Intravenous gamma-globulin inhibits binding of anti-GM1 to its target antigen.

Abstract:

:In this study, we preincubated the sera of 3 patients with neuropathies associated with elevated titers of IgM anti-GM1 antibodies, with increasing concentrations of intravenous Ig (IVIg) and assayed the inhibitory effect of this mixture on antibody binding to immobilized GM1 by an enzyme-linked immunosorbent assay. Pharmacologic concentrations of IVIg, ranging from 0.1 microgram/ml to 100 mg/ml, inhibited anti-GM1 binding to its target antigen from 26 +/- 3 to 71 +/- 7%, respectively, in a dose-dependent manner. A similar inhibition of binding was also observed with IVIg F(ab')2 fragments. These findings provide a possible mechanism for the clinical efficacy of IVIg in motor neuropathies.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Malik U,Oleksowicz L,Latov N,Cardo LJ

doi

10.1002/ana.410390121

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

136-9

issue

1

eissn

0364-5134

issn

1531-8249

journal_volume

39

pub_type

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