Intravenous gamma-globulin inhibits binding of anti-GM1 to its target antigen.


:In this study, we preincubated the sera of 3 patients with neuropathies associated with elevated titers of IgM anti-GM1 antibodies, with increasing concentrations of intravenous Ig (IVIg) and assayed the inhibitory effect of this mixture on antibody binding to immobilized GM1 by an enzyme-linked immunosorbent assay. Pharmacologic concentrations of IVIg, ranging from 0.1 microgram/ml to 100 mg/ml, inhibited anti-GM1 binding to its target antigen from 26 +/- 3 to 71 +/- 7%, respectively, in a dose-dependent manner. A similar inhibition of binding was also observed with IVIg F(ab')2 fragments. These findings provide a possible mechanism for the clinical efficacy of IVIg in motor neuropathies.


Ann Neurol


Annals of neurology


Malik U,Oleksowicz L,Latov N,Cardo LJ




Has Abstract


1996-01-01 00:00:00












  • Cerebrovascular abnormalities in pediatric stroke: assessment using parenchymal and angiographic magnetic resonance imaging.

    abstract::Three-dimensional (volume) magnetic resonance angiography is a noninvasive technique that images the intracranial and cervical arterial vasculature without contrast agents. Twenty-four children with strokes had combined parenchymal magnetic resonance imaging and magnetic resonance angiography 1 day to 4 years after ac...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Wiznitzer M,Masaryk TJ

    更新日期:1991-06-01 00:00:00

  • Prion protein heterogeneity in sporadic but not variant Creutzfeldt-Jakob disease: UK cases 1991-2002.

    abstract::Human prion diseases can occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the case for variant Creutzfeldt-Jakob disease. These disorders are characterized by the accumulation of a protease-resistant form of the host-encoded prion protein termed PrP(Sc) in the brains of af...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Head MW,Bunn TJ,Bishop MT,McLoughlin V,Lowrie S,McKimmie CS,Williams MC,McCardle L,MacKenzie J,Knight R,Will RG,Ironside JW

    更新日期:2004-06-01 00:00:00

  • Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis.

    abstract:OBJECTIVE:Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs disrupt the blood-brain barrier (BBB), but the mechanisms are unknown. METHODS:A total of six CSDs were evoked over 1 hour by topical application of 30...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sadeghian H,Lacoste B,Qin T,Toussay X,Rosa R,Oka F,Chung DY,Takizawa T,Gu C,Ayata C

    更新日期:2018-09-01 00:00:00

  • Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.

    abstract::Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Sriram S,Steiner I

    更新日期:2005-12-01 00:00:00

  • Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis.

    abstract::Membrane cofactor protein (CD46) is a member of a family of glycoproteins that are regulators of complement and prevent activation of complement on autologous cells. Recently, CD46 has been identified as the cellular receptor for human herpesvirus Type 6 (HHV-6). Elevated levels of soluble CD46 have been described in ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Soldan SS,Fogdell-Hahn A,Brennan MB,Mittleman BB,Ballerini C,Massacesi L,Seya T,McFarland HF,Jacobson S

    更新日期:2001-10-01 00:00:00

  • Weakness in malignancy: evidence for a remote effect of tumor on distal axons.

    abstract::Malignant tumors are known to have a "remote" or nonmetastatic effect on the central and peripheral nervous systems. Eight patients were seen with proximal muscle weakness in association with bronchogenic carcinoma (5), carcinoma of breast (2), and leukemia (1). Electromyography demonstrated small polyphasic motor uni...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Barron SA,Heffner RR Jr

    更新日期:1978-09-01 00:00:00

  • Polysomnographic diagnosis of sleepwalking: effects of sleep deprivation.

    abstract:OBJECTIVE:Somnambulism affects up to 4% of adults and constitutes one of the leading causes of sleep-related violence and self-injury. Diagnosing somnambulism with objective instruments is often difficult because episodes rarely occur in the laboratory. Because sleep deprivation can precipitate sleepwalking, we aimed t...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Zadra A,Pilon M,Montplaisir J

    更新日期:2008-04-01 00:00:00

  • Evidence of hydrogen sulfide involvement in amyotrophic lateral sclerosis.

    abstract:OBJECTIVE:Amyotrophic lateral sclerosis (ALS) is a motor neuron disease whose pathophysiological deficits, causing impairment in motor function, are largely unknown. Here we propose that hydrogen sulfide (H2 S), as a glial-released inflammatory factor, contributes to ALS-mediated motor neuron death. METHODS:H2 S conce...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Davoli A,Greco V,Spalloni A,Guatteo E,Neri C,Rizzo GR,Cordella A,Romigi A,Cortese C,Bernardini S,Sarchielli P,Cardaioli G,Calabresi P,Mercuri NB,Urbani A,Longone P

    更新日期:2015-04-01 00:00:00

  • RYR1 mutations are a common cause of congenital myopathies with central nuclei.

    abstract:OBJECTIVE:Centronuclear myopathy (CNM) is a rare congenital myopathy characterized by prominence of central nuclei on muscle biopsy. CNM has been associated with mutations in MTM1, DNM2, and BIN1 but many cases remain genetically unresolved. RYR1 encodes the principal sarcoplasmic reticulum calcium release channel and ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Wilmshurst JM,Lillis S,Zhou H,Pillay K,Henderson H,Kress W,Müller CR,Ndondo A,Cloke V,Cullup T,Bertini E,Boennemann C,Straub V,Quinlivan R,Dowling JJ,Al-Sarraj S,Treves S,Abbs S,Manzur AY,Sewry CA,Muntoni F,Jung

    更新日期:2010-11-01 00:00:00

  • Depletion of corticotrophin-releasing factor neurons in the pontine micturition area in multiple system atrophy.

    abstract::We sought to determine whether the putative pontine micturition center in the human dorsal pons contains corticotrophin-releasing factor (CRF) neurons, and whether these neurons are depleted in patients with multiple system atrophy and bladder dysfunction. Brains were obtained at autopsy from 4 control subjects and 4 ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Benarroch EE,Schmeichel AM

    更新日期:2001-11-01 00:00:00

  • Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.

    abstract:OBJECTIVE:This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether brain weight (BW) and Alzheimer lesions (neurofibrillary tangles [NFTs] or neuritic plaques [NPs]) mediate the association. METHODS:Subjects were 436 well-character...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Launer LJ,Hughes TM,White LR

    更新日期:2011-11-01 00:00:00

  • Neuropeptides: a role as endogenous mediators or modulators of epileptic phenomena.

    abstract::As more small peptidergic components of the central nervous system are isolated, their role in disease states is being investigated. Several of these neuropeptides, especially the opioidlike peptides, adrenocorticotropic hormone, and some hypothalamic releasing factors, have been found to alter neuronal excitability. ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bajorek JG,Lee RJ,Lomax P

    更新日期:1984-01-01 00:00:00

  • Involvement of lysosomes in the pathogenesis of CAG repeat diseases.

    abstract::In CAG repeat diseases, affected neurons possess many cytoplasmic granules immunopositive for expanded polyglutamine stretches. Electron microscopic immunohistochemistry showed that the granules corresponded to lysosomes of primitive type. The results suggest that, in addition to the ubiquitin/proteasome pathway, muta...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Yamada M,Tsuji S,Takahashi H

    更新日期:2002-10-01 00:00:00

  • Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease.

    abstract::Few studies evaluate neuropathological correlates of behavioral changes in Alzheimer disease (AD). We identified 31 autopsy patients with a diagnosis of definite AD. Behavioral changes were assessed with the Neuropsychiatric Inventory. Brain sections were collected from bilateral orbitofrontal and left anterior cingul...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Tekin S,Mega MS,Masterman DM,Chow T,Garakian J,Vinters HV,Cummings JL

    更新日期:2001-03-01 00:00:00

  • Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex.

    abstract::Recent studies have indicated a normal gene dose for the amyloid precursor protein (APP) in Alzheimer's disease (AD). These findings leave open the possibility that elevated levels of messenger RNA (mRNA) for this protein may contribute to the pathogenesis of AD. Using Northern analysis, we compared the levels of mRNA...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Clark AW,Krekoski CA,Parhad IM,Liston D,Julien JP,Hoar DI

    更新日期:1989-04-01 00:00:00

  • Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis.

    abstract:OBJECTIVE:Recent studies carried out on amyotrophic lateral sclerosis patients suggest that the disease might initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed to test the corticofugal hypothesis of amyotrophic lateral sclerosis experimentally. METHODS:Sod1G8...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Burg T,Bichara C,Scekic-Zahirovic J,Fischer M,Stuart-Lopez G,Brunet A,Lefebvre F,Cordero-Erausquin M,Rouaux C

    更新日期:2020-10-01 00:00:00

  • Age-dependent changes in the ability to encode a novel elementary motor memory.

    abstract::In healthy individuals, motor training elicits cortical plasticity that encodes the kinematic details of the practiced movements and is thought to underlie recovery of function after stroke. The influence of age on this form of plasticity is incompletely understood. We studied 55 healthy subjects and identified a subs...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sawaki L,Yaseen Z,Kopylev L,Cohen LG

    更新日期:2003-04-01 00:00:00

  • Physiology of freezing of gait.

    abstract::Freezing of gait (FOG) is a common and debilitating, but largely mysterious, symptom of Parkinson disease. In this review, we will discuss the cerebral substrate of FOG focusing on brain physiology and animal models. Walking is a combination of automatic movement processes, afferent information processing, and intenti...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Snijders AH,Takakusaki K,Debu B,Lozano AM,Krishna V,Fasano A,Aziz TZ,Papa SM,Factor SA,Hallett M

    更新日期:2016-11-01 00:00:00

  • Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction.

    abstract::Disorders of neuronal migration in cerebral cortex are associated with neurological impairments, including mental retardation and epilepsy. Their causes and pathophysiology remain largely unknown, however. In patients with Zellweger disease, a lethal panperoxisomal disorder, and in mice lacking the Pxr1 import recepto...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Gressens P,Baes M,Leroux P,Lombet A,Van Veldhoven P,Janssen A,Vamecq J,Marret S,Evrard P

    更新日期:2000-09-01 00:00:00

  • Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis.

    abstract::An increasing spectrum of diseases has been shown to be associated with the human T-cell lymphotropic virus type I (HTLV-I), most notably a chronic, progressive myelopathy termed HTLV-I--associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia. HTLV-II is a close relative of HTLV-I and is structura...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Jacobson S,Lehky T,Nishimura M,Robinson S,McFarlin DE,Dhib-Jalbut S

    更新日期:1993-04-01 00:00:00

  • Cerebrospinal fluid vasopressin and increased intracranial pressure.

    abstract::Cerebrospinal fluid and plasma vasopressin were measured in patients with cerebral disorders associated with varying levels of elevated intracranial pressure. The mean cerebrospinal fluid vasopressin concentration was significantly increased in patients with pseudotumor cerebri (2.0 +/- 0.2 [SEM] pg/ml), intracranial ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sørensen PS,Gjerris F,Hammer M

    更新日期:1984-05-01 00:00:00

  • Phenobarbital modifies seizure-related brain injury in the developing brain.

    abstract::To investigate the potential role of drug therapy in preventing or exacerbating seizure-related brain injury in the prepubescent brain, we administered kainic acid to rats at postnatal day 35. Therapy with daily phenobarbital was started directly before or 1 day after kainic acid was administered, and was continued th...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Mikati MA,Holmes GL,Chronopoulos A,Hyde P,Thurber S,Gatt A,Liu Z,Werner S,Stafstrom CE

    更新日期:1994-09-01 00:00:00

  • Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.

    abstract:OBJECTIVE:Prolonged human immunodeficiency virus-1 (HIV-1) infection leads to neurological debilitation, including motor dysfunction and frank dementia. Although pharmacological control of HIV infection is now possible, HIV-associated neurocognitive disorders (HAND) remain intractable. Here, we report that chronic trea...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kang YJ,Digicaylioglu M,Russo R,Kaul M,Achim CL,Fletcher L,Masliah E,Lipton SA

    更新日期:2010-09-01 00:00:00

  • Hypothalamic mass and gigantism in neurofibromatosis: treatment with bromocriptine.

    abstract::A child with neurofibromatosis exhibited gigantism and acromegaly in association with a hypothalamic mass lesion. Bromocriptine, 5 mg daily, reduced somatic growth rate and restored biochemical homeostasis but had no effect on tumor growth. Radiation therapy arrested tumor enlargement and stabilized deteriorating visu...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Duchowny MS,Katz R,Bejar RL

    更新日期:1984-03-01 00:00:00

  • Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.

    abstract::In a prospective phase I/II clinical study, we treated eight patients suffering from recurrent glioblastoma multiform with stereotactically guided intratumoral convection-enhanced delivery of an HSV-1-tk gene-bearing liposomal vector and systemic ganciclovir. Noninvasive identification of target tissue together with a...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章


    authors: Voges J,Reszka R,Gossmann A,Dittmar C,Richter R,Garlip G,Kracht L,Coenen HH,Sturm V,Wienhard K,Heiss WD,Jacobs AH

    更新日期:2003-10-01 00:00:00

  • Benzodiazepine receptors in focal epilepsy with cortical dysgenesis: an 11C-flumazenil PET study.

    abstract::Previous imaging studies using 11C-flumazenil in patients with mesial temporal lobe epilepsy and neocortical partial seizure disorders have found focal decreases in gamma-aminobutyric acid type A/benzodiazepine receptor binding. These studies used subjective visual assessment and a region of interest approach to quant...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Richardson MP,Koepp MJ,Brooks DJ,Fish DR,Duncan JS

    更新日期:1996-08-01 00:00:00

  • Multiple sclerosis and viruses.

    abstract::Discussing the problem of multiple sclerosis and viruses should not be limited to reviewing the epidemiological evidence in favor, or against, a particular candidate, such as Epstein-Barr virus or human herpes virus 6. In this text, I discuss the difficulty of going from association to causation in human epidemiology;...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Brahic M

    更新日期:2010-07-01 00:00:00

  • An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease.

    abstract::We report an immunohistochemical study of the mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) in the substantia nigra in Parkinson's disease. The KGDHC, the three enzyme complex catalyzing the oxidation of alpha-ketoglutarate to succinate through succinic semialdehyde, is the rate-regulating enzyme of ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Mizuno Y,Matuda S,Yoshino H,Mori H,Hattori N,Ikebe S

    更新日期:1994-02-01 00:00:00

  • Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.

    abstract::Layer II of the entorhinal cortex contains the cells of origin for the perforant path, plays a critical role in memory processing, and consistently degenerates in end-stage Alzheimer's disease. The extent to which neuron loss in layer II of entorhinal cortex is related to mild cognitive impairment without dementia has...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kordower JH,Chu Y,Stebbins GT,DeKosky ST,Cochran EJ,Bennett D,Mufson EJ

    更新日期:2001-02-01 00:00:00

  • Greater effect of stroke thrombolysis in the presence of arterial obstruction.

    abstract:OBJECTIVE:Recanalization of arterial obstruction is associated with improved clinical outcomes. There are no controlled data demonstrating whether arterial obstruction status predicts the treatment effect of intravenous (IV) tissue plasminogen activator (tPA). We aimed to determine if the presence of arterial obstructi...

    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验


    authors: De Silva DA,Churilov L,Olivot JM,Christensen S,Lansberg MG,Mlynash M,Campbell BC,Desmond P,Straka M,Bammer R,Albers GW,Davis SM,Donnan GA,EPITHET-DEFUSE Investigators.

    更新日期:2011-10-01 00:00:00