A possible effect of montelukast on neurological aging examined by the use of register data.

Abstract:

:Background The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. Method The present observational study was based on data from the Norwegian Prescription Database and the Tromsø Study. The former has information regarding the use of prescription medicine; the latter includes tests for brain function such as subjective memory and finger-tapping. Multivariate linear regression analyses were performed to see how the use of various medications correlated with the test results, correcting for likely confounders. Main outcome measure Results on seven different tests considered relevant for neurological health were used as outcome. Results Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F = 2.20, p = 0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging.

journal_name

Int J Clin Pharm

authors

Grinde B,Schirmer H,Eggen AE,Aigner L,Engdahl B

doi

10.1007/s11096-020-01160-8

subject

Has Abstract

pub_date

2020-10-09 00:00:00

eissn

2210-7703

issn

2210-7711

pii

10.1007/s11096-020-01160-8

pub_type

杂志文章
  • Prevalence and predictors of potentially inappropriate medications among home care elderly patients in Qatar.

    abstract:BACKGROUND:Older patients receiving home health care are particularly at risk of receiving potentially inappropriate medications compared to community-dwelling population. Data on appropriateness of prescribing in these patients is limited. OBJECTIVE:To investigate the prevalence, patterns and determinants of potentia...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-015-0125-0

    authors: Alhmoud E,Khalifa S,Bahi AA

    更新日期:2015-10-01 00:00:00

  • Quality of drug information database research for clinical decision support.

    abstract::This commentary identifies studies that have compared commercially available DI databases, and discusses improvements in study methodology that might better guide clinicians in selecting resources for their practice setting. We also provide suggestions for future direction of research in this area with an eye towards ...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章,评审

    doi:10.1007/s11096-011-9522-1

    authors: Hoody DW,Beckett CF,Zielenski C,Moore GD

    更新日期:2011-08-01 00:00:00

  • Prescribing omissions in elderly patients admitted to a stroke unit: descriptive study using START criteria.

    abstract:BACKGROUND:Underuse of medication considered beneficial is particularly common in elderly patients. A new Screening Tool to Alert Doctors to the Right Treatment (START) has been published to identify potential prescribing omissions. OBJECTIVE:To quantify and characterize potential prescribing omissions of cardiovascul...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-012-9635-1

    authors: Borges EP,Morgado M,Macedo AF

    更新日期:2012-06-01 00:00:00

  • Development and psychometric testing of the medication taking behavior tool in Thai patients.

    abstract:BACKGROUND:The previous Thai version of the 8-item Morisky Medication Adherence Scale (8-item MMAS) showed poor sensitivity and unacceptable internal consistency reliability. OBJECTIVES:To develop and test the psychometric properties of a new medication taking behavior measure for Thai patients (MTB-Thai) including pr...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11096-016-0275-8

    authors: Sakthong P,Sonsa-Ardjit N,Sukarnjanaset P,Munpan W,Suksanga P

    更新日期:2016-04-01 00:00:00

  • Community pharmacists' clinical reasoning: a protocol analysis.

    abstract::Background There are two fundamental approaches to clinical reasoning, intuitive and analytical. These approaches have yet to be well explored to describe how pharmacists make decisions to determine medication appropriateness. Objective (1) to identify the cognitive actions (i.e., operators) that pharmacists employ wh...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-019-00906-3

    authors: Nusair MB,Cor MK,Roduta Roberts M,Guirguis LM

    更新日期:2019-12-01 00:00:00

  • Predictors of non-adherence to pharmacotherapy in patients with type 2 diabetes.

    abstract:BACKGROUND:The prevalence of diabetes in Jordan is among the highest in the world, making it a particularly alarming health problem there. It has been indicated that poor adherence to the prescribed therapy lead to poor glycemic control and enhance the development of diabetes complications and unnecessary hospitalizati...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-014-9938-5

    authors: Jarab AS,Almrayat R,Alqudah S,Thehairat E,Mukattash TL,Khdour M,Pinto S

    更新日期:2014-08-01 00:00:00

  • Drug allergy documentation--time for a change?

    abstract:OBJECTIVE OF THE STUDY:To audit patients' allergy documentation in a large rural hospital an to make recommendations about accurate drug allergies in hospital settings. SETTING:A 257 bed large hospital and fully integrated health service in Australia, providing a range of services including; medicine, surgery, aged ca...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11096-011-9525-y

    authors: Khalil H,Leversha A,Khalil V

    更新日期:2011-08-01 00:00:00

  • Medication use during end-of-life care in a palliative care centre.

    abstract:BACKGROUND:In end-of-life care, symptoms of discomfort are mainly managed by drug therapy, the guidelines for which are mainly based on expert opinions. A few papers have inventoried drug prescriptions in palliative care settings, but none has reported the frequency of use in combination with doses and route of adminis...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-015-0094-3

    authors: Masman AD,van Dijk M,Tibboel D,Baar FP,Mathôt RA

    更新日期:2015-10-01 00:00:00

  • Balancing traditional activities and cognitive pharmaceutical services by community pharmacists: a work sampling study.

    abstract::Background Community pharmacy is undergoing a transition, shifting focus from traditional roles to the provision of cognitive pharmaceutical services. However, traditional activities performed by community pharmacists reduce the amount of available time for implementing and providing such services. Therefore, hamperin...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-019-00852-0

    authors: van de Pol J,Koster E,Hövels A,Bouvy M

    更新日期:2019-08-01 00:00:00

  • Doctors' perceptions, expectations and experience regarding the role of pharmacist in hospital settings of Pakistan.

    abstract::Background The inclusion of pharmacist in health care system is essential to ensure optimal patient care. However, with the passage of time, pharmacist's role has transcended from dispensing, compounding and counting of pills, to more sophisticated clinical duties. Objective To evaluate doctors' experience, perception...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-020-00991-9

    authors: Khan N,McGarry K,Naqvi AA,Holden K

    更新日期:2020-04-01 00:00:00

  • Prescribing pattern of antihypertensive drugs in a general hospital in central China.

    abstract:OBJECTIVES:To examine the prescribing pattern of antihypertensive drugs in outpatients with hypertension in a general hospital in central China and identify whether the pattern of prescribing is appropriate and in accordance with national and international guidelines for pharmacotherapy of hypertension. SETTING:The in...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-010-9476-8

    authors: Cheng H

    更新日期:2011-04-01 00:00:00

  • Validation of the Lebanese Medication Adherence Scale among Lebanese diabetic patients.

    abstract::Background Adherence to oral antidiabetics plays a pivotal role in controlling diabetes. Healthcare workers evaluate this adherence when visited by patients. Objectives The primary objective of this study was to validate the existing LMAS-14 (Lebanese Medication Adherence Scale) in Lebanese diabetic adults. The second...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-020-01197-9

    authors: Ibrahim L,Ibrahim L,Hallit S,Salameh P,Sacre H,Akel M,Bou Serhal R,Saleh N

    更新日期:2020-11-17 00:00:00

  • Drug related problems identified by community pharmacists on hospital discharge prescriptions in New Zealand.

    abstract:BACKGROUND:There can be a lack of transfer of information between hospitals and community pharmacies following patient discharge, which puts patients at a high risk of suffering drug related problems (DRPs). Community pharmacy plays a vital role in identifying and solving these discharge DRPs and taking action before t...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-014-9935-8

    authors: Braund R,Coulter CV,Bodington AJ,Giles LM,Greig AM,Heaslip LJ,Marshall BJ

    更新日期:2014-06-01 00:00:00

  • Dose calculation in opioid rotation: electronic calculator vs. manual calculation.

    abstract:OBJECTIVE:To generate, validate and establish a web-based individualised opioid conversion calculator at the University Hospital Basel and to analyse its value and significance. SETTING:A 700-bed university hospital. METHOD:Published data were screened by a Medline search using the keywords: opioid, rotation, switchi...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-010-9464-z

    authors: Plagge H,Ruppen W,Ott N,Fabbro T,Bornand D,Deuster S

    更新日期:2011-02-01 00:00:00

  • Unintentional and intentional non-adherence to immunosuppressive medications in renal transplant recipients.

    abstract::Background Non-adherence to immunosuppressive medications following renal transplantation is a risk factor for rejection and graft loss. Despite the dire consequences, adherence lapses, both unintentional and intentional, are common and poorly understood. Objective The present study sets to compare the rates and deter...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-018-0652-6

    authors: Griva K,Neo HLM,Vathsala A

    更新日期:2018-10-01 00:00:00

  • Pharmacists' knowledge and interest in developing counseling skills relating to oral contraceptives.

    abstract:BACKGROUND:Possessing correct therapeutic information on oral contraceptives is an important prerequisite for the provision of sound advice to women who are using these products. OBJECTIVES:This study examines Egyptian pharmacists' knowledge of pharmacotherapeutic aspects of oral contraceptives as well as interest in ...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-016-0264-y

    authors: Amin ME

    更新日期:2016-04-01 00:00:00

  • Impact of an oral nutrition protocol in patients treated with elective radical cystectomy: a long term follow-up.

    abstract::Background After radical cystectomy, delayed return of bowel function is relatively common. Although studies investigating on the best modality for delivering nutritional support to this patient group are limited, parenteral nutrition was standard of care in those patients at the urological ward of the University Hosp...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-019-00800-y

    authors: Declercq P,Van der Aa F,De Pourcq L,Spriet I

    更新日期:2019-04-01 00:00:00

  • A combined nurse-pharmacist managed pain clinic: joint venture of public and private sectors.

    abstract::Chronic pain has become one of the most prevalent problems in primary care. The management of chronic pain is complex and often requires a multidisciplinary approach. The limited capacity of general practitioners to manage chronic pain and long waiting time for secondary care referrals further add to the complexity of...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-011-9591-1

    authors: Hadi MA,Alldred DP,Briggs M,Closs SJ

    更新日期:2012-02-01 00:00:00

  • Screening for impaired liver function as a risk factor for drug safety at hospital admission of surgical patients.

    abstract::Background Hepatic insufficiency can affect patient safety and should therefore be considered during drug therapy. Hospital admission offers an ideal point to screen for patients at risk and to adjust drug therapy accordingly. Objective To assess the number of patients admitted to hospital with clinically elevated liv...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-019-00948-7

    authors: Strobach D,Poppele A,Mannell H,Andraschko M,Schiek S,Bertsche T

    更新日期:2020-02-01 00:00:00

  • Knowledge and attitude of health-care professionals in hospitals towards pharmacovigilance in Saudi Arabia.

    abstract:BACKGROUND:Drug safety has major implications for patients' lives. However, this concept is still considered new to some healthcare professionals. OBJECTIVE:This study aims to investigate the knowledge and awareness of Saudi healthcare professionals to pharmacovigilance (PV). Setting Governmental and private hospitals...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-015-0165-5

    authors: Alshammari TM,Alamri KK,Ghawa YA,Alohali NF,Abualkol SA,Aljadhey HS

    更新日期:2015-12-01 00:00:00

  • A cross-sectional evaluation of community pharmacists' perceptions of intermediate care and medicines management across the healthcare interface.

    abstract::Background Despite the importance placed on the concept of the multidisciplinary team in relation to intermediate care (IC), little is known about community pharmacists' (CPs) involvement. Objective To determine CPs' awareness of and involvement with IC services, perceptions of the transfer of patients' medication inf...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-016-0377-3

    authors: Millar A,Hughes C,Devlin M,Ryan C

    更新日期:2016-12-01 00:00:00

  • Adherence to tyrosine kinase inhibitors among adult chronic myeloid leukemia patients in a Malaysia hospital.

    abstract::Background Tyrosine kinase inhibitors have been demonstrated to improve the survival of patients with chronic myeloid leukaemia. However, medication adherence is vital for patients on chronic treatment. Objective The objective of the current study was to evaluate response to treatment, adherence by patients to tyrosin...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-020-01070-9

    authors: Lee PM,Chang CT,Yusoff ZM

    更新日期:2020-06-11 00:00:00

  • Health-related quality of life of exposed versus non-exposed androgen deprivation therapy patients with prostate cancer: a cross-sectional study.

    abstract::Background The survival rate of prostate cancer is relatively higher than other cancers, therefore, the health-related quality of life (HRQoL) becomes a critical issue for the patients. There are limited quality of life data evaluating the difference between androgen deprivation therapy and non-androgen deprivation th...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-019-00854-y

    authors: Huang YT,Li CC,Chou YH,Ke HL,Chen CY

    更新日期:2019-08-01 00:00:00

  • Outcomes of ceftriaxone use compared to standard of therapy in methicillin susceptible staphylococcal aureus (MSSA) bloodstream infections.

    abstract:BACKGROUND:Standard of care therapy (SOCT) for the treatment of methicillin susceptible staphylococcal aureus (MSSA) infections requires multiple daily infusions. Despite questionable efficacy due to high protein binding, ceftriaxone (CTX) is frequently used for treatment of MSSA at Hines VA Hospital. OBJECTIVE:The ob...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-014-9999-5

    authors: Patel UC,McKissic EL,Kasper D,Lentino JR,Pachucki CT,Lee T,Lopansri BK

    更新日期:2014-12-01 00:00:00

  • Controversy and consensus on a clinical pharmacist in primary care in the Netherlands.

    abstract:UNLABELLED:Background Controversy about the introduction of a non-dispensing pharmacist in primary care practice hampers implementation. Objective The aim of this study is to systematically map the debate on this new role for pharmacists amongst all stakeholders to uncover and understand the controversy and consensus. ...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-016-0360-z

    authors: Hazen AC,Wal AW,Sloeserwij VM,Zwart DL,Gier JJ,Wit NJ,Leendertse AJ,Bouvy ML,Bont AA

    更新日期:2016-10-01 00:00:00

  • Adverse drug reactions experience in a teaching hospital in Jordan.

    abstract:BACKGROUND:Adverse drug reactions (ADRs) represent a major health care problem. OBJECTIVE:To identify the most common ADRs, drugs implicated in ADRs, and to assess their causality, severity, preventability and risk factors predisposing to reported ADRs in Jordan. SETTING:Al-Karak teaching hospital, southern of Jordan...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-015-0185-1

    authors: Alsbou M,Alzubiedi S,Alzobi H,Samhadanah NA,Alsaraireh Y,Alrawashdeh O,Aqel A,Al-Salem K

    更新日期:2015-12-01 00:00:00

  • Adherence and satisfaction with oral hypoglycemic medications: a pilot study in Palestine.

    abstract:OBJECTIVES:Diabetes mellitus is a chronic progressive disease characterized by numerous health complications. Medication adherence is an important determinant of therapeutic outcome. Few studies on medication adherence have been published from the Arab countries. Therefore, the objective of this pilot study was to asse...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-011-9561-7

    authors: Jamous RM,Sweileh WM,Abu-Taha AS,Sawalha AF,Zyoud SH,Morisky DE

    更新日期:2011-12-01 00:00:00

  • Adverse drug reaction reporting in the Czech Republic 2005-2009.

    abstract:OBJECTIVE:The aim of this study was to assess the situation regarding spontaneous adverse drug reaction reporting in the Czech Republic during a 5-year period (2005-2009). SETTING:Descriptive study was conducted using the data from the Czech State Institute for Drug Control pharmacovigilance database. METHODS:The dat...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-011-9527-9

    authors: Kopečná E,Deščíková V,Vlček J,Mladá J

    更新日期:2011-08-01 00:00:00

  • Evaluation of the effect of acetazolamide versus mannitol on cisplatin-induced nephrotoxicity, a pilot study.

    abstract::Background Cisplatin-induced nephrotoxicity still occurs despite the intensive hydration approach adapted to prevent its occurrence. Objective Evaluation of the effect of acetazolamide (ACTZ) on minimizing cisplatin-induced nephrotoxicity compared to mannitol when added to hydration regimen. Setting Nasser Institute C...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-018-0677-x

    authors: El Hamamsy M,Kamal N,Bazan NS,El Haddad M

    更新日期:2018-12-01 00:00:00

  • Use of the Delphi technique to determine safety features to be included in a neonatal and paediatric prescription chart.

    abstract:BACKGROUND:Neonatal and paediatric patients are especially vulnerable to serious injury as a result of medication errors due to their small size, physiological immaturity and limited compensatory abilities. The prescription chart remains an essential form of communication of prescribing decisions and instructions. Modi...

    journal_title:International journal of clinical pharmacy

    pub_type: 杂志文章

    doi:10.1007/s11096-014-0014-y

    authors: Cassar Flores A,Marshall S,Cordina M

    更新日期:2014-12-01 00:00:00