Abstract：
CASE (DESCRIPTION):We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes. CONCLUSION:Our results may suggest a role of the UGT2B7-372A>G polymorphism in this reaction.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Provenzani A,Labbozzetta M,Notarbartolo M,Poma P,Polidori P,Vizzini G,D'Alessandro Ndoi
10.1007/s11096-015-0158-4subject
Has Abstractpub_date
2015-10-01 00:00:00pages
682-6issue
5eissn
2210-7703issn
2210-7711pii
10.1007/s11096-015-0158-4journal_volume
37pub_type
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journal_title：International journal of clinical pharmacy
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pub_type： 已发布勘误
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