology reports

authors： Ai F,Zhao G,Lv W,Liu B,Lin J

更新日期：2020-02-01 00:00:00

abstract：:Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...

journal_title：Oncology reports

authors： Hu CF,Huang YY,Wang YJ,Gao FG

更新日期：2016-07-01 00:00:00

abstract：:Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...

journal_title：Oncology reports

authors： Deng L,Fan J,Ding Y,Zhang J,Zhou B,Zhang Y,Huang B,Hu Z

更新日期：2019-01-01 00:00:00

abstract：:v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EM...

journal_title：Oncology reports

authors： Li C,Wang Z,Chen Y,Zhou M,Zhang H,Chen R,Shi F,Wang C,Rui Z

更新日期：2015-02-01 00:00:00

abstract：:The aims of the present study were to review the experience of different surgical reconstruction methods for hypopharyngeal squamous cell carcinoma (HSCC) and compared the survival of patients with and without laryngeal function (LF) preservation. The clinical characteristics of 580 patients were retrospectively obtai...

journal_title：Oncology reports

authors： Zhou J,Li Y,Wei D,Qian Y,Li W,Liu D,Li G,Pan X,Lei D

更新日期：2015-12-01 00:00:00

abstract：:The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital...

journal_title：Oncology reports

authors： Sato M,Kawana K,Adachi K,Fujimoto A,Taguchi A,Fujikawa T,Yoshida M,Nakamura H,Nishida H,Inoue T,Ogishima J,Eguchi S,Yamashita A,Tomio K,Arimoto T,Wada-Hiraike O,Oda K,Nagamatsu T,Osuga Y,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....

journal_title：Oncology reports

authors： Wang N,Wei L,Huang Y,Wu Y,Su M,Pang X,Wang N,Ji F,Zhong C,Chen T,Li B

更新日期：2017-03-01 00:00:00

abstract：:WNT/planar cell polarity (PCP) signaling pathway controls tissue polarity and cell movement through the activation of RHOA, c-Jun N-terminal kinase (JNK), and nemo-like kinase (NLK) signaling cascades. PCP is induced in Drosophila by the asymmetrical localization of Frizzled-Dishevelled-Diego-Starry night (Flamingo) c...

journal_title：Oncology reports

authors： Katoh M

更新日期：2005-12-01 00:00:00

abstract：:The tumor necrosis factor receptor (TNFR)-associated factor 4 (TRAF4) is a member of TRAF family proteins that act as major signal transducers of the TNF receptor and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAF4 has been reported to be overexpressed in various human cancers. However, th...

journal_title：Oncology reports

authors： Ahmed F,Shiraishi T,Vessella RL,Kulkarni P

更新日期：2013-12-01 00:00:00

abstract：:Identification of novel botanicals that can selectively induce apoptosis and arrest growth of cancer cells without producing cytotoxic effects is highly appreciable for cancer therapy. The present study aimed to investigate the possibility of acetylbritannilactone (ABL) derivative 5-(5-(ethylperoxy)pentan-2-yl)-6-meth...

journal_title：Oncology reports

authors： Zhang Y,Liu K,Zhang Y,Qi J,Lu B,Shi C,Yin Y,Cai W,Li W

更新日期：2015-12-01 00:00:00

abstract：:High mobility group N (HMGNs) are members of the high mobility group protein family, and are involved in the development and progression of several tumors. HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma. However, the effects and molecular mechanisms of HMGN2 on osteosarco...

journal_title：Oncology reports

authors： Liang G,Xu E,Yang C,Zhang C,Sheng X,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross...

journal_title：Oncology reports

authors： Li M,Chen R,Ji B,Fan C,Wang G,Yue C,Jin G

更新日期：2021-01-14 00:00:00

abstract：:Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...

journal_title：Oncology reports

authors： Corrêa NC,Kuasne H,Faria JA,Seixas CC,Santos IG,Abreu FB,Nonogaki S,Rocha RM,Aparecida Borges Silva G,Gobbi H,Rogatto SR,Goes AM,Gomes DA

更新日期：2013-04-01 00:00:00

abstract：:Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fluorouracil (5-FU) i...

journal_title：Oncology reports

authors： Okada K,Hakata S,Terashima J,Gamou T,Habano W,Ozawa S

更新日期：2016-10-01 00:00:00