Abstract：
:Background The direct oral anticoagulants (DOACs) offer several advantages over warfarin in the management atrial fibrillation, including the provision of fixed dosing without a requirement for regular monitoring. Recently however the subject of DOAC monitoring has been probed after several post-hoc analyses demonstrated an association between plasma levels and efficacy and safety events. Objective The aim of this pilot study was to explore the acceptability of DOAC plasma monitoring amongst patients with atrial fibrillation and the factors that may influence these attitudes. Method A simple DOAC monitoring schedule based on the dabigatran pharmacokinetic profile was developed. A cross-sectional survey was distributed to patients with atrial fibrillation asking them to indicate their likelihood of taking a particular DOAC subjected to plasma monitoring. Results Thirty patients participated in the study. Most patients (63.3%) favoured taking a DOAC subjected to monitoring under the proposed schedule, citing increased efficacy and reduced toxicity as the reasons for their response. Conclusion There is some suggestion that atrial fibrillation patients may in fact favour taking a DOAC subjected to infrequent monitoring if this enhanced safety and efficacy.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Mourad AP,Aslani P,D'Souza M,Brieger Ddoi
10.1007/s11096-019-00830-6subject
Has Abstractpub_date
2019-06-01 00:00:00pages
682-686issue
3eissn
2210-7703issn
2210-7711pii
10.1007/s11096-019-00830-6journal_volume
41pub_type
杂志文章abstract：:Background Community pharmacy is undergoing a transition, shifting focus from traditional roles to the provision of cognitive pharmaceutical services. However, traditional activities performed by community pharmacists reduce the amount of available time for implementing and providing such services. Therefore, hamperin...
journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Linezolid represents an important advance in the treatment of methicillinresistant staphylococci. Its effectiveness should be preserved by appropriate uses. The aims of this survey were to describe the use of linezolid in clinical practice and to assess its overall safety. METHODS:This retrospective observat...
journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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更新日期：2018-02-01 00:00:00
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journal_title：International journal of clinical pharmacy
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更新日期：2018-04-01 00:00:00
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journal_title：International journal of clinical pharmacy
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journal_title：International journal of clinical pharmacy
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更新日期：2015-02-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：International journal of clinical pharmacy
pub_type： 杂志文章
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