Abstract:
OBJECTIVE:To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults. METHODS:Participants were evaluated with the 40-item University of Pennsylvania Smell Identification Test (UPSIT). Follow-up occurred at 2-year intervals with information on death obtained from informant interviews and the National Death Index. RESULTS:During follow-up (mean = 4.1 years, standard deviation = 2.6), 349 of 1,169 (29.9%) participants died. Participants who died were more likely to be older (p < 0.001), be male (p < 0.001), have lower UPSIT scores (p < 0.001), and have a diagnosis of dementia (p < 0.001). In a Cox model, the association between lower UPSIT score and mortality (hazard ratio [HR] = 1.07 per point interval, 95% confidence interval [CI] = 1.05-1.08, p < 0.001) persisted after controlling for age, gender, education, ethnicity, language, modified Charlson medical comorbidity index, dementia, depression, alcohol abuse, head injury, smoking, body mass index, and vision and hearing impairment (HR = 1.05, 95% CI = 1.03-1.07, p < 0.001). Compared to the fourth quartile with the highest UPSIT scores, HRs for mortality for the first, second, and third quartiles of UPSIT scores were 3.81 (95% CI = 2.71-5.34), 1.75 (95% CI = 1.23-2.50), and 1.58 (95% CI = 1.09-2.30), respectively. Participant mortality rate was 45% in the lowest quartile of UPSIT scores (anosmia) and 18% in the highest quartile of UPSIT scores. INTERPRETATION:Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Devanand DP,Lee S,Manly J,Andrews H,Schupf N,Masurkar A,Stern Y,Mayeux R,Doty RLdoi
10.1002/ana.24447subject
Has Abstractpub_date
2015-09-01 00:00:00pages
401-11issue
3eissn
0364-5134issn
1531-8249journal_volume
78pub_type
杂志文章,随机对照试验abstract::We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during...
journal_title:Annals of neurology
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abstract::A persistent vegetative state (severe dementia) developed in a 30-year-old man following hypoglycemic coma. Despite the poor clinical outcome, sensory evoked response recovered between 6 and 34 months after the insult. The cerebral blood flow level at rest after 34 months was slightly above the normal range. This find...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410140414
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abstract::In this study, we preincubated the sera of 3 patients with neuropathies associated with elevated titers of IgM anti-GM1 antibodies, with increasing concentrations of intravenous Ig (IVIg) and assayed the inhibitory effect of this mixture on antibody binding to immobilized GM1 by an enzyme-linked immunosorbent assay. P...
journal_title:Annals of neurology
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doi:10.1002/ana.410390121
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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doi:10.1002/ana.24755
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410140415
更新日期:1983-10-01 00:00:00
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journal_title:Annals of neurology
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410200105
更新日期:1986-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410160402
更新日期:1984-10-01 00:00:00
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journal_title:Annals of neurology
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pub_type: 杂志文章,评审
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journal_title:Annals of neurology
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doi:10.1002/1531-8249(199908)46:2<161::aid-ana4>3.0.co
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1982-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Both animal and human data suggest that noradrenergic stimulation may enhance motor performance after brain damage. We conducted a placebo-controlled, double-blind and crossover design study to investigate the effects of noradrenergic stimulation on the cortical motor system in hemiparetic stroke patients. M...
journal_title:Annals of neurology
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1979-04-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.1258
更新日期:2001-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.21827
更新日期:2010-01-01 00:00:00