Abstract:
BACKGROUND:Bleeding complications have been frequently reported in East Asian patients on warfarin with a target international normalized ratio (INR) of 2.0-3.0. OBJECTIVE:This study aimed to identify the optimal therapeutic range of the INR in Korean patients with non-valvular atrial fibrillation (NVAF). Setting Cardiovascular department of a 1320 inpatient bed Korean hospital. METHOD:Retrospective chart review was conducted on 1014 patients for a total follow-up period of 2249.2 patient years. Major thromboembolic and bleeding complications were evaluated. The INR incidence of complication curve was plotted, and the optimal therapeutic range of INR was determined from the intersection of curves to ensure the lowest incidences of both thromboembolic and bleeding complications. For subgroup analysis, all patients were stratified by the following factors: age (above 75), disease (presence of hypertension, diabetes, congestive heart failure, and a history of stroke or thromboembolism), rhythm control procedure, and concurrent aspirin therapy. Main outcome measure Optimal therapeutic ranges of INR according to the risk factors. RESULTS:A total of 41 thromboembolic and 91 bleeding events occurred during the follow-up period. The complication rates were the lowest at an INR of 1.9 and the optimal therapeutic range was estimated to be 1.7-2.2 for the overall patients. The optimal therapeutic ranges of INR in the stratified patients were determined as follows: 1.3-1.8 in the patients ≥75 years of age; 1.5-2.0 in patients with hypertension, diabetes and concurrent aspirin therapy; 1.8-2.3 in patients with congestive heart failure; 1.9-2.4 in patients with previous stroke or thromboembolism; 1.7-2.2 in patients who had undergone rhythm control procedures. It has been shown that, by keeping the INR within these ranges, complication risks could be significantly reduced by up to 81 %. CONCLUSION:The intensity of anticoagulation therapy for Korean patients with NVAF is optimal when INR is between 1.7 and 2.2.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Chung JE,Choi YR,Seong JM,La HO,Gwak HSdoi
10.1007/s11096-015-0149-5subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1038-46issue
6eissn
2210-7703issn
2210-7711pii
10.1007/s11096-015-0149-5journal_volume
37pub_type
杂志文章abstract::Background Taking regular medication has been shown to have an impact on the daily lives of patients and their families. Objective To explore the medication-related experiences of patients and their families when a child or young person is prescribed regular medication. Setting A specialist U.K. paediatric hospital. M...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0756-z
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Granulocyte colony-stimulating factor administration is an important component of supportive therapy in chemotherapy-induced leukopenia. Although patient response to granulocyte colony-stimulating factor administration is known to vary, the factors responsible for poor response have not been identified. OBJ...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-012-9703-6
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:In September 2007, the FDA issued an alert recommending that ceftriaxone and calcium-containing solutions should not be administered to any patient within 48 h of each other. Due to the widespread use of ceftriaxone, significant concern was expressed by the greater healthcare community about the warning, whic...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-011-9503-4
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Diabetes mellitus is a chronic progressive disease characterized by numerous health complications. Medication adherence is an important determinant of therapeutic outcome. Few studies on medication adherence have been published from the Arab countries. Therefore, the objective of this pilot study was to asse...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-011-9561-7
更新日期:2011-12-01 00:00:00
abstract::Background Implementation of clinical medication reviews in daily practice is scarcely evaluated. The Opti-Med intervention applied a structured approach with external expert teams (pharmacist and physician) to conduct medication reviews. The intervention was effective with respect to resolving drug related problems, ...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0615-y
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The growth of pharmaceutical expenditure and patients' out of pocket has motivated policy makers to encourage patients to substitution of brands medicines with their generic alternatives called generic substitution. OBJECTIVES:As the patients are final decision makers to accept generic substitution, the aim...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0085-4
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:There has been little research which specifically examines medicine use among South Asian (SA) and Middle Eastern (ME) groups, although evidence suggests that medicine-related needs may be poorly met for these groups. OBJECTIVE:To describe medicine-related problems (MRPs) experienced by SA and ME patients f...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0103-6
更新日期:2015-08-01 00:00:00
abstract::Background Chronic pain is a prevalent and debilitating condition for many people. Globally it is the greatest contributor to years lived with disability. Management often includes pharmacotherapy and pharmacists are therefore well placed to contribute to chronic pain management. Objective To explore chronic pain mana...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-01198-8
更新日期:2020-11-27 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-011-9576-0
更新日期:2011-12-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,meta分析
doi:10.1007/s11096-018-0641-9
更新日期:2018-06-01 00:00:00
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journal_title:International journal of clinical pharmacy
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doi:10.1007/s11096-012-9635-1
更新日期:2012-06-01 00:00:00
abstract::Background Parkinson's disease is the second most common neurodegenerative disorder. Motor and non-motor symptoms seem to precede the diagnosis of Parkinson's disease. Objective To evaluate the incidence of muscle relaxant use in community-dwelling persons with and without Parkinson's disease from 4 years before to 4 ...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-01002-7
更新日期:2020-04-01 00:00:00
abstract:UNLABELLED:Sequential antimicrobial therapy is an important part of antimicrobial stewardship and intends to improve the timeliness of switch to oral antimicrobials. The aim of this study was to assess the impact of the introduction of guidelines and criteria for switching to oral antimicrobials. SETTING:The study was...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-010-9475-9
更新日期:2011-04-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0185-1
更新日期:2015-12-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-012-9708-1
更新日期:2013-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-013-9863-z
更新日期:2013-10-12 00:00:00
abstract:BACKGROUND:Replacement therapy in haemophilia plays an important role in the effective management of this rare bleeding disorder and requires a high level of knowledge and practical skills. OBJECTIVE:To evaluate and to compare the knowledge and skills about the medicines and their management among people with haemophi...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,多中心研究
doi:10.1007/s11096-015-0207-z
更新日期:2016-02-01 00:00:00
abstract::Background There is a lack of data on the prevalence of potentially inappropriate medications (PIMs) in community-dwelling older adults in China. Objective To assess the prevalence of potentially inappropriate medication in community dwelling older adults in China and to investigate risk factors associated with the us...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-00980-y
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE OF THE STUDY:To audit patients' allergy documentation in a large rural hospital an to make recommendations about accurate drug allergies in hospital settings. SETTING:A 257 bed large hospital and fully integrated health service in Australia, providing a range of services including; medicine, surgery, aged ca...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11096-011-9525-y
更新日期:2011-08-01 00:00:00
abstract::Background Despite the importance placed on the concept of the multidisciplinary team in relation to intermediate care (IC), little is known about community pharmacists' (CPs) involvement. Objective To determine CPs' awareness of and involvement with IC services, perceptions of the transfer of patients' medication inf...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-016-0377-3
更新日期:2016-12-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-013-9798-4
更新日期:2013-10-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-014-9915-z
更新日期:2014-04-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-01221-y
更新日期:2021-01-07 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-017-0567-7
更新日期:2018-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0595-y
更新日期:2018-04-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-014-0048-1
更新日期:2015-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,评审
doi:10.1007/s11096-019-00833-3
更新日期:2019-08-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-019-00800-y
更新日期:2019-04-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0714-9
更新日期:2018-10-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-01197-9
更新日期:2020-11-17 00:00:00