当前位置： SCI文献检索 > Taiwanese Journal of Obstetrics & Gynecology期刊下所有文献 > Toxicity of intraperitoneal chemotherapy and risk factors for severe toxicity in optimally debulked ovarian cancer patients.

Toxicity of intraperitoneal chemotherapy and risk factors for severe toxicity in optimally debulked ovarian cancer patients.

Abstract：

OBJECTIVE:To assess the effect and toxicity of intraperitoneal (IP) chemotherapy for epithelial ovarian cancer and to determine the risk factors for severe toxicity. MATERIALS AND METHODS:Patients who received IP chemotherapy after optimal debulking surgery for ovarian cancer between 2006 and 2012 were retrospectively reviewed. Clinical characteristics were compared between patients with none/Grade 1 or Grade 2 toxicity and those with Grade 3 or Grade 4 toxicity. RESULTS:In 41 patients, the mean number of IP cycles administered was 5.6 and most patients (80.5%) completed at least six cycles. The reasons for discontinuation were catheter-related problems (30%), disease progression (20%), or drug-related adverse effects (30%). Grade 3 or Grade 4 toxicity was observed in 30 patients (73.2%). The rate of neoadjuvant chemotherapy was higher in the patients with Grade 3 or Grade 4 toxicity (37%) than in the patients without Grade 3 or Grade 4 toxicity (9%), however, this difference was not significant (p = 0.128). During a mean follow-up period of 33.6 months, tumor recurrence occurred in 20 (48.8%) patients and the median progression-free survival was 30.0 months. CONCLUSION:Despite the high rate of adverse events, IP chemotherapy can be delivered with a high completion rate and manageable toxicity to patients with optimally debulked ovarian cancer. Toxicity should be closely monitored in patients who have received neoadjuvant chemotherapy until a large prospective study can be performed to determine its influence.

journal_name

Taiwan J Obstet Gynecol

journal_title

Taiwanese journal of obstetrics & gynecology

authors

Koo YJ,Lim KT

doi

10.1016/j.tjog.2013.12.010

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

275-9

issue

3

eissn

1028-4559

issn

1875-6263

pii

S1028-4559(15)00078-9

journal_volume

54

pub_type

杂志文章

相关文献

Taiwanese Journal of Obstetrics & Gynecology文献大全
  • Successful treatment of placenta accreta spectrum disorder using management strategy of serial uterine artery embolization combined with standard weekly and a 8-day methotrexate/folinic acid regimens at 7 weeks of gestation.

    abstract：OBJECTIVE:We describe our experience with serial uterine artery embolization (UAE) combined with standard weekly methotrexate and a eight-day methotrexate/folinic acid (MTX/FA) treatment regimen in the management of placenta accreta spectrum (PAS) disorder at 7 weeks of gestation. CASE REPORT:A 38-year-old woman, grav...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type：

    doi：10.1016/j.tjog.2020.09.027

    authors： Chou MM,Yuan JC,Lu YA,Chuang SW

    更新日期：2020-11-01 00:00:00

  • The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer.

    abstract：OBJECTIVE:Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC). MATERIALS A...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2018.02.015

    authors： Sung PL,Wen KC,Horng HC,Chang CM,Chen YJ,Lee WL,Wang PH

    更新日期：2018-04-01 00:00:00

  • Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding.

    abstract：OBJECTIVES:The feasibility of vaginoscopic hysteroscopy combined with office endometrial biopsy after ultrasonography for management of post-menopausal vaginal bleeding (PMB). MATERIALS AND METHODS:A prospective observational study of with PMB whom attending the Outpatient Clinic of Kang Ning Hospital during a four mo...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2019.05.012

    authors： Lee YL,Bai YS,Yin CS

    更新日期：2019-07-01 00:00:00

  • Factors influencing the abortion interval of second trimester pregnancy termination using misoprostol.

    abstract：OBJECTIVES:To determine the factors influencing the abortion interval (AI) for medical termination of second-trimester pregnancy using misoprostol. MATERIALS AND METHODS:All patients who were admitted for second-trimester pregnancy termination between January 2008 and August 2013 were reviewed. Those who received eith...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.08.008

    authors： Ting WH,Peng FH,Lin HH,Lu HF,Hsiao SM

    更新日期：2015-08-01 00:00:00

  • Preeclampsia is associated with low placental transthyretin levels.

    abstract：OBJECTIVE:To investigate the relationship between placental transthyretin (TTR) level and preeclampsia. MATERIALS AND METHODS:Placental tissues from uncomplicated and preeclamptic pregnancies were analyzed using immunohistochemistry and image analysis. We measured the mean optical density (OD) of immunohistochemical s...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.04.014

    authors： Zhu L,Baczyk D,Lye SJ,Zhang Z

    更新日期：2016-06-01 00:00:00

  • Embryo splitting can increase the quantity but not the quality of blastocysts.

    abstract：OBJECTIVE:In this study, we investigated the developmental potential of single blastomeres that were obtained from 4-cell mice embryos that were split during the blastocyst stage. MATERIALS AND METHODS:Imprinting Control Region (ICR) mice (age: 6-8 weeks), were superovulated and mated with a single fertile male of the...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2012.04.012

    authors： Tang HH,Tsai YC,Kuo CT

    更新日期：2012-06-01 00:00:00

  • A survey of judicial decisions concerning surrogacy disputes in Taiwan.

    abstract：OBJECTIVE:Currently, Taiwan's Artificial Reproduction Act denies the legality of practicing surrogacy in Taiwan. The fact that numerous intended parents access surrogacy through fertility tourism or illegal practice leads to various types of disputes. This article illustrates the types of surrogacy-related disputes in ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2018.06.006

    authors： Chiang WT,Chou TY

    更新日期：2018-08-01 00:00:00

  • Double-balloon cervical ripening catheter works well as an intrauterine balloon tamponade in post-abortion massive hemorrhage.

    abstract：OBJECTIVE:Clinical experience in the management of post-abortion hemorrhage is limited. CASE REPORTS:Two women with severe post-abortion hemorrhage were reported. One case occurred after methotrexate treatment of Cesarean scar pregnancy and the other occurred after abortion surgery. Both patients were successfully tre...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2012.07.020

    authors： Tsui KH,Lin LT,Yu KJ,Chen SF,Chang WH,Yu S,Cheng JT,Wang PH

    更新日期：2012-09-01 00:00:00

  • Prenatal 2D ultrasonic diagnosis of fetal complete atrioventricular block and bilateral hydroceles with occult maternal SS-A.

    abstract：OBJECTIVE:We present a case of fetal complete atrioventricular block, diagnosed by the M mode of two-dimensional ultrasound, that was complicated with polyhydramnios and bilateral hydrocele. CASE REPORT:The fetus was delivered at 38 weeks' gestation by caesarean section. Postpartum autoimmune survey disclosed positive...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/s1028-4559(09)60192-3

    authors： Chen CY,Wu YC,Yang ML

    更新日期：2006-03-01 00:00:00

  • The effect of HPV infection on a couple's relationship: a qualitative study in Taiwan.

    abstract：OBJECTIVE:The purpose of this study is to explore the effect of human papillomavirus (HPV) on the sexual lives of women and their partners. MATERIALS AND METHODS:Twenty oncogenic or high-risk HPV infected cases were collected via purposive sampling. At a tertiary medical center in Taipei, 20 women underwent a 2-hour i...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(10)60090-3

    authors： Jeng CJ,Lin H,Wang LR

    更新日期：2010-12-01 00:00:00

  • Molecular cytogenetic characterization of Xp22.32→pter deletion and Xq26.3→qter duplication in a male fetus associated with 46,Y,rec(X)dup(Xq) inv(X)(p22.3q26.3), a hypoplastic left heart, short stature, and maternal X chromosome pericentric inversion.

    abstract：OBJECTIVE:We present molecular cytogenetic characterization of an Xp22.32→pter deletion and an Xq26.3→qter duplication in a male fetus with congenital malformations and maternal X chromosome pericentric inversion. MATERIALS AND METHODS:A 22-year-old woman underwent amniocentesis at 17 weeks of gestation because of an ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.05.009

    authors： Chen CP,Chen CY,Chern SR,Wu PS,Chen YN,Chen SW,Lee CC,Town DD,Lee MS,Yang CW,Wang W

    更新日期：2016-10-01 00:00:00

  • Analyses of placental gene expression in pregnancy-related hypertensive disorders.

    abstract：OBJECTIVE:To explore the changes in placental gene expression between women with preeclampsia and those with superimposed preeclampsia on chronic hypertension. MATERIALS AND METHODS:In Taiwanese population, we compared gene expression between the placentas from preeclamptic patients and those with superimposed preecla...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2011.07.005

    authors： Chang SD,Chao AS,Peng HH,Chang YL,Wang CN,Cheng PJ,Lee YS,Chao A,Wang TH

    更新日期：2011-09-01 00:00:00

  • Factors associated with post-partum smoking relapse in Taiwan: A trial of Smoker's helpline.

    abstract：OBJECTIVE:Many women quit smoking during pregnancy resume in postpartum period and difficult to prevent. No studies had focused on their psychosocial response in Taiwan. We analyzed data from a trial of Taiwan Smoker's Helpline (TSH) to determine factors associated with smoking relapse after delivery. MATERIALS AND ME...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.tjog.2019.07.015

    authors： Lin CL,Lee TS,Hsu CC,Chen CY,Chao E,Shih SF,Hu HY

    更新日期：2019-09-01 00:00:00

  • Long-term survival outcomes of laparoscopic staging surgery in treating endometrial cancer: 20 years of follow-up.

    abstract：OBJECTIVE:To assess the long-term outcomes of laparoscopic staging surgery (LSS) in treating patients with endometrial carcinoma. MATERIALS AND METHODS:Patients with endometrial cancer who underwent LSS between June 1995 and June 2014 were prospectively registered. Perioperative data, complications, disease recurrence...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.04.035

    authors： Lee CL,Kusunoki S,Huang KG,Wu KY,Huang CY,Yen CF

    更新日期：2016-08-01 00:00:00

  • Prediction of hemorrhage in placenta previa.

    abstract：:Placenta previa poses a high risk for massive hemorrhage, from the antenatal period until after Cesarean section. This condition increases the risk of maternal and neonatal mortality and morbidity. In cases of placenta previa, the prenatal prediction of sudden bleeding during pregnancy and blood loss during Cesarean s...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tjog.2012.01.002

    authors： Hasegawa J,Nakamura M,Hamada S,Matsuoka R,Ichizuka K,Sekizawa A,Okai T

    更新日期：2012-03-01 00:00:00

  • Comparison of magnetic resonance-guided high-intensity focused ultrasound with uterine artery embolization for the treatment of uterine myoma: A systematic literature review and meta-analysis.

    abstract：OBJECTIVE:This study aimed to compare the outcomes of magnetic resonance-guided (MR-g) high-intensity focused ultrasound (HIFU) with uterine artery embolization (UAE) for the treatment of uterine myoma. MATERIALS AND METHODS:A systematic literature review and meta-analysis was conducted using database searches of Medl...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2020.07.012

    authors： Jeng CJ,Long CY,Chuang LT

    更新日期：2020-09-01 00:00:00

  • Monitoring bladder compliance using end filling detrusor pressure: Clinical results and related factors.

    abstract：OBJECTIVE:To assess the clinical significance of low compliance bladder (LCB) in women with lower urinary tract symptoms. MATERIALS AND METHODS:Medical records of 1490 women undergoing videourodynamic studies (VUSs) were reviewed. Comprehensive medical histories, physical examinations, bladder diaries, and results of ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2015.10.003

    authors： Liao JY,Lin YH,Liang CC,Hsieh WC,Lee SJ,Tseng LH

    更新日期：2015-12-01 00:00:00

  • The effect of mother-infant skin to skin contact on success and duration of first breastfeeding: A systematic review and meta-analysis.

    abstract：:Breast-feeding initiation within the first half hour after birth is one of the World Health Organization recommendations. However, in most hospitals, mother-infant contact and breast-feeding initiation are delayed due to routine mother and infant care. This study aimed to determine the effect of mother-infant skin to ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.tjog.2018.11.002

    authors： Karimi FZ,Sadeghi R,Maleki-Saghooni N,Khadivzadeh T

    更新日期：2019-01-01 00:00:00

  • Prenatal Group B Streptococcus test using real-time polymerase chain reaction.

    abstract：OBJECTIVE:The aim of this study was to evaluate the percentage of pregnant women with negative Group B Streptococcus (GBS) screening results by culture at 35 weeks' gestation, who subsequently had positive GBS test results after 39 weeks' gestation. MATERIALS AND METHODS:From 2006 to 2007, we recruited 150 pregnant wo...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S1028-4559(09)60269-2

    authors： Wei CF,She BC,Liang HS,Ling QD,Tsai CY,Yen CW,Wu HY,Tsai MS

    更新日期：2009-06-01 00:00:00

  • Prenatal diagnosis of congenital cystic adenomatoid malformations: evolution and outcome.

    abstract：OBJECTIVE:The aim of this study was to describe the natural history and outcomes of fetal congenital cystic adenomatoid malformation (CCAM) of the lung in three antenatally diagnosed cases. CASE REPORT:Three women whose fetuses had CCAM of the lung between 2004 and 2006 chose to continue their pregnancies. We followed...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(09)60304-1

    authors： Chen WS,Yeh GP,Tsai HD,Hsieh CT

    更新日期：2009-09-01 00:00:00

  • Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency.

    abstract：OBJECTIVE:Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. CASE REPORT:A 30-year-old woman, gravida 2 para 0, was referred to...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2019.09.021

    authors： Fujibe Y,Mariya T,Mizuuchi M,Ishioka S,Yoshida M,Saito T

    更新日期：2019-11-01 00:00:00

  • Carbetocin versus oxytocin for the prevention of postpartum hemorrhage: A meta-analysis of randomized controlled trials in cesarean deliveries.

    abstract：OBJECTIVE:Postpartum hemorrhage remains the leading cause of maternal mortality in developing countries and a significant proportion of these cases are attributable to uterine atony. In contrast to the advances made in the treatment of postpartum hemorrhage, there has been few novel prophylactic agents. This study was ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.tjog.2018.04.002

    authors： Voon HY,Suharjono HN,Shafie AA,Bujang MA

    更新日期：2018-06-01 00:00:00

  • Prevalence of nocturia in Taiwanese women aged 20-59 years.

    abstract：OBJECTIVE:To estimate the prevalence of nocturia in Taiwanese women aged 20-59 years. MATERIALS AND METHODS:A random sample of 4,549 women within the age range was selected by a multistage sampling design. Face-to-face visits with 3,537 women were completed by well-trained professional interviewers. Nocturia, accordin...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(08)60107-2

    authors： Hsieh CH,Chen HY,Hsu CS,Chang ST,Chiang CD

    更新日期：2007-03-01 00:00:00

  • Le Fort partial colpocleisis as an effective treatment option for advanced apical prolapse in elderly women.

    abstract：OBJECTIVE:The aim of this study was to evaluate the outcomes of women with advanced apical prolapse who were treated with the obliterative LeFort partial colpocleisis (LFC) procedure. MATERIALS AND METHODS:We reviewed the medical records of patients who underwent LFC for advanced apical prolapse. We collected data for...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2019.01.007

    authors： Park JY,Han SJ,Kim JH,Chun KC,Lee TS

    更新日期：2019-03-01 00:00:00

  • Changes in mitochondrial DNA copy number and extracellular matrix (ECM) proteins in the uterosacral ligaments of premenopausal women with pelvic organ prolapse.

    abstract：OBJECTIVE:The study aimed to explore the changes in mitochondrial DNA (mtDNA) copy number, collagen, and matrix metalloproteinase (MMPs) expression with pelvic organ prolapse (POP) in the uterosacral ligaments of premenopausal women. MATERIALS AND METHODS:A group of 56 premenopausal women, all younger than 52 years of...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.04.032

    authors： Sun MJ,Cheng YS,Sun R,Cheng WL,Liu CS

    更新日期：2016-02-01 00:00:00

  • Comparison of Quinn's Advantage fertilization medium and tissue culture medium 199 for in vitro maturation of oocytes.

    abstract：OBJECTIVE:The purpose of the study was to compare the Quinn's Advantage fertilization medium (Q1) and the tissue culture medium 199 (TCM199) for in vitro maturation (IVM) of oocytes and ammonium production during IVM. MATERIALS AND METHODS:The immature murine oocytes were randomly added into Q1 and TCM199. Ammonium co...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2013.12.001

    authors： Lin YH,Hwang JL,Huang LW,Seow KM,Hsieh BC,Tzeng CR

    更新日期：2014-03-01 00:00:00

  • Mosaic trisomy 7 at amniocentesis: prenatal diagnosis and molecular genetic analyses.

    abstract：OBJECTIVE:To present prenatal diagnosis and molecular genetic analyses of mosaic trisomy 7. MATERIALS, METHODS AND RESULTS:A 38-year-old primigravid woman underwent amniocentesis at 19 weeks of gestation because of her advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+7[26]/46, XY[16]. Repeated amnio...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(10)60070-8

    authors： Chen CP,Su YN,Chern SR,Hwu YM,Lin SP,Hsu CH,Tsai FJ,Wang TY,Wu PC,Lee CC,Chen YT,Chen LF,Wang W

    更新日期：2010-09-01 00:00:00

  • Successful ablation of acardiac twin with Histoacryl.

    abstract：OBJECTIVE:Acardiac twin occurs in 1:35,000 pregnancies. Several techniques have been described to treat this condition. Some techniques have been suggested as golden standard; however, new are still being tried. CASE REPORT:This is a case of a 32-year-old patient who had successful ablation of the acardiac twin with H...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.04.033

    authors： Ferianec V,Redecha M,Papcun P,Križko M Jr,Hollý I,Holomáň K

    更新日期：2016-02-01 00:00:00

  • Prenatal diagnosis of mosaic trisomy 2 associated with abnormal maternal serum screening, oligohydramnios, intrauterine growth restriction, ventricular septal defect, preaxial polydactyly, and facial dysmorphism.

    abstract：OBJECTIVE:To present prenatal diagnosis of mosaic trisomy 2. MATERIALS AND METHODS:A 29-year-old woman underwent amniocentesis at 17 weeks of gestation because of abnormal maternal serum screening, and the cytogenetic result was 47,XY,+2[8]/46,XY[22]. She underwent repeated amniocentesis at 19 weeks of gestation. Inte...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2013.06.004

    authors： Chen CP,Chen YY,Chern SR,Wu PS,Su JW,Chen YT,Lee CC,Chen LF,Wang W

    更新日期：2013-09-01 00:00:00

  • The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats.

    abstract：OBJECTIVE:Ischemia/reperfusion (I/R) injuries result in damage to endothelial and parenchymal cells. Oxytocin (OXY) stimulates uterine contraction during parturition and myoepithelial cells during suckling. OXY has been used as a protective antioxidant. Kisspeptin plays a key role in the central control of reproductive...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.12.018

    authors： Aslan M,Erkanli Senturk G,Akkaya H,Sahin S,Yılmaz B

    更新日期：2017-08-01 00:00:00