Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.

abstract：:We investigated the possible relationship between the susceptibility of cells to differentiation induced by phorbol 12-myristate 13-acetate (PMA) and the subcellular translocation of calcium- and phospholipid-dependent protein kinase (protein kinase C) activity from the cytosol to the membrane. These two events were a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Homma Y,Henning-Chubb CB,Huberman E

更新日期：1986-10-01 00:00:00

abstract：:Chlamydia trachomatis is a bacterial pathogen that infects the eyes and urogenital tract. Ocular infection by this organism is the leading cause of preventable blindness worldwide. The infection is also a leading cause of sexually transmitted disease in the United States. As obligate intracellular pathogens, chlamydia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lad SP,Li J,da Silva Correia J,Pan Q,Gadwal S,Ulevitch RJ,Li E

更新日期：2007-02-20 00:00:00

abstract：:Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila melanogaster, a complex including the five Male-Specific Lethal (MSL) proteins, "paints" the male X chromosome, med...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larsson J,Chen JD,Rasheva V,Rasmuson-Lestander A,Pirrotta V

更新日期：2001-05-22 00:00:00

abstract：:The elevation of Ca2+ levels in the cytoplasm inactivates inward-rectifying K+ channels that play a central role in regulating the apertures of stomatal pores in higher plants. However, the mechanism for the Ca(2+)-mediated inhibition of K(+)-channel function is unknown. Using patch-clamp techniques, we show that cycl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan S,Li W,Rusnak F,Assmann SM,Schreiber SL

更新日期：1993-03-15 00:00:00

abstract：:A patient with type II diabetes associated with hyperproinsulinemia has been shown to have a point mutation in one insulin gene allele, resulting in replacement of histidine with aspartic acid at position 10 of the B-chain. To investigate the basis of the proinsulin processing defect, we introduced an identical mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross DJ,Halban PA,Kahn CR,Weir GC,Villa-Komaroff L

更新日期：1989-06-01 00:00:00

abstract：:Language and analytic processing are currently thought to be represented in the left hemisphere, whereas spatial and holistic processing would involve primarily the right hemisphere in man. An experimental paradigm for engaging the nonlanguage hemisphere (generally the right) is described. This involves active touch e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desmedt JE

更新日期：1977-09-01 00:00:00

abstract：:Mutagenesis of protein-encoding sequences occurs ubiquitously; it enables evolution, accumulates during aging, and is associated with disease. Many biotechnological methods exploit random mutations to evolve novel proteins. To quantitate protein tolerance to random change, it is vital to understand the probability tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo HH,Choe J,Loeb LA

更新日期：2004-06-22 00:00:00

abstract：:Many ion channels exhibit a slow stochastic switching between distinct modes of gating activity. This feature of channel behavior has pronounced implications for the dynamics of ionic currents and the signaling pathways that they regulate. A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bicknell BA,Goodhill GJ

更新日期：2016-09-06 00:00:00

abstract：:Calcium/phospholipid-dependent protein kinase (protein kinase C, PKC) has been suggested to play a role in the sensitivity of gamma-aminobutyrate type A (GABAA) receptors to ethanol. We tested a line of null mutant mice that lacks the gamma isoform of PKC (PKC gamma) to determine the role of this brain-specific isoenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris RA,McQuilkin SJ,Paylor R,Abeliovich A,Tonegawa S,Wehner JM

更新日期：1995-04-25 00:00:00

abstract：:Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (hi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tietjen GT,Gong Z,Chen CH,Vargas E,Crooks JE,Cao KD,Heffern CT,Henderson JM,Meron M,Lin B,Roux B,Schlossman ML,Steck TL,Lee KY,Adams EJ

更新日期：2014-04-15 00:00:00

abstract：:A protein fraction from B. subtilis infected with phage SP01 (fraction LGG) stimulates the activity of RNA polymerase (EC 2.7.7.6; nucleosidetriphosphate:RNA nucleotidyltransferase) core from uninfected bacteria. Fraction LGG contains a protein (P-28, molecular weight 28,000) that is labeled after phage infection and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JJ,Petrusek RL,Geiduschek EP

更新日期：1975-06-01 00:00:00

abstract：:The discipline-wide effort to database the fossil record at the occurrence level has made it possible to estimate marine invertebrate extinction and origination rates with much greater accuracy. The new data show that two biotic mechanisms have hastened recoveries from mass extinctions and confined diversity to a rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alroy J

更新日期：2008-08-12 00:00:00

abstract：:Fanconi anemia (FA) is caused by defects in cellular responses to DNA crosslinking damage and replication stress. Given the constant occurrence of endogenous DNA damage and replication fork stress, it is unclear why complete deletion of FA genes does not have a major impact on cell proliferation and germ-line FA patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang R,Lenoir WF,Wang C,Su D,McLaughlin M,Hu Q,Shen X,Tian Y,Klages-Mundt N,Lynn E,Wood RD,Chen J,Hart T,Li L

更新日期：2020-12-29 00:00:00

abstract：:We propose a phylogeny for the evolution of tRNA that is based on the ubiquity and conservation of tRNA-like structures in the replication of contemporary genomes. This phylogeny is unique in suggesting that the function of tRNA in replication dates back to the very beginnings of life on earth, before the advent of te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maizels N,Weiner AM

更新日期：1994-07-19 00:00:00

abstract：:Ubiquitination, the crucial posttranslational modification that regulates the eukaryotic proteome, is carried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase). Although most E2s can work with any of the three mechanistically distinct classes of E3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dove KK,Kemp HA,Di Bona KR,Reiter KH,Milburn LJ,Camacho D,Fay DS,Miller DL,Klevit RE

更新日期：2017-08-08 00:00:00

abstract：:We present a comparative study of calorimetrically derived thermodynamic profiles for the binding of a series of drugs with selected DNA host duplexes. We use these data to demonstrate that comparisons between complete thermodynamic profiles (delta G zero, delta H zero, delta S zero, delta Cp) are required before drug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breslauer KJ,Remeta DP,Chou WY,Ferrante R,Curry J,Zaunczkowski D,Snyder JG,Marky LA

更新日期：1987-12-01 00:00:00

abstract：:Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)(-/-) mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs. By analyzing the orientation of developing hair follicles, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Badea T,Nathans J

更新日期：2006-12-26 00:00:00

abstract：:In the traditional Z scheme of photosynthesis the Emerson effects of red drop (decline in yield of photosynthesis in far-red light) and enhancement (of far-red yield by supplementary short-wavelength light) are taken to be evidence for the coupling in series of two photosystems that absorb unsymmetrically in the far-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner JW,Berry RS

更新日期：1987-06-01 00:00:00

abstract：:Apurinic/apyrimidinic (AP) sites are common DNA lesions that arise from spontaneous depurination or by base excision repair (BER) of modified bases. A biotin-containing aldehyde-reactive probe (ARP) [Kubo, K., Ide, H., Wallace, S. S. & Kow, Y. W. (1992) Biochemistry 31, 3703-3708] is used to measure AP sites in living...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atamna H,Cheung I,Ames BN

更新日期：2000-01-18 00:00:00

abstract：:Measurements of the effect of DNA on rates of bimolecular energy transfer between ions provide a direct indication of how cations cluster in regions near DNA and how anions are repelled from the same regions. Energy transfer from luminescent lanthanide ions (in the "rapid-diffusion" limit) probes collision frequencies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wensel TG,Meares CF,Vlachy V,Matthew JB

更新日期：1986-05-01 00:00:00

abstract：:We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino acids in culture (SILAC) coupled with nanospray tandem mass spectrometry, we identified CUB-domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Ong SE,Badu-Nkansah K,Schindler J,White FM,Hynes RO

更新日期：2011-01-25 00:00:00

abstract：:Gilles de la Tourette syndrome (TS) is characterized by tics, which are transiently worsened by stress, acute administration of dopaminergic drugs, and by subtle deficits in motor coordination and sensorimotor gating. It represents the most severe end of a spectrum of tic disorders that, in aggregate, affect ∼ 5% of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Kobets A,Du JC,Lennington J,Li L,Banasr M,Duman RS,Vaccarino FM,DiLeone RJ,Pittenger C

更新日期：2015-01-20 00:00:00

abstract：:Myosin V is an unconventional myosin proposed to be processive on actin filaments, analogous to kinesin on a microtubule [Mehta, A. D., et al. (1999) Nature (London) 400, 590-593]. To ascertain the unique properties of myosin V that permit processivity, we undertook a detailed kinetic analysis of the myosin V motor. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De La Cruz EM,Wells AL,Rosenfeld SS,Ostap EM,Sweeney HL

更新日期：1999-11-23 00:00:00

abstract：:Larval fishes suffer prodigious mortality rates, eliminating 99% of the brood within a few days after first feeding. Hjort (1914) famously attributed this "critical period" of low survival to the larvae's inability to obtain sufficient food [Hjort (1914) Rapp P-v Réun Cons Int Explor Mer 20:1-228]. However, the cause ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： China V,Holzman R

更新日期：2014-06-03 00:00:00

abstract：:A series of spontaneous suppressors to the temperature-sensitive phenotype of the single-stranded DNA-binding protein mutation ssb-1 were isolated. A genomic library of EcoRI fragments from one of these suppressor strains was prepared by using pBR325 as the cloning vector. A 10.0-kilobase class of inserts was identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruben SM,VanDenBrink-Webb SE,Rein DC,Meyer RR

更新日期：1988-06-01 00:00:00

abstract：:When animals move, respiration increases to adapt for increased energy demands; the underlying mechanisms are still not understood. We investigated the neural substrates underlying the respiratory changes in relation to movement in lampreys. We showed that respiration increases following stimulation of the mesencephal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariépy JF,Missaghi K,Chevallier S,Chartré S,Robert M,Auclair F,Lund JP,Dubuc R

更新日期：2012-01-10 00:00:00

abstract：:Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lonn E,Koskela E,Mappes T,Mokkonen M,Sims AM,Watts PC

更新日期：2017-04-04 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:Upon stimulation with anti-CD3, suppressor T-cell (Ts) hybridomas and homologous transfectants of T-cell receptor a (TCRalpha) cDNA in the T-cell hybridoma formed a 55-kDa TCRalpha chain derivative that bound both the monoclonal anti-TCRalpha chain and polyclonal antibodies against glycosylation inhibiting factor (GIF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii Y,Nakano T,Ishizaka K

更新日期：1996-07-09 00:00:00

abstract：:Regulation of gene expression through translational control is a fundamental mechanism implicated in many biological processes ranging from memory formation to innate immunity and whose dysregulation contributes to human diseases. Genome wide analyses of translational control strive to identify differential translatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larsson O,Sonenberg N,Nadon R

更新日期：2010-12-14 00:00:00